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DARS [cytosol]
Stable Identifier
R-HSA-379605
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Aspartyl-tRNA synthetase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Selenoamino acid metabolism (Homo sapiens)
tRNA(Met) is selenomethionylated to SeMet-tRNA(Met) by multisynthetase complex (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
DARS homodimer [cytosol] (Homo sapiens)
DARS [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
tRNA Aminoacylation (Homo sapiens)
Cytosolic tRNA aminoacylation (Homo sapiens)
arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
DARS homodimer [cytosol] (Homo sapiens)
DARS [cytosol] (Homo sapiens)
aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate (Homo sapiens)
DARS homodimer [cytosol] (Homo sapiens)
DARS [cytosol] (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
DARS homodimer [cytosol] (Homo sapiens)
DARS [cytosol] (Homo sapiens)
glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
DARS homodimer [cytosol] (Homo sapiens)
DARS [cytosol] (Homo sapiens)
glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
DARS homodimer [cytosol] (Homo sapiens)
DARS [cytosol] (Homo sapiens)
isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
DARS homodimer [cytosol] (Homo sapiens)
DARS [cytosol] (Homo sapiens)
leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
DARS homodimer [cytosol] (Homo sapiens)
DARS [cytosol] (Homo sapiens)
lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
DARS homodimer [cytosol] (Homo sapiens)
DARS [cytosol] (Homo sapiens)
methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
DARS homodimer [cytosol] (Homo sapiens)
DARS [cytosol] (Homo sapiens)
proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate (Homo sapiens)
aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
DARS homodimer [cytosol] (Homo sapiens)
DARS [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14868 DARS1
Gene Names
DARS1, DARS, PIG40
Chain
chain:1-501
Reference Genes
BioGPS Gene:1615 DARS1
CTD Gene:1615 DARS1
dbSNP Gene:1615 DARS1
ENSEMBL:ENSG00000115866 DARS
HGNC:2678 DARS1
KEGG Gene (Homo sapiens):1615 DARS1
Monarch:1615 DARS1
NCBI Gene:1615 DARS1
OMIM:603084 DARS1
UCSC:P14868 DARS1
Reference Transcript
RefSeq:NM_001349.3 DARS1
RefSeq:NM_001293312.1 DARS1
Other Identifiers
0002940056
11746468_a_at
11746469_x_at
11756661_a_at
1615
16903111
201623_PM_s_at
201623_s_at
201624_PM_at
201624_at
2577955
2577957
2577959
2577960
2577964
2577965
2577968
2577970
2577972
2577974
2577975
2577977
2577985
2577987
2577992
2577994
2577999
2578000
2578002
2578003
2578004
32615_at
45961_i_at
45962_r_at
8055445
A_23_P108415
A_33_P3531857
GE57523
GO:0000166
GO:0003674
GO:0003676
GO:0003723
GO:0004046
GO:0004812
GO:0004815
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005829
GO:0006399
GO:0006412
GO:0006418
GO:0006422
GO:0006520
GO:0008150
GO:0009058
GO:0016020
GO:0016810
GO:0016874
GO:0017101
GO:0022607
GO:0032991
GO:0034641
GO:0043167
GO:0043226
GO:0044281
GO:0045202
GO:0065003
GO:0070062
HMNXSV003004553
ILMN_1813836
J05032_at
PH_hs_0022093
TC02002377.hg
g12653688_3p_a_at
Participates
as a component of
DARS homodimer [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_001280241.1
,
NP_001340.2
OpenTargets
ENSG00000115866
HPA
ENSG00000115866-DARS1
GeneCards
P14868
Ensembl
ENSG00000115866
,
ENST00000264161
,
ENSP00000264161
PRO
P14868
Pharos - Targets
P14868
Orphanet
22394
PDB
4J15
,
5Y6L
,
6IY6
HMDB Protein
HMDBP00608
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.564
2
UniProt:Q08050 FOXM1
3
p-T611,S730,S739-FOXM1 [nucleoplasm]
(R-HSA-4088133)
p-T611-FOXM1 [nucleoplasm]
(R-HSA-4088026)
FOXM1 [nucleoplasm]
(R-HSA-4088019)
0.499
2
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.462
2
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