Reactome | monoSUMO1-K462-HDAC2 [nucleoplasm]

monoSUMO1-K462-HDAC2 [nucleoplasm]

Stable Identifier

R-HSA-4615958

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone deacetylase 2, HDAC2_HUMAN

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External Reference Information

External Reference

UniProt:Q92769 HDAC2

Gene Names

HDAC2

Chain

chain:1-488

Reference Genes

BioGPS Gene:3066 HDAC2

COSMIC (genes):HDAC2 HDAC2

CTD Gene:3066 HDAC2

dbSNP Gene:3066 HDAC2

ENSEMBL:ENSG00000196591 HDAC2

ENSEMBL:ENSG00000196591.12 HDAC2

HGNC:4853 HDAC2

KEGG Gene (Homo sapiens):3066 HDAC2

Monarch:3066 HDAC2

NCBI Gene:3066 HDAC2

OMIM:605164 HDAC2

UCSC:Q92769 HDAC2

Reference Transcript

Other Identifiers

11727379_at

11754781_a_at

201833_PM_at

201833_at

242141_PM_at

242141_at

2970534

2970535

2970536

2970537

2970538

2970539

2970540

2970541

2970542

2970543

2970544

2970545

2970546

2970548

2970549

2970550

2970551

2970552

2970553

2970556

2970557

2970562

2970566

2970567

2970571

2970573

2970575

2970577

2970578

2970579

2970580

2970581

2970582

2970583

3066

34368_at

8129045

A_23_P122304

A_33_P3309924

GE81034

GE860085

GO:0000118

GO:0000122

GO:0000228

GO:0000781

GO:0000785

GO:0001975

GO:0003012

GO:0003300

GO:0003677

GO:0003682

GO:0003723

GO:0003824

GO:0004407

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0008284

GO:0009410

GO:0009913

GO:0010718

GO:0010977

GO:0012501

GO:0016358

GO:0016575

GO:0016580

GO:0016581

GO:0016787

GO:0019213

GO:0019899

GO:0022414

GO:0023052

GO:0030154

GO:0030336

GO:0030512

GO:0031000

GO:0031072

GO:0031492

GO:0032496

GO:0032732

GO:0032760

GO:0032922

GO:0032967

GO:0032991

GO:0033558

GO:0034605

GO:0035094

GO:0035098

GO:0036211

GO:0042220

GO:0042475

GO:0042531

GO:0042659

GO:0042733

GO:0042826

GO:0043066

GO:0043226

GO:0043392

GO:0043433

GO:0043565

GO:0045347

GO:0045862

GO:0045892

GO:0045893

GO:0045944

GO:0048149

GO:0048511

GO:0048714

GO:0048856

GO:0048870

GO:0051059

GO:0055093

GO:0060789

GO:0061000

GO:0061029

GO:0061198

GO:0061629

GO:0070301

GO:0070828

GO:0070932

GO:0071300

GO:0071560

GO:0140096

GO:0160008

GO:0160009

GO:0160010

GO:1902437

GO:1902455

GO:1902459

GO:1903351

GO:1990841

GO:2000273

GO:2000736

GO:2000757

HMNXSV003001184

Hs.232662.0.A1_3p_at

Hs.232662.0.A1_3p_x_at

ILMN_1767747

PH_hs_0000406

TC06002035.hg

TC06003812.hg

U31814_at

g4557640_3p_at

Participates

as an output of

SUMOylation of HDAC2 with SUMO1 (Homo sapiens)

Other forms of this molecule

HDAC2 [nucleoplasm]

Inferred To

monoSUMO1-K462-HDAC2 [nucleoplasm] (Bos taurus)

monoSUMO1-K462-HDAC2 [nucleoplasm] (Caenorhabditis elegans)

monoSUMO1-K462-HDAC2 [nucleoplasm] (Danio rerio)

monoSUMO1-K462-HDAC2 [nucleoplasm] (Dictyostelium discoideum)

monoSUMO1-K462-HDAC2 [nucleoplasm] (Gallus gallus)

monoSUMO1-K462-HDAC2 [nucleoplasm] (Xenopus tropicalis)

hda-1 [nucleoplasm] (Caenorhabditis elegans)

clr6 [nucleoplasm] (Schizosaccharomyces pombe)

Hdac2 [nucleoplasm] (Mus musculus)

Hdac2 [nucleoplasm] (Rattus norvegicus)

Homologues of monoSUMO1-K462-HDAC2 [nucleoplasm] (Caenorhabditis elegans)

RPD3 [nucleoplasm] (Saccharomyces cerevisiae)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 462

Coordinate

462

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_001518.3, XP_016866288.1, XP_011534090.1

ZINC - World Drugs

HDAC2_HUMAN

Guide to Pharmacology - Targets

2616

OpenTargets

ENSG00000196591

ZINC - FDA approved

HDAC2_HUMAN

ZINC - Substances

HDAC2_HUMAN

ZINC - Biogenic

HDAC2_HUMAN

ZINC target

Q92769

PRO

Q92769

PDB

7LTG, 5IWG, 6WHO, 7ZZO, 6XEC, 7KBG, 6WBZ, 7JS8, 4LY1, 7ZZW, 6WBW, 6XEB, 6WHN, 7KBH, 7LTL, 7LTK, 8A0B, 4LXZ, 3MAX, 7MOS, 5IX0, 6G3O, 7ZZP, 7MOT, 6WHQ, 7MOX, 7ZZS, 6WHZ, 6WI3, 7MOY, 6XDM, 7ZZR, 7ZZU, 7MOZ, 7ZZT

