Reactome | ADAM17(215-827) [Golgi membrane]

ADAM17(215-827) [Golgi membrane]

Stable Identifier

R-HSA-9662839

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

ADAM 17 metalloprotease, ADAM 17 sheddase, TACE

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P78536 ADAM17

Gene Names

ADAM17, CSVP, TACE

Chain

signal peptide:1-17, propeptide:18-214, chain:215-824

Reference Genes

BioGPS Gene:6868 ADAM17

COSMIC (genes):ADAM17 ADAM17

CTD Gene:6868 ADAM17

dbSNP Gene:6868 ADAM17

ENSEMBL:ENSG00000151694 ADAM17

ENSEMBL_homo_sapiens_GENE:ENSG00000151694.15 ADAM17

HGNC:195 ADAM17

KEGG Gene (Homo sapiens):6868 ADAM17

Monarch:6868 ADAM17

NCBI Gene:6868 ADAM17

OMIM:603639 ADAM17

UCSC:P78536 ADAM17

Reference Transcript

RefSeq:NM_003183.5 ADAM17

Other Identifiers

11731109_a_at

11731110_at

11747645_a_at

1226_at

1227_g_at

16894335

205745_PM_x_at

205745_x_at

205746_PM_s_at

205746_s_at

213532_PM_at

213532_at

2539822

2539823

2539824

2539825

2539826

2539828

2539829

2539833

2539834

2539835

2539836

2539838

2539839

2539840

2539841

2539844

2539846

2539849

2539850

2539852

2539855

2539856

2539857

41601_at

6868

8050190

A_23_P143120

A_24_P157053

A_32_P129621

GE59572

GO:0000139

GO:0000278

GO:0001666

GO:0002376

GO:0002446

GO:0002467

GO:0002690

GO:0003824

GO:0004175

GO:0004222

GO:0005112

GO:0005138

GO:0005178

GO:0005515

GO:0005737

GO:0005783

GO:0005788

GO:0005794

GO:0005829

GO:0005856

GO:0005886

GO:0005911

GO:0005925

GO:0006508

GO:0006509

GO:0007155

GO:0007219

GO:0007220

GO:0008233

GO:0008237

GO:0008284

GO:0009410

GO:0009986

GO:0010820

GO:0012501

GO:0015629

GO:0016020

GO:0016324

GO:0016485

GO:0016787

GO:0017124

GO:0019538

GO:0023052

GO:0030154

GO:0030165

GO:0030183

GO:0030307

GO:0030335

GO:0030512

GO:0032496

GO:0032587

GO:0032722

GO:0033025

GO:0033077

GO:0033627

GO:0035313

GO:0036211

GO:0042060

GO:0042987

GO:0043120

GO:0043226

GO:0043536

GO:0045121

GO:0045737

GO:0045741

GO:0045742

GO:0046872

GO:0048536

GO:0048856

GO:0048870

GO:0050830

GO:0050896

GO:0051128

GO:0051604

GO:0071403

GO:0071679

GO:0098542

GO:0120163

GO:0140096

GO:1900087

GO:1902945

GO:1903265

GO:1905564

HMNXSV003048247

Hs.52438.1.A1_3p_at

ILMN_1765779

ILMN_2121068

PH_hs_0024641

TC02001558.hg

U69611_at

U86755_s_at

g11497003_3p_a_at

g1857672_3p_a_at

Participates

as an input of

ADAM17 binds Zn2+ (Homo sapiens)

as a component of

ADAM17(215-827):Zn2+ [Golgi membrane] (Homo sapiens)

as an output of

FURIN cleaves ADAM17 (Homo sapiens)

Other forms of this molecule

ADAM17 [endoplasmic reticulum lumen]

ADAM17(1-214) [Golgi membrane]

ADAM17 [Golgi membrane]

ADAM17(215-827) [plasma membrane]

ADAM17 [plasma membrane]

Cross References

RefSeq

NP_003174.3

ZINC - World Drugs

ADA17_HUMAN

Guide to Pharmacology - Targets

1662

OpenTargets

ENSG00000151694

ZINC - Substances

ADA17_HUMAN

ZINC target

P78536

PRO

P78536

PDB

3EDZ, 3E8R, 3EWJ, 2A8H, 2FV5, 2OI0, 2FV9, 3O64, 8CQY, 2M2F, 3LGP, 3B92, 1ZXC, 3LE9, 2I47, 3L0T, 3G42, 3L0V, 3KMC, 3CKI, 3KME, 1BKC, 2DDF, 3LEA

ZINC - Investigational

ADA17_HUMAN

IntEnz

3.4.24.86

GeneCards

P78536

HPA

ENSG00000151694-ADAM17

Ensembl

ENST00000310823, ENSG00000151694, ENSP00000309968

Pharos - Targets

P78536

Orphanet

21088

ZINC - Predictions - Purchasable

ADA17_HUMAN

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12959 DLG1	4	DLG1 [cytosol] (R-HSA-416332) DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [plasma membrane] (R-HSA-375977)	0.65	7
UniProt:P05556 ITGB1	2	ITGB1 [endosome membrane] (R-HSA-9611157) ITGB1 [plasma membrane] (R-HSA-57596)	0.609	2
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.597	3
UniProt:Q13257 MAD2L1	2	MAD2L1 [cytosol] (R-HSA-141400) Activated MAD2L1 [cytosol] (R-HSA-141447)	0.581	3
UniProt:Q80WQ6 RHDF2			0.524	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	5