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About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
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Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
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YES1 [cytosol]
Stable Identifier
R-HSA-373640
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Proto-oncogene tyrosine-protein kinase Yes
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
EPHA binds TIAM1 (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
SFKs phosphorylate VAV2,3 (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
p-EPHs bind VAV2,3 (Homo sapiens)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
EPHA-mediated growth cone collapse (Homo sapiens)
NGEF binds EPHA (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
NGEF exchanges GTP for GDP on RHOA (Homo sapiens)
EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
SFKs phosphorylate NGEF (Homo sapiens)
EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)
EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
EPHB phosphorylates TIAM1 (Homo sapiens)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Homo sapiens)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Homo sapiens)
EFNBs:p-EPHBs:SFKs [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Homo sapiens)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Homo sapiens)
EFNBs:p-EPHBs:SFKs [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
EPHB:NMDAR binds TIAM1 (Homo sapiens)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Homo sapiens)
EFNBs:p-EPHBs:SFKs [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Homo sapiens)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Homo sapiens)
EFNBs:p-EPHBs:SFKs [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
EPHBs bind NMDARs (Homo sapiens)
EFNBs:p-EPHBs:SFKs [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
EFNBs:p-EPHBs:SFKs:Glu:NMDAR:Gly [plasma membrane] (Homo sapiens)
EFNBs:p-EPHBs:SFKs [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
FYN phosphorylates NMDAR2B (Homo sapiens)
EFNBs:p-EPHBs:SFKs:Glu:NMDAR:Gly [plasma membrane] (Homo sapiens)
EFNBs:p-EPHBs:SFKs [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Homo sapiens)
EFNBs:p-EPHBs:SFKs [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Homo sapiens)
EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Homo sapiens)
EFNBs:p-EPHBs:SFKs [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
p-EPHs bind SRC,FYN,YES,LYN (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
SRC,FYN,YES,LYN [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
PECAM1 interactions (Homo sapiens)
Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CD28 co-stimulation (Homo sapiens)
Phosphorylation of CD28 (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
CTLA4 inhibitory signaling (Homo sapiens)
Phosphorylation of CTLA-4 (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
p-Y165,Y182-CTLA-4 dimer:SFKs [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
SHP2 phosphatase binds CTLA-4 (Homo sapiens)
p-Y165,Y182-CTLA-4 dimer:SFKs [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
pCTLA-4:Src kinases:SHP2 [plasma membrane] (Homo sapiens)
p-Y165,Y182-CTLA-4 dimer:SFKs [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
Regulation of signaling by CBL (Homo sapiens)
CBL is tyrosine phosphorylated (Homo sapiens)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
FYN-like kinases [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
FYN-like kinases [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
CBL ubiquitinates PI3K (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
FYN-like kinases [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
FYN-like kinases [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Homo sapiens)
FYN-like kinases [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
FYN-like kinases [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
FCGR activation (Homo sapiens)
Sequestering and phosphorylation Fc gamma receptors in the lipid rafts (Homo sapiens)
Src family kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Dimerization of STATs (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Disassociation and translocation of STATs to the nucleus (Homo sapiens)
p-JAK2:SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:p-STAT dimers [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
GRB2 is indirectly recruited to p-KIT through SHP2 (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Indirect recruitment of GAB2 to p-KIT (Homo sapiens)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Homo sapiens)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Interaction of Src family kinases with p-KIT (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
JAK2 binds to p-KIT (Homo sapiens)
JAK2:SFKS:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Phosphorylation and activation of VAV1 (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Phosphorylation of GAB2 by SFKs (Homo sapiens)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Phosphorylation of JAK2 (Homo sapiens)
JAK2:SFKS:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
p-JAK2:SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Phosphorylation of SHP2 by SFKs (Homo sapiens)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Phosphorylation of STATs (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:p-STATs [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Phosphorylation of p-KIT on Y900 by Src kinases (Homo sapiens)
SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Recruitment of STATs (Homo sapiens)
p-JAK2:SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
p-JAK2:SFKs:p-KIT complex:STATs [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Regulation of KIT signaling (Homo sapiens)
Interaction of APS and p-KIT (Homo sapiens)
APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Phosphorylation of APS (Homo sapiens)
APS dimer:p-c-Kit:SFKs complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
p-APS dimer:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Recruitment of CBL to KIT (Homo sapiens)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Homo sapiens)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Homo sapiens)
p-APS dimer:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Homo sapiens)
p-APS dimer:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
SHP2 interacts with p-KIT (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Src family tyrosine kinases (SFKs) [cytosol] (Homo sapiens)
YES1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07947 YES1
Gene Names
YES1, YES
Chain
initiator methionine:1, chain:2-543
Reference Genes
BioGPS Gene:7525 YES1
COSMIC (genes):YES1 YES1
CTD Gene:7525 YES1
dbSNP Gene:7525 YES1
ENSEMBL:ENSG00000176105 YES1
ENSEMBL_homo_sapiens_GENE:ENSG00000176105 YES1
HGNC:12841 YES1
KEGG Gene (Homo sapiens):7525 YES1
Monarch:7525 YES1
NCBI Gene:7525 YES1
OMIM:164880 YES1
UCSC:P07947 YES1
Reference Transcript
RefSeq:XM_017025960.1 YES1
RefSeq:NM_005433.3 YES1
Other Identifiers
0006510079
04660+2.7.10.2
11719415_a_at
1674_at
16853445
202932_at
202933_s_at
2521765
26480
2HDA
3795943
3795944
3795945
3795946
3795950
3795952
3795954
3795958
3795959
3795962
3795965
3795966
3795967
3795970
3795971
3795990
3795993
3795994
3795995
3940656
3940657
3940661
4370
7525
8021984
A_23_P164507
A_24_P48403
AAA35735
AAH48960
AP001178
BC048960
CAB004370
CCDS11824
CH471113
EAX01709
EAX01710
ENSG00000176105
ENSP00000324740
ENSP00000462468
ENST00000314574
ENST00000584307
EntrezGene:7525
g4885660_3p_a_at
GE62489
GO:0000166
GO:0001784
GO:0002376
GO:0003013
GO:0003674
GO:0004672
GO:0004713
GO:0004715
GO:0005102
GO:0005154
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005737
GO:0005794
GO:0005815
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005925
GO:0006464
GO:0006468
GO:0006810
GO:0007155
GO:0007165
GO:0007169
GO:0008150
GO:0009058
GO:0010827
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0019899
GO:0030154
GO:0031234
GO:0031295
GO:0034641
GO:0036120
GO:0038083
GO:0038096
GO:0040011
GO:0043114
GO:0043167
GO:0043226
GO:0044325
GO:0045944
GO:0046777
GO:0048013
GO:0048870
GO:0050731
GO:0050900
GO:0055085
GO:0070062
GO:0071300
GO:0071560
GO:0098978
GO:0099091
HGNC:12841
HPA026480
ILMN_1691466
IPR000719
IPR000980
IPR001245
IPR001452
IPR008266
IPR011009
IPR017441
IPR020635
IPR035751
IPR036028
IPR036860
J3QRU1
M15990
M15990_at
MIM:164880
NM_005433
NP_005424
PF00017
PF00018
PF07714
PH_hs_0035676
PR00109
PR00401
PR00452
SM00219
SM00252
SM00326
TC18000278.hg
uc002kky.4
uc002kkz.4
UPI0000062316
XM_005258139
XP_005258196
XP_024307011
XP_024307012
XP_024307013
XP_024307014
YES1
YES1-201
YES1-205
Participant Of
hasCandidate
FYN-like kinases [cytosol]
hasMember
Src family kinases (SFKs) [cytosol]
Src family tyrosine kinases (SFKs) [cytosol]
SRC,FYN,YES,LYN [cytosol]
Other forms of this molecule
MyrG-p-Y426-YES1 [plasma membrane]
Inferred To
YES1 [cytosol] (Bos taurus)
YES1 [cytosol] (Caenorhabditis elegans)
YES1 [cytosol] (Canis familiaris)
YES1 [cytosol] (Danio rerio)
YES1 [cytosol] (Drosophila melanogaster)
YES1 [cytosol] (Gallus gallus)
YES1 [cytosol] (Mus musculus)
YES1 [cytosol] (Rattus norvegicus)
YES1 [cytosol] (Sus scrofa)
YES1 [cytosol] (Taeniopygia guttata)
YES1 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
XP_016881449.1
,
NP_005424.1
ZINC - World Drugs
YES_HUMAN
OpenTargets
ENSG00000176105
ZINC - FDA approved
YES_HUMAN
ZINC - Substances
YES_HUMAN
ZINC target
P07947
ZINC - Biogenic
YES_HUMAN
PRO
P07947
PDB
2HDA
GeneCards
P07947
DOCK Blaster
2HDA
BRENDA (Homo sapiens)
2.7.10.2
ZINC - Predictions - Purchasable
YES_HUMAN
HMDB Protein
HMDBP01230
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y4K3 TRAF6
8
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [plasma membrane]
(R-HSA-936955)
TRAF6 [endosome membrane]
(R-HSA-450272)
0.696
5
UniProt:O14543 SOCS3
1
SOCS3 [cytosol]
(R-HSA-873794)
0.696
5
UniProt:P00533 EGFR
58
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.564
3
UniProt:Q8IVP5 FUNDC1
4
p-S13,Y18-FUNDC1 [mitochondrial outer membrane]
(R-HSA-8934915)
p-S17-FUNDC1 [mitochondrial outer membrane]
(R-HSA-8948140)
FUNDC1 [mitochondrial outer membrane]
(R-HSA-8934922)
p-S13-FUNDC1 [mitochondrial outer membrane]
(R-HSA-8934910)
0.556
3
UniProt:Q12933 TRAF2
5
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.488
2
UniProt:P56945 BCAR1
4
p-Y12-BCAR1 [cytosol]
(R-HSA-5218739)
p-Y-BCAR1 [cytosol]
(R-HSA-372645)
BCAR1 [cytosol]
(R-HSA-201625)
p-Y165,Y664-BCAR1 [cytosol]
(R-HSA-8848723)
0.488
2
UniProt:O60496 DOK2
1
DOK2 [cytosol]
(R-HSA-204823)
0.488
2
UniProt:P14136 GFAP
1
GFAP [cytosol]
(R-HSA-1253311)
0.488
2
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.488
2
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