ZINC - Investigational

HDAC2_HUMAN

ZINC - Metabolites

HDAC2_HUMAN

HPA

ENSG00000196591-HDAC2

GeneCards

Q92769

Ensembl

ENSP00000430432, ENSP00000357621, ENST00000519108, ENST00000519065, ENST00000368632, ENSG00000196591, ENSP00000430008

Pharos - Targets

Q92769

ZINC - Predictions - Purchasable

HDAC2_HUMAN

Orphanet

24589

HMDB Protein

HMDBP09107

Interactors (60)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.937	16
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.848	6
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.839	6
UniProt:O94776 MTA2	1	MTA2 [nucleoplasm] (R-HSA-4657009)	0.837	8
UniProt:Q9BTC8 MTA3	1	MTA3 [nucleoplasm] (R-HSA-4657013)	0.788	6
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.788	8
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.758	5
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.725	4
UniProt:Q9NP66 HM20A			0.725	4
UniProt:Q9UKL0 RCOR1	1	RCOR1 [nucleoplasm] (R-HSA-996766)	0.725	4
UniProt:Q6PJG2 MDEAS			0.725	4
UniProt:Q8WXI9 GATAD2B	1	GATAD2B [nucleoplasm] (R-HSA-3702079)	0.725	4
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.725	5
UniProt:Q9UBB5 MBD2	1	MBD2 [nucleoplasm] (R-HSA-427367)	0.725	4
UniProt:Q9HCU9 BRMS1	1	BRMS1 [nucleoplasm] (R-HSA-4650034)	0.723	4
UniProt:O75182 SIN3B	1	SIN3B [nucleoplasm] (R-HSA-3006450)	0.643	3
UniProt:Q86YP4 GATAD2A	1	GATAD2A [nucleoplasm] (R-HSA-3702077)	0.643	3
UniProt:Q8N108 MIER1			0.643	3
UniProt:Q9UBW7 ZMYM2	6	ZMYM2(1-913)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839016) ZMYM2(1-913)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604544) ZMYM2(1-1059)-p-4Y-FLT3(594-993) fusion [cytosol] (R-HSA-9703309) ZMYM2(1-1057)-p-5Y-FLT3(586-993) fusion [cytosol] (R-HSA-9703319) ZMYM2(1-1059)-FLT3(594-993) fusion [cytosol] (R-HSA-9703310) ZMYM2(1-1057)-FLT3(586-993) fusion [cytosol] (R-HSA-9703311)	0.643	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.643	3
UniProt:Q14687 GSE1			0.643	3
UniProt:O14519 CDKA1			0.643	3
UniProt:Q9P2K3 RCOR3			0.643	3
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.643	4
UniProt:Q9Y232 CDYL			0.643	4
UniProt:Q9C0K0 BC11B			0.602	3
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.597	7
UniProt:P0DTD1-PRO_0000449623 REP			0.589	2
UniProt:Q9HD15 SRA1			0.589	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.564	2
UniProt:Q92618 ZN516			0.558	6
UniProt:Q2HR82 KBZIP			0.537	7
UniProt:Q8N5A5 ZGPAT			0.532	3
UniProt:Q96BD5 PHF21A	1	PHF21A [nucleoplasm] (R-HSA-996754)	0.527	2
UniProt:Q92766 RREB1			0.527	2
UniProt:Q8N344 MIER2			0.527	2
UniProt:Q8IZ40 RCOR2			0.527	2
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.527	2
UniProt:Q9H0E3 SAP130	1	SAP130 [nucleoplasm] (R-HSA-3006732)	0.527	2
UniProt:Q9H147 TDIF1			0.527	3
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.527	2
UniProt:O75446 SAP30	1	SAP30 [nucleoplasm] (R-HSA-351693)	0.527	2
UniProt:Q9H7L9 SUDS3	2	K63polyUb-SUDS3 [nucleoplasm] (R-HSA-6782790) SUDS3 [nucleoplasm] (R-HSA-351696)	0.527	2
UniProt:Q9P0W2 HMG20B	1	HMG20B [nucleoplasm] (R-HSA-996745)	0.527	2
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.527	2
UniProt:Q13363 CTBP1	3	monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) CTBP1 [nucleoplasm] (R-HSA-212372)	0.527	8
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.525	2
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.524	3
UniProt:Q9UIS9 MBD1	2	monoSUMO1-K499,K538-MBD1 [nucleoplasm] (R-HSA-4090331) MBD1 [nucleoplasm] (R-HSA-417134)	0.524	2
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.524	2
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.508	2
UniProt:Q17R98 ZN827			0.499	2
UniProt:P51610 HCFC1	2	HCFC1 [nucleoplasm] (R-HSA-1592209) K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821)	0.499	2
UniProt:P48382 RFX5			0.499	4
UniProt:O60315 ZEB2	1	ZEB2 [nucleoplasm] (R-HSA-3108222)	0.462	4
UniProt:Q9BSJ6 PIMRE			0.462	2
UniProt:A2A935	1	Prdm16 [cytosol] (R-MMU-5634812)	0.462	2
UniProt:P17542 TAL1	1	TAL1 [nucleoplasm] (R-HSA-8956511)	0.462	3
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.462	4

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