Reactome | YES1 [cytosol]

YES1

Stable Identifier

R-HSA-373640

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proto-oncogene tyrosine-protein kinase Yes

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Axon guidance (Homo sapiens)
  - EPH-Ephrin signaling (Homo sapiens)
    - EPH-ephrin mediated repulsion of cells (Homo sapiens)
      - EPHA binds TIAM1 (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - SFKs phosphorylate VAV2,3 (Homo sapiens)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - p-EPHs bind VAV2,3 (Homo sapiens)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
    - EPHA-mediated growth cone collapse (Homo sapiens)
      - NGEF binds EPHA (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - NGEF exchanges GTP for GDP on RHOA (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - SFKs phosphorylate NGEF (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
    - EPHB-mediated forward signaling (Homo sapiens)
      - EPHB phosphorylates TIAM1 (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - EPHB:NMDAR binds TIAM1 (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - EPHBs bind NMDARs (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs:Glu:NMDAR:Gly [plasma membrane] (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - FYN phosphorylates NMDAR2B (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs:Glu:NMDAR:Gly [plasma membrane] (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Homo sapiens)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
    - p-EPHs bind SRC,FYN,YES,LYN (Homo sapiens)
      - SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
        
        SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by SCF-KIT (Homo sapiens)
    - Dimerization of STATs (Homo sapiens)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
    - Disassociation and translocation of STATs to the nucleus (Homo sapiens)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
    - GRB2 is indirectly recruited to p-KIT through SHP2 (Homo sapiens)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
    - Indirect recruitment of GAB2 to p-KIT (Homo sapiens)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
    - Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Homo sapiens)
      - PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
    - Interaction of Src family kinases with p-KIT (Homo sapiens)
      - SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
    - JAK2 binds to p-KIT (Homo sapiens)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
    - Phosphorylation and activation of VAV1 (Homo sapiens)
      - SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
    - Phosphorylation of GAB2 by SFKs (Homo sapiens)
      - GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
    - Phosphorylation of JAK2 (Homo sapiens)
      - JAK2:SFKS:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
    - Phosphorylation of SHP2 by SFKs (Homo sapiens)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
    - Phosphorylation of STATs (Homo sapiens)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
    - Phosphorylation of p-KIT on Y900 by Src kinases (Homo sapiens)
      - SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
    - Recruitment of STATs (Homo sapiens)
      - p-JAK2:SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
    - Regulation of KIT signaling (Homo sapiens)
      - Interaction of APS and p-KIT (Homo sapiens)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - Phosphorylation of APS (Homo sapiens)
        
        APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - Recruitment of CBL to KIT (Homo sapiens)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Homo sapiens)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Homo sapiens)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Homo sapiens)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
    - SHP2 interacts with p-KIT (Homo sapiens)
      - SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
      - SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)
    - Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)
      - PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
        
        SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
        
        Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
        
        YES1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P07947 YES1

Gene Names

YES1, YES

Chain

initiator methionine:1, chain:2-543

Reference Genes

BioGPS Gene:7525 YES1

COSMIC (genes):YES1 YES1

CTD Gene:7525 YES1

dbSNP Gene:7525 YES1

ENSEMBL:ENSG00000176105 YES1

HGNC:12841 YES1

KEGG Gene (Homo sapiens):hsa:7525 YES1

Monarch:7525 YES1

NCBI Gene:7525 YES1

OMIM:164880 YES1

UCSC:P07947 YES1

Reference Transcript

Other Identifiers

0006510079

04660+2.7.10.2

11719415_a_at

1674_at

16853445

202932_at

202933_s_at

2521765

26480

2HDA

3795943

3795944

3795945

3795946

3795950

3795952

3795954

3795958

3795959

3795962

3795965

3795966

3795967

3795970

3795971

3795990

3795993

3795994

3795995

3940656

3940657

3940661

4370

7525

8021984

A_23_P164507

A_24_P48403

AAA35735

AAH48960

AP001178

BC048960

CAB004370

CCDS11824

CH471113

EAX01709

EAX01710

ENSG00000176105

ENSP00000324740

ENSP00000462468

ENST00000314574

ENST00000584307

EntrezGene:7525

g4885660_3p_a_at

GE62489

GO:0000166

GO:0001784

GO:0002376

GO:0003013

GO:0003674

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005154

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005794

GO:0005815

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005925

GO:0006464

GO:0006468

GO:0006810

GO:0006950

GO:0007155

GO:0007165

GO:0007169

GO:0008150

GO:0008283

GO:0009058

GO:0010827

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0019899

GO:0030154

GO:0031234

GO:0031295

GO:0034641

GO:0036120

GO:0038083

GO:0038096

GO:0040011

GO:0042127

GO:0043114

GO:0043167

GO:0043226

GO:0044325

GO:0045087

GO:0045944

GO:0046777

GO:0048013

GO:0048870

GO:0050731

GO:0050900

GO:0055085

GO:0070062

GO:0071300

GO:0071560

HGNC:12841

HPA026480

ILMN_1691466

IPR000719

IPR000980

IPR001245

IPR001452

IPR008266

IPR011009

IPR017441

IPR020635

IPR035751

IPR036028

IPR036860

J3QRU1

M15990

M15990_at

MIM:164880

NM_005433

NP_005424

PF00017

PF00018

PF07714

PH_hs_0035676

PR00109

PR00401

PR00452

SM00219

SM00252

SM00326

TC18000278.hg

uc002kky.4

uc002kkz.4

UPI0000062316

XM_005258139

XP_005258196

YES1

YES1-201

YES1-205

Participant Of

hasCandidate

FYN-like kinases [cytosol]

hasMember

Other forms of this molecule

MyrG-p-Y426-YES1 [plasma membrane]

Inferred To

YES1 [cytosol] (Bos taurus)

YES1 [cytosol] (Caenorhabditis elegans)

YES1 [cytosol] (Canis familiaris)

YES1 [cytosol] (Danio rerio)

YES1 [cytosol] (Drosophila melanogaster)

YES1 [cytosol] (Gallus gallus)

YES1 [cytosol] (Mus musculus)

YES1 [cytosol] (Rattus norvegicus)

YES1 [cytosol] (Sus scrofa)

YES1 [cytosol] (Taeniopygia guttata)

YES1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_016881449.1, NP_005424.1

ZINC - World Drugs

YES_HUMAN

ZINC - FDA approved

YES_HUMAN

GeneCards

P07947

ZINC - Substances

YES_HUMAN

ZINC target

P07947

PRO

P07947

BRENDA (Homo sapiens)

2.7.10.2

ZINC - Predictions - Purchasable

YES_HUMAN

HMDB Protein

HMDBP01230

PDB

2HDA

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14543 SOCS3	1	SOCS3 [cytosol] (R-HSA-873794)	0.696	5
UniProt:Q9Y4K3 TRAF6	8	K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.696	5
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.564	3
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848)	0.556	3
UniProt:Q8IVP5 FUNDC1	4	p-S13,Y18-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934915) p-S17-FUNDC1 [mitochondrial outer membrane] (R-HSA-8948140) FUNDC1 [mitochondrial outer membrane] (R-HSA-8934922) p-S13-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934910)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.488	2
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.488	2
UniProt:P14136 GFAP	1	GFAP [cytosol] (R-HSA-1253311)	0.488	2
UniProt:P56945 BCAR1	4	p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y-BCAR1 [cytosol] (R-HSA-372645) BCAR1 [cytosol] (R-HSA-201625) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723)	0.488	2
UniProt:O60496 DOK2	1	DOK2 [cytosol] (R-HSA-204823)	0.488	2