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Ac-K21,K30 HINT1 [nucleoplasm]
Stable Identifier
R-HSA-9825685
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
fullName evidence="27"Adenosine 5'-monophosphoramidase HINT1 ecNumber evidence="6 8 9 10 16 17"3.9.1.-/ecNumber, HINT1_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
CREBBP acetylates HINT1 dimer (Homo sapiens)
Ac-K21, K30 HINT1 dimer [nucleoplasm] (Homo sapiens)
Ac-K21,K30 HINT1 [nucleoplasm] (Homo sapiens)
SIRT1 deacetylates HINT1 dimer (Homo sapiens)
Ac-K21, K30 HINT1 dimer [nucleoplasm] (Homo sapiens)
Ac-K21,K30 HINT1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49773 HINT1
Gene Names
HINT1, HINT, PKCI1, PRKCNH1
Chain
initiator methionine:, chain:2-126
Reference Genes
BioGPS Gene:3094 HINT1
COSMIC (genes):HINT1 HINT1
CTD Gene:3094 HINT1
dbSNP Gene:3094 HINT1
ENSEMBL:ENSG00000169567 HINT1
HGNC:4912 HINT1
KEGG:hsa:3094 HINT1
Monarch:3094 HINT1
NCBI Gene:3094 HINT1
OMIM:601314 HINT1
UCSC:P49773 HINT1
Reference Transcript
RefSeq:NM_005340.6 HINT1
Other Identifiers
1009_at
11741813_s_at
11741814_x_at
11753759_x_at
11757222_at
11757319_x_at
1555960_PM_at
1555960_at
1555961_PM_a_at
1555961_a_at
16651361
16651363
16651365
16651367
16651369
16651371
16651373
16651375
16651377
16651379
16651385
16651387
16999572
18670212
18670213
18670214
18670215
18670216
18670217
18670218
18670219
18670220
18670221
18670222
200093_PM_s_at
200093_s_at
207721_PM_x_at
207721_x_at
208826_PM_x_at
208826_x_at
2874685
2874687
2874688
2874689
2874690
2874691
2874692
2874693
2874694
2874695
2874696
2874697
2874699
2874701
2874702
2874703
2874706
2874715
2874717
2874719
2874721
2874727
2874729
2874739
3077268
3094
7893001
7893058
7893416
7893686
7893827
7893963
7894474
7894974
7895186
7895418
7896365
7896561
8113873
8113879
A_32_P336445
A_32_P47554
GE80125
GE88685
GO:0000118
GO:0000166
GO:0003824
GO:0005080
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0006355
GO:0006508
GO:0006915
GO:0007165
GO:0008234
GO:0009154
GO:0012501
GO:0016787
GO:0016926
GO:0016929
GO:0043226
GO:0043530
GO:0050850
GO:0055086
GO:0070062
GO:0072332
GO:0140096
GO:1901135
HMNXSV003022648
Hs.256697.2.A1_3p_a_at
ILMN_1807710
PH_hs_0039519
TC05001758.hg
TC05003229.hg
U51004_at
g4885412_3p_s_at
p25345
Participates
as a component of
Ac-K21, K30 HINT1 dimer [nucleoplasm] (Homo sapiens)
Other forms of this molecule
HINT1 [nucleoplasm]
Inferred To
LOC100684571 [nucleoplasm]
(Canis familiaris)
HINT1 [nucleoplasm]
(Bos taurus)
HINT1 [nucleoplasm]
(Drosophila melanogaster)
HINT1 [nucleoplasm]
(Sus scrofa)
chPKCI [nucleoplasm]
(Gallus gallus)
hint1 [nucleoplasm]
(Danio rerio)
hint1 [nucleoplasm]
(Xenopus tropicalis)
Ac-K21,K30 HINT1 [nucleoplasm]
(Bos taurus)
Ac-K21,K30 HINT1 [nucleoplasm]
(Canis familiaris)
Ac-K21,K30 HINT1 [nucleoplasm]
(Dictyostelium discoideum)
Ac-K21,K30 HINT1 [nucleoplasm]
(Mus musculus)
Ac-K21,K30 HINT1 [nucleoplasm]
(Plasmodium falciparum)
Ac-K21,K30 HINT1 [nucleoplasm]
(Rattus norvegicus)
hint-1 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of Ac-K21,K30 HINT1 [nucleoplasm]
(Bos taurus)
Homologues of Ac-K21,K30 HINT1 [nucleoplasm]
(Canis familiaris)
Modified Residues
Name
N6-acetyl-L-lysine at 21
Coordinate
21
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 30
Coordinate
30
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Cross References
OpenTargets
ENSG00000169567
ENSEMBL
ENSP00000304229
,
ENSG00000169567
,
ENST00000304043
HPA
ENSG00000169567-HINT1
GeneCards
HINT1
ZINC - Substances
HINT1_HUMAN
ZINC target
P49773
PRO
P49773
Pharos - Targets
P49773
GlyGen
P49773
HMDB Protein
HMDBP01653
PDB
5KM2
,
1KPF
,
6N3Y
,
8PA6
,
1KPC
,
8P8P
,
5IPC
,
5I2F
,
5KM6
,
5I2E
,
5KM4
,
5KMC
,
6G9Z
,
5KLY
,
5KMB
,
5KMA
,
5KLZ
,
5ED6
,
5IPE
,
6N3X
,
6N3V
,
6J53
,
8PAI
,
6J5S
,
4ZKV
,
5WAA
,
4EQG
,
6J5Z
,
4EQH
,
5KM1
,
1KPE
,
1KPA
,
7Q2U
,
8PA9
,
5KM0
,
5IPB
,
1KPB
,
6YQM
,
8WZD
,
8PAF
,
4ZKL
,
5KM3
,
6B42
,
5WA8
,
5O8I
,
5IPD
,
1AV5
,
5EMT
,
6N3W
,
5WA9
,
8PWK
,
6J58
,
3TW2
,
6J65
,
6J64
,
5ED3
,
4EQE
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96RR4 CAMKK2
4
p-CAMKK2 [nucleoplasm]
(R-HSA-9618968)
CAMKK2 [nucleoplasm]
(R-HSA-5336483)
CAMKK2 [cytosol]
(R-HSA-9619231)
p-CAMKK2 [cytosol]
(R-HSA-9619358)
0.527
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
11
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