Reactome | DARS [cytosol]

DARS [cytosol]

Stable Identifier

R-HSA-379605

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Aspartyl-tRNA synthetase

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- MITF-M-regulated melanocyte development (Homo sapiens)
  - Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
    - MAPK-dependent phosphorylation of KARS (Homo sapiens)
      - KARS-depleted MSC [cytosol] (Homo sapiens)
        
        DARS homodimer [cytosol] (Homo sapiens)
        
        DARS [cytosol] (Homo sapiens)
      - aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
        
        DARS homodimer [cytosol] (Homo sapiens)
        
        DARS [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P14868 DARS1

Gene Names

DARS1, DARS, PIG40

Chain

chain:1-501

Reference Genes

BioGPS Gene:1615 DARS1

CTD Gene:1615 DARS1

dbSNP Gene:1615 DARS1

ENSEMBL:ENSG00000115866 DARS

ENSEMBL_homo_sapiens_GENE:ENSG00000115866.11 DARS1

HGNC:2678 DARS1

KEGG Gene (Homo sapiens):1615 DARS1

Monarch:1615 DARS1

NCBI Gene:1615 DARS1

OMIM:603084 DARS1

UCSC:P14868 DARS1

Reference Transcript

Other Identifiers

11746468_a_at

11746469_x_at

11756661_a_at

1615

16903111

201623_PM_s_at

201623_s_at

201624_PM_at

201624_at

2577955

2577957

2577959

2577960

2577964

2577965

2577968

2577970

2577972

2577974

2577975

2577977

2577985

2577987

2577992

2577994

2577999

2578000

2578002

2578003

2578004

32615_at

45961_i_at

45962_r_at

8055445

A_23_P108415

A_33_P3531857

GE57523

GO:0000166

GO:0003676

GO:0003723

GO:0003824

GO:0004046

GO:0004812

GO:0004815

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0006399

GO:0006412

GO:0006418

GO:0006422

GO:0006520

GO:0016020

GO:0016787

GO:0016874

GO:0017101

GO:0043226

GO:0045202

GO:0065003

GO:0070062

GO:0140098

HMNXSV003004553

ILMN_1813836

J05032_at

PH_hs_0022093

TC02002377.hg

g12653688_3p_a_at

Participates

as a component of

DARS homodimer [cytosol] (Homo sapiens)

Inferred To

DARS [cytosol] (Dictyostelium discoideum)

DARS [cytosol] (Gallus gallus)

DARS [cytosol] (Mus musculus)

DARS [cytosol] (Rattus norvegicus)

DARS1 [cytosol] (Bos taurus)

DARS1 [cytosol] (Canis familiaris)

DARS1 [cytosol] (Sus scrofa)

AspRS [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001340.2, NP_001280241.1

OpenTargets

ENSG00000115866

GeneCards

P14868

HPA

ENSG00000115866-DARS1

Ensembl

ENST00000264161, ENSG00000115866, ENSP00000264161

PRO

P14868

Pharos - Targets

P14868

Orphanet

22394

PDB

5Y6L, 4J15, 6IY6

HMDB Protein

HMDBP00608

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	16
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.564	2
UniProt:Q08050 FOXM1	3	p-T611,S730,S739-FOXM1 [nucleoplasm] (R-HSA-4088133) p-T611-FOXM1 [nucleoplasm] (R-HSA-4088026) FOXM1 [nucleoplasm] (R-HSA-4088019)	0.499	2
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.462	2