Reactome | EIF5 [cytosol]

EIF5 [cytosol]

Stable Identifier

R-HSA-72616

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF5, eukaryotic translation initiation factor 5, Eukaryotic translation initiation factor 5, eIF-5

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External Reference Information

External Reference

UniProt:P55010 EIF5

Gene Names

EIF5

Chain

chain:1-431

Reference Genes

BioGPS Gene:1983 EIF5

COSMIC (genes):EIF5 EIF5

CTD Gene:1983 EIF5

dbSNP Gene:1983 EIF5

ENSEMBL:ENSG00000100664 EIF5

HGNC:3299 EIF5

KEGG:hsa:1983 EIF5

Monarch:1983 EIF5

NCBI Gene:1983 EIF5

OMIM:601710 EIF5

UCSC:P55010 EIF5

Reference Transcript

Other Identifiers

11724724_a_at

11724725_a_at

11724726_s_at

11724727_a_at

11741224_s_at

11758020_s_at

11758275_s_at

11763890_at

16789178

16789207

167_at

1983

208290_PM_s_at

208290_s_at

208705_PM_s_at

208705_s_at

208706_PM_s_at

208706_s_at

208707_PM_at

208707_at

208708_PM_x_at

208708_x_at

241843_PM_at

241843_at

32171_at

3553619

3553620

3553621

3553622

3553623

3553624

3553625

3553626

3553627

3553628

3553629

3553630

3553631

3553632

3553633

3553634

3553635

3553636

3553637

3553638

3553639

3553640

3553641

3553642

3553643

3553644

3553645

3553646

3553647

3553648

3553649

3553650

3553651

3553652

3553653

3553654

3553655

3553687

3882824

3999211

3999212

51379_at

53809_at

7977058

7977075

A_14_P114933

A_23_P205265

A_24_P398810

A_24_P415959

GE84166

GE86973

GE86974

GO:0001732

GO:0003723

GO:0003743

GO:0005092

GO:0005096

GO:0005515

GO:0005525

GO:0005737

GO:0005829

GO:0005886

GO:0006412

GO:0006413

GO:0006446

GO:0042255

GO:0045182

GO:0045202

GO:0045296

GO:0065003

GO:0071074

GO:0098772

HMNXSV003012350

HMNXSV003034967

Hs.186541.0.A1_3p_at

Hs.286236.1.S1_3p_a_at

Hs.286236.1.S3_3p_s_at

Hs.286236.1.S4_3p_at

ILMN_1657769

ILMN_1786734

ILMN_1815733

ILMN_2318430

PH_hs_0030187

RNA33538|snoRNA_scaRNA_134_126

TC14000797.hg

TC14000798.hg

U49436_at

g4503542_3p_s_at

Participates

as an output of

as an input of

This entity regulates

Positively

eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)

Inferred To

EIF5 [cytosol] (Bos taurus)

EIF5 [cytosol] (Caenorhabditis elegans)

EIF5 [cytosol] (Canis familiaris)

EIF5 [cytosol] (Gallus gallus)

EIF5 [cytosol] (Plasmodium falciparum)

EIF5 [cytosol] (Sus scrofa)

TIF5 [cytosol] (Saccharomyces cerevisiae)

eif5 [cytosol] (Danio rerio)

eif5 [cytosol] (Dictyostelium discoideum)

eif5 [cytosol] (Xenopus tropicalis)

tif5 [cytosol] (Schizosaccharomyces pombe)

eIF5 [cytosol] (Drosophila melanogaster)

Eif5 [cytosol] (Mus musculus)

Eif5 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001960.2, NP_892116.2

ENSEMBL

ENSG00000100664, ENST00000392715, ENST00000216554, ENSP00000453743, ENSP00000216554, ENSP00000376477, ENST00000558506

OpenTargets

ENSG00000100664

GeneCards

EIF5

HPA

ENSG00000100664-EIF5

PRO

P55010

Pharos - Targets

P55010

GlyGen

P55010

HMDB Protein

HMDBP08454

PDB

8PJ2, 8PJ3, 8OZ0, 2IU1, 2E9H, 2G2K

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UNI6 DUS12			0.718	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:O14863 ZNT4			0.527	2
UniProt:P47813 EIF1AX	1	EIF1AX [cytosol] (R-HSA-72557)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	6