Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SLC2A1 [plasma membrane]
Stable Identifier
R-HSA-70399
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
GLUT1, Solute carrier family 2, facilitated glucose transporter, member 1, Glucose transporter type 1, erythrocyte/brain, HepG2 glucose transporter
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2 (Homo sapiens)
GLUT1,2 [plasma membrane] (Homo sapiens)
GLUT1 / SLC2A1 tetramer [plasma membrane] (Homo sapiens)
SLC2A1 [plasma membrane] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Vitamin C (ascorbate) metabolism (Homo sapiens)
SLC2A1,3 transports DeHA from extracellular region to cytosol (Homo sapiens)
SLC2A1,3 [plasma membrane] (Homo sapiens)
SLC2A1 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Cellular hexose transport (Homo sapiens)
GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol (Homo sapiens)
GLUT1 / SLC2A1 tetramer [plasma membrane] (Homo sapiens)
SLC2A1 [plasma membrane] (Homo sapiens)
GLUT1 tetramer binds 4xATP (Homo sapiens)
GLUT1 / SLC2A1 tetramer [plasma membrane] (Homo sapiens)
SLC2A1 [plasma membrane] (Homo sapiens)
GLUT1:ATP tetramer [plasma membrane] (Homo sapiens)
GLUT1 / SLC2A1 tetramer [plasma membrane] (Homo sapiens)
SLC2A1 [plasma membrane] (Homo sapiens)
GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP (Homo sapiens)
GLUT1 / SLC2A1 tetramer [plasma membrane] (Homo sapiens)
SLC2A1 [plasma membrane] (Homo sapiens)
GLUT1:ATP tetramer [plasma membrane] (Homo sapiens)
GLUT1 / SLC2A1 tetramer [plasma membrane] (Homo sapiens)
SLC2A1 [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11681785
Structural analysis of the GLUT1 facilitative glucose transporter (review).
Hruz, PW
,
Mueckler, MM
Mol Membr Biol
2001
1562197
Mammalian facilitative glucose transporter family: structure and molecular regulation.
Pessin, JE
,
Bell, GI
Annu Rev Physiol
1992
External Reference Information
External Reference
UniProt:P11166 SLC2A1
Gene Names
SLC2A1, GLUT1
Chain
chain:1-492
Reference Genes
BioGPS Gene:6513 SLC2A1
COSMIC (genes):SLC2A1 SLC2A1
CTD Gene:6513 SLC2A1
dbSNP Gene:6513 SLC2A1
ENSEMBL:ENSG00000117394 SLC2A1
HGNC:11005 SLC2A1
KEGG:hsa:6513 SLC2A1
Monarch:6513 SLC2A1
NCBI Gene:6513 SLC2A1
OMIM:138140 SLC2A1
UCSC:P11166 SLC2A1
Reference Transcript
RefSeq:NM_006516.2 SLC2A1
Other Identifiers
11716815_at
11752572_a_at
11756056_a_at
11756238_s_at
16686060
201249_PM_at
201249_at
201250_PM_s_at
201250_s_at
2409109
2409110
2409111
2409112
2409113
2409114
2409115
2409116
2409117
2409118
2409119
2409120
2409122
2409123
2409124
2409125
2409126
2409127
2409128
2409129
2409130
2409131
2409132
2409133
2409138
2409139
2409143
2409144
2409145
2409150
2409153
2409154
2409155
40507_at
6513
7915472
81122_at
A_23_P571
A_32_P174130
A_33_P3344801
GE57541
GE85347
GO:0000139
GO:0001666
GO:0001674
GO:0001917
GO:0001939
GO:0003013
GO:0005215
GO:0005324
GO:0005355
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005901
GO:0005911
GO:0005975
GO:0006766
GO:0007417
GO:0007565
GO:0014704
GO:0015911
GO:0016020
GO:0016323
GO:0016324
GO:0019852
GO:0019900
GO:0021987
GO:0022414
GO:0022857
GO:0030018
GO:0030496
GO:0030864
GO:0031410
GO:0031982
GO:0032868
GO:0033300
GO:0042149
GO:0042383
GO:0042470
GO:0042802
GO:0042908
GO:0042910
GO:0043226
GO:0045121
GO:0045202
GO:0045494
GO:0046323
GO:0048856
GO:0055056
GO:0055085
GO:0065003
GO:0070062
GO:0070837
GO:0071260
GO:0071474
GO:0072562
GO:0098708
GO:0098793
GO:0150104
GO:1904016
GO:1904659
GO:1990350
HMNXSV003032649
HMNXSV003048639
ILMN_1659027
K03195_at
TC01002578.hg
g5730050_3p_a_at
Participates
as a component of
GLUT1 / SLC2A1 tetramer [plasma membrane] (Homo sapiens)
as a member of
SLC2A1,3 [plasma membrane] (Homo sapiens)
Other forms of this molecule
SLC2A1 [Golgi membrane]
SLC2A1 K256V [plasma membrane]
SLC2A1 Y449* [plasma membrane]
SLC2A1 R126L [plasma membrane]
SLC2A1 R223P [plasma membrane]
SLC2A1 K456* [plasma membrane]
SLC2A1 S342L [plasma membrane]
Inferred To
SLC2A1 [plasma membrane]
(Bos taurus)
SLC2A1 [plasma membrane]
(Caenorhabditis elegans)
SLC2A1 [plasma membrane]
(Canis familiaris)
SLC2A1 [plasma membrane]
(Dictyostelium discoideum)
SLC2A1 [plasma membrane]
(Drosophila melanogaster)
SLC2A1 [plasma membrane]
(Gallus gallus)
SLC2A1 [plasma membrane]
(Mus musculus)
SLC2A1 [plasma membrane]
(Plasmodium falciparum)
SLC2A1 [plasma membrane]
(Rattus norvegicus)
SLC2A1 [plasma membrane]
(Saccharomyces cerevisiae)
SLC2A1 [plasma membrane]
(Sus scrofa)
fdgt-2 [plasma membrane]
(Caenorhabditis elegans)
slc2a1a [plasma membrane]
(Danio rerio)
slcf-2 [plasma membrane]
(Caenorhabditis elegans)
symA [plasma membrane]
(Dictyostelium discoideum)
slc2a1 [plasma membrane]
(Xenopus tropicalis)
VPS73 [plasma membrane]
(Saccharomyces cerevisiae)
Homologues of SLC2A1 [plasma membrane]
(Caenorhabditis elegans)
Homologues of SLC2A1 [plasma membrane]
(Dictyostelium discoideum)
Homologues of SLC2A1 [plasma membrane]
(Plasmodium falciparum)
Homologues of SLC2A1 [plasma membrane]
(Saccharomyces cerevisiae)
Cross References
Guide to Pharmacology - Targets
875
OpenTargets
ENSG00000117394
ENSEMBL
ENST00000426263
,
ENSP00000416293
ZINC - Substances
GTR1_HUMAN
ZINC - Biogenic
GTR1_HUMAN
ZINC target
P11166
PRO
P11166
GlyGen
P11166
PDB
5EQH
,
5EQG
,
6THA
,
5EQI
,
4PYP
ZINC - Investigational
GTR1_HUMAN
ZINC - Metabolites
GTR1_HUMAN
HPA
ENSG00000117394-SLC2A1
Pharos - Targets
P11166
ZINC - Predictions - Purchasable
GTR1_HUMAN
Orphanet
SLC2A1
HMDB Protein
HMDBP02114
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text