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SLC25A11 [mitochondrial inner membrane]
Stable Identifier
R-HSA-198451
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
Mitochondrial 2-oxoglutarate/malate carrier protein
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Malate-aspartate shuttle (Homo sapiens)
SLC25A11 exchanges 2-OG and MAL (Homo sapiens)
SLC25A11 homodimer [mitochondrial inner membrane] (Homo sapiens)
SLC25A11 [mitochondrial inner membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
SLC-mediated transport of organic anions (Homo sapiens)
Organic anion transport by SLC5/17/25 transporters (Homo sapiens)
SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane (Homo sapiens)
SLC25A11 homodimer [mitochondrial inner membrane] (Homo sapiens)
SLC25A11 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q02978 SLC25A11
Gene Names
SLC25A11, SLC20A4
Chain
initiator methionine:1, chain:2-314
Reference Genes
BioGPS Gene:8402 SLC25A11
COSMIC - genes:SLC25A11 SLC25A11
CTD Gene:8402 SLC25A11
dbSNP Gene:8402 SLC25A11
ENSEMBL:ENSG00000108528 SLC25A11
HGNC:10981 SLC25A11
KEGG:hsa:8402 SLC25A11
Monarch:8402 SLC25A11
NCBI Gene:8402 SLC25A11
OMIM:604165 SLC25A11
UCSC:Q02978 SLC25A11
Reference Transcript
RefSeq:NM_001165418.2 SLC25A11
RefSeq:NM_003562.4 SLC25A11
Other Identifiers
11744261_a_at
11754024_a_at
11756183_x_at
16840145
207088_PM_s_at
207088_s_at
209003_PM_at
209003_at
32197_at
3742376
3742385
3742386
3742387
3742388
3742389
3742390
3742391
3742392
3742393
3742394
3742395
3742396
3742397
3742398
3742399
8011747
8402
A_23_P38497
GE61714
GO:0003723
GO:0005515
GO:0005634
GO:0005739
GO:0005743
GO:0005886
GO:0005975
GO:0006094
GO:0006869
GO:0015139
GO:0015297
GO:0015367
GO:0015742
GO:0016020
GO:0022857
GO:0043490
GO:0055085
GO:0071423
HMNXSV003048613
ILMN_1664168
PH_hs_0010878
TC17001033.hg
TC17001034.hg
TC17001035.hg
X66114_rna1_at
g4506996_3p_a_at
p25996
p25997
Participates
as a component of
SLC25A11 homodimer [mitochondrial inner membrane] (Homo sapiens)
Inferred To
Homologues of SLC25A11 [mitochondrial inner membrane]
(Sus scrofa)
slc25a11 [mitochondrial inner membrane]
(Danio rerio)
slc25a11 [mitochondrial inner membrane]
(Xenopus tropicalis)
Slc25a11 [mitochondrial inner membrane]
(Mus musculus)
Slc25a11 [mitochondrial inner membrane]
(Rattus norvegicus)
SLC25A11 [mitochondrial inner membrane]
(Bos taurus)
SLC25A11 [mitochondrial inner membrane]
(Canis familiaris)
SLC25A11 [mitochondrial inner membrane]
(Plasmodium falciparum)
SLC25A11 [mitochondrial inner membrane]
(Sus scrofa)
misc-1 [mitochondrial inner membrane]
(Caenorhabditis elegans)
Dmel\CG1907 [mitochondrial inner membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001158890.1
,
NP_003553.2
Guide to Pharmacology - Targets
1053
ENSEMBL
ENST00000225665
,
ENSP00000225665
,
ENSG00000108528
,
ENSP00000440804
,
ENST00000544061
OpenTargets
ENSG00000108528
GeneCards
SLC25A11
HPA
ENSG00000108528-SLC25A11
PRO
Q02978
Pharos - Targets
Q02978
GlyGen
Q02978
Orphanet
SLC25A11
HMDB Protein
HMDBP01116
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.643
4
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
0.615
17
UniProt:P12830 CDH1
20
CDH1(732-882) [plasma membrane]
(R-HSA-3827997)
CDH1(155-700) [plasma membrane]
(R-HSA-2534244)
CDH1(701-882) [extracellular region]
(R-HSA-2534158)
Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8877002)
p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8876938)
PolyUbK48-CDH1 [plasma membrane]
(R-HSA-9934660)
PolyUbK48-CDH1 [early endosome membrane]
(R-HSA-9934659)
PolyUb-K740,K818-CDH1 [plasma membrane]
(R-HSA-9935242)
PolyUb-K740,K818-CDH1 [early endosome membrane]
(R-HSA-9935416)
PolyUb-K740,K818-CDH1 [lysosomal membrane]
(R-HSA-9935544)
Man,Man9GlucNAc2,p-3S,2Y-CDH1 [plasma membrane]
(R-HSA-9934836)
CDH1(155-882) [plasma membrane]
(R-HSA-198003)
CDH1(751-882) [plasma membrane]
(R-HSA-202929)
CDH1(155-750) [plasma membrane]
(R-HSA-202940)
Man9GlcNAc2-CDH1(23-882) [endoplasmic reticulum membrane]
(R-HSA-9932354)
Man,Man9GlucNAc2-CDH1(23-882) [endoplasmic reticulum membrane]
(R-HSA-9933097)
Glu1Man9GlcNAc2-CDH1(23-882) [endoplasmic reticulum membrane]
(R-HSA-9932915)
Glu2Man9GlcNAc2-CDH1(23-882) [endoplasmic reticulum membrane]
(R-HSA-9932341)
Glu3Man9GlcNAc2-CDH1(23-882) [endoplasmic reticulum membrane]
(R-HSA-9932178)
CDH1(23-882) [endoplasmic reticulum membrane]
(R-HSA-9932157)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
6
UniProt:P36957 DLST
5
Lipo-K110-DLST [mitochondrial matrix]
(R-HSA-69993)
GlutaryllipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9858581)
LipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853485)
SuccinyllipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853502)
DLST [mitochondrial matrix]
(R-HSA-6792574)
0.556
3
UniProt:P27797 CALR
6
CALR [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985502)
CALR [endoplasmic reticulum lumen]
(R-HSA-195905)
CALR [extracellular region]
(R-HSA-2197641)
CALR [endocytic vesicle lumen]
(R-HSA-2239448)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863866)
CALR [phagocytic vesicle membrane]
(R-HSA-1236879)
0.556
3
UniProt:Q15078 CDK5R1
4
MyrG-CDK5R1(2-307) [plasma membrane]
(R-HSA-421083)
CDK5R1(99-307) [nucleoplasm]
(R-HSA-6805262)
CDK5R1(99-307) [cytosol]
(R-HSA-8863415)
MyrG-CDK5R1(2-98) [plasma membrane]
(R-HSA-8863400)
0.556
3
UniProt:P60709 ACTB
5
ACTB [plasma membrane]
(R-HSA-196016)
ACTB [lysosomal membrane]
(R-HSA-196160)
ACTB [cytosol]
(R-HSA-201861)
ACTB [nucleoplasm]
(R-HSA-3321990)
Unfolded ACTB [cytosol]
(R-HSA-390462)
0.527
2
UniProt:Q7KZN9 COX15
1
COX15 [mitochondrial inner membrane]
(R-HSA-2995350)
0.527
2
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