Reactome | PPP6R1 [cytosol]

PPP6R1 [cytosol]

Stable Identifier

R-HSA-5685721

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        PP6 dephosphorylates SEC24 (Homo sapiens)
        
        PP6 [cytosol] (Homo sapiens)
        
        PPP6R1,3 [cytosol] (Homo sapiens)
        
        PPP6R1 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - PP6 dephosphorylates SEC24 (Homo sapiens)
        
        PP6 [cytosol] (Homo sapiens)
        
        PPP6R1,3 [cytosol] (Homo sapiens)
        
        PPP6R1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UPN7 PPP6R1

Gene Names

PPP6R1, KIAA1115, PP6R1, SAPS1

Chain

chain:1-881

Reference Genes

BioGPS Gene:22870 PPP6R1

COSMIC (genes):PPP6R1 PPP6R1

CTD Gene:22870 PPP6R1

dbSNP Gene:22870 PPP6R1

ENSEMBL:ENSG00000105063 PPP6R1

ENSEMBL_homo_sapiens_GENE:ENSG00000105063.19 PPP6R1

HGNC:29195 PPP6R1

KEGG Gene (Homo sapiens):22870 PPP6R1

Monarch:22870 PPP6R1

NCBI Gene:22870 PPP6R1

OMIM:610875 PPP6R1

UCSC:Q9UPN7 PPP6R1

Reference Transcript

RefSeq:NM_014931.3 PPP6R1

Other Identifiers

11718431_x_at

11747158_a_at

16875683

209229_PM_s_at

209229_s_at

22870

36862_at

3871255

3871257

3871258

3871259

3871260

3871261

3871262

3871263

3871264

3871265

3871266

3871267

3871274

3871275

3871277

3871278

3871279

3871280

3871281

3871283

3871284

3871285

3871286

3871288

3871290

3871291

3871292

3871293

3871296

3871297

3871300

3871301

8039413

A_23_P119448

GE81976

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0019888

GO:0019903

GO:0031267

GO:0036211

GO:0043226

GO:0043666

GO:0098772

HMNXSV003057843

ILMN_1794085

PH_hs_0024883

TC19001864.hg

g12803904_3p_a_at

Participates

as a member of

PPP6R1,3 [cytosol] (Homo sapiens)

Inferred To

SAP185 [cytosol] (Saccharomyces cerevisiae)

SAP190 [cytosol] (Saccharomyces cerevisiae)

Ppp6r1 [cytosol] (Mus musculus)

Homologues of PPP6R1 [cytosol] (Saccharomyces cerevisiae)

ppp6r1 [cytosol] (Xenopus tropicalis)

SAP155 [cytosol] (Saccharomyces cerevisiae)

SAP4 [cytosol] (Saccharomyces cerevisiae)

PPP6R1 [cytosol] (Bos taurus)

PPP6R1 [cytosol] (Canis familiaris)

PPP6R1 [cytosol] (Dictyostelium discoideum)

PPP6R1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_055746.3

OpenTargets

ENSG00000105063

HPA

ENSG00000105063-PPP6R1

GeneCards

Q9UPN7

Ensembl

ENSG00000105063, ENST00000412770, ENSP00000414202, ENST00000587283, ENSP00000467521

PRO

Q9UPN7

Pharos - Targets

Q9UPN7

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08173 CHRM4	1	CHRM4 [plasma membrane] (R-HSA-390693)	0.527	2
UniProt:Q14694 USP10	3	USP10 [nucleoplasm] (R-HSA-3222218) K63polyUb-USP10 [cytosol] (R-HSA-6782986) USP10 [cytosol] (R-HSA-6782974)	0.483	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	10

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