Reactome | IMPDH2 [cytosol]

IMPDH2 [cytosol]

Stable Identifier

R-HSA-57350

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IMP (inosine monophosphate) dehydrogenase 2, Inosine-5'-monophosphate dehydrogenase 2 (EC 1.1.1.205) (IMP dehydrogenase 2) (IMPDH-II) (IMPD 2), Inosine-5'-monophosphate dehydrogenase 2 , IMP dehydrogenase 2, IMPDH-II, IMPD 2

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        IMPDH tetramers binds IMPDH inhibitors (Homo sapiens)
        
        IMPDH tetramers [cytosol] (Homo sapiens)
        
        IMPDH2 tetramer [cytosol] (Homo sapiens)
        
        IMPDH2 [cytosol] (Homo sapiens)
        
        IMPDH tetramers:IMPDH inhibitors [cytosol] (Homo sapiens)
        
        IMPDH tetramers [cytosol] (Homo sapiens)
        
        IMPDH2 tetramer [cytosol] (Homo sapiens)
        
        IMPDH2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P12268 IMPDH2

Gene Names

IMPDH2, IMPD2

Chain

initiator methionine:1, chain:2-514

Reference Genes

BioGPS Gene:3615 IMPDH2

COSMIC (genes):IMPDH2 IMPDH2

CTD Gene:3615 IMPDH2

dbSNP Gene:3615 IMPDH2

ENSEMBL:ENSG00000178035 IMPDH2

ENSEMBL:ENSG00000178035.13 IMPDH2

HGNC:6053 IMPDH2

KEGG Gene (Homo sapiens):3615 IMPDH2

Monarch:3615 IMPDH2

NCBI Gene:3615 IMPDH2

OMIM:146691 IMPDH2

UCSC:P12268 IMPDH2

Reference Transcript

RefSeq:NM_000884.2 IMPDH2

Other Identifiers

11740923_a_at

11740924_x_at

11744423_a_at

11752370_x_at

11757427_x_at

16953813

201892_PM_s_at

201892_s_at

2673875

2673877

2673879

2673881

2673882

2673885

2673886

2673887

2673889

2673890

2673893

2673895

2673898

2673900

2673901

3615

36624_at

8087254

A_33_P3214298

GE57726

GO:0000166

GO:0002376

GO:0003677

GO:0003723

GO:0003824

GO:0003938

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005777

GO:0005778

GO:0005829

GO:0006164

GO:0006177

GO:0006183

GO:0007623

GO:0016020

GO:0016491

GO:0031410

GO:0034774

GO:0043226

GO:0046651

GO:0046872

GO:0055086

GO:0070062

GO:0071353

GO:0097294

GO:1901135

GO:1904813

HMNXSV003008658

L33842_rna1_at

PH_hs_0004326

PH_hs_0035456

TC03001397.hg

g4504688_3p_s_at

Participates

as a component of

IMPDH2 tetramer [cytosol] (Homo sapiens)

Other forms of this molecule

IMPDH2 [secretory granule lumen]

IMPDH2 [extracellular region]

IMPDH2 [ficolin-1-rich granule lumen]

Inferred To

Homologues of IMPDH2 [cytosol] (Saccharomyces cerevisiae)

IMPDH1 [cytosol] (Caenorhabditis elegans)

IMPDH1 [cytosol] (Dictyostelium discoideum)

IMPDH1 [cytosol] (Drosophila melanogaster)

IMPDH1 [cytosol] (Plasmodium falciparum)

IMPDH1 [cytosol] (Saccharomyces cerevisiae)

IMPDH1 [cytosol] (Schizosaccharomyces pombe)

IMPDH2 [cytosol] (Bos taurus)

IMPDH2 [cytosol] (Canis familiaris)

IMPDH2 [cytosol] (Danio rerio)

IMPDH2 [cytosol] (Gallus gallus)

IMPDH2 [cytosol] (Mus musculus)

IMPDH2 [cytosol] (Rattus norvegicus)

IMPDH2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_000875.2

ZINC - World Drugs

IMDH2_HUMAN

Guide to Pharmacology - Targets

2625

OpenTargets

ENSG00000178035

ZINC - FDA approved

IMDH2_HUMAN

ZINC - Substances

IMDH2_HUMAN

ZINC - Biogenic

IMDH2_HUMAN

ZINC target

P12268

PRO

P12268

PDB

1B3O, 6U8E, 6U8S, 1NFB, 6UDQ, 6UAJ, 1NF7, 6I0O, 6U8R, 6UA5, 6UDP, 6U8N, 6UA4, 6I0M, 6UA2, 6U9O, 6UC2, 6UDO

IntEnz

1.1.1.205

HPA

ENSG00000178035-IMPDH2

GeneCards

P12268

Ensembl

ENSG00000178035, ENST00000326739, ENSP00000321584

Pharos - Targets

P12268

ZINC - Predictions - Purchasable

IMDH2_HUMAN

HMDB Protein

HMDBP00881

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:Q96GX9 APIP	1	APIP [cytosol] (R-HSA-1237171)	0.556	3
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.556	3
UniProt:Q8WWZ1 IL1F10	3	IL1F10(?-152) [extracellular region] (R-HSA-9007903) IL1F10(1-?) [extracellular region] (R-HSA-9007899) IL1F10 [extracellular region] (R-HSA-8863045)	0.556	3
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:P0DTC4 E	9	N-glycan E [endoplasmic reticulum lumen] (R-COV-9694754) nascent E [endoplasmic reticulum lumen] (R-COV-9694312) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694305) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694423) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9694465) Ub-3xPalmC-E [Golgi membrane] (R-COV-9694687) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698420) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698422) Ub-3xPalmC-E [virion membrane] (R-COV-9698416)	0.482	2

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