Reactome | CHCHD3 [mitochondrial intermembrane space]

CHCHD3 [mitochondrial intermembrane space]

Stable Identifier

R-HSA-8874907

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial intermembrane space

Synonyms

MICOS complex subunit MIC19, MIC19_HUMAN

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
26416881	The Oxidation Status of Mic19 Regulates MICOS Assembly Sakowska, P, Chacinska, A, Jakobs, S, Jans, DC, Riedel, D, Mohanraj, K	Mol. Cell. Biol.	2015

External Reference Information

External Reference

UniProt:Q9NX63 CHCHD3

Gene Names

CHCHD3, MIC19, MINOS3

Chain

initiator methionine:, chain:2-227

Reference Genes

BioGPS Gene:54927 CHCHD3

COSMIC (genes):CHCHD3 CHCHD3

CTD Gene:54927 CHCHD3

dbSNP Gene:54927 CHCHD3

ENSEMBL:ENSG00000106554 CHCHD3

ENSEMBL_homo_sapiens_GENE:ENSG00000106554.13 CHCHD3

HGNC:21906 CHCHD3

KEGG Gene (Homo sapiens):54927 CHCHD3

Monarch:54927 CHCHD3

NCBI Gene:54927 CHCHD3

OMIM:613748 CHCHD3

UCSC:Q9NX63 CHCHD3

Reference Transcript

Other Identifiers

11757083_s_at

17063047

217972_PM_at

217972_at

2402993

2402994

2402995

3073634

3073643

3073663

3073675

3073703

3073704

3073713

3073717

3073722

3073723

3234481

46233_at

54927

8143028

A_23_P251927

GE55487

GO:0001401

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005739

GO:0005743

GO:0007005

GO:0007007

GO:0008053

GO:0016020

GO:0019902

GO:0042407

GO:0043226

GO:0044284

GO:0060090

GO:0061024

GO:0061617

GO:0070062

GO:0140275

HMNXSV003038176

ILMN_1673026

g8923389_3p_at

Participates

as a member of

Substrates of MIA40:ERV1 [mitochondrial intermembrane space] (Homo sapiens)

Other forms of this molecule

4xHC-CHCHD3 [mitochondrial intermembrane space]

CHCHD3 (MIC19) [mitochondrial inner membrane]

Cross References

RefSeq

NP_060282.1, NP_001304106.1

OpenTargets

ENSG00000106554

GeneCards

Q9NX63

HPA

ENSG00000106554-CHCHD3

Ensembl

ENST00000262570, ENSG00000106554, ENSP00000262570

PRO

Q9NX63

Pharos - Targets

Q9NX63

Interactors (53)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y512 SAMM50	1	SAMM50 [mitochondrial outer membrane] (R-HSA-1252178)	0.782	7
UniProt:Q9NW38 FANCL	2	FANCL [nucleoplasm] (R-HSA-419520) FANCL [cytosol] (R-HSA-420789)	0.718	6
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.718	6
UniProt:Q16891 IMMT	1	IMMT (MIC60) [mitochondrial inner membrane] (R-HSA-8949569)	0.643	3
UniProt:O75431 MTX2	1	MTX2 [mitochondrial outer membrane] (R-HSA-1252142)	0.643	4
UniProt:Q9BRQ6 CHCHD6	1	CHCHD6 (MIC25) [mitochondrial inner membrane] (R-HSA-8949568)	0.564	2
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.564	2
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P61970 NTF2			0.556	3
UniProt:Q96KN7 RPGR1			0.556	3
UniProt:P62140 PPP1CB	4	PPP1CB [cytosol] (R-HSA-163405) PPP1CB [nucleoplasm] (R-HSA-62003) PPP1CB P49R [cytosol] (R-HSA-9660547) PPP1CB A56P [cytosol] (R-HSA-9660543)	0.556	3
UniProt:Q53TS8 CTSRT			0.556	3
UniProt:Q13137 CACO2			0.556	3
UniProt:Q96R06 SPAG5			0.556	3
UniProt:Q5JVL4 EFHC1			0.556	3
UniProt:Q5VU43 MYOME			0.556	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:Q9H0I2 ENKD1			0.556	3
UniProt:Q9P209 CEP72	1	CEP72 [cytosol] (R-HSA-380321)	0.556	3
UniProt:Q9H6L4 ARMC7			0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:A8MQ03 CRTP1			0.556	6
IntAct:EBI-22314709 CCSB ORF ID			0.556	3
UniProt:Q8NEA9 GMCL2			0.556	3
UniProt:Q49AR9 Q49AR9			0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q8TAP4-4 LMO3			0.556	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.556	3
UniProt:Q9Y2D8 ADIP			0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	1	NOTCH2NLA [extracellular region] (R-HSA-9908935)	0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:Q15047-2 SETDB1			0.556	3
UniProt:Q8NA61 CBY2			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q96QF0 RAB3IP	1	RAB3IP [cytosol] (R-HSA-5617610)	0.556	3
IntAct:EBI-10171584 80125			0.556	3
UniProt:P25800 LMO1	1	LMO1 [nucleoplasm] (R-HSA-8956514)	0.556	3
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.544	2
UniProt:Q6UXV4 APOOL	3	APOOL (MIC27) [mitochondrial inner membrane] (R-HSA-8949612) APOOL [extracellular region] (R-HSA-8862979) APOOL [platelet alpha granule lumen] (R-HSA-8863003)	0.527	4
UniProt:O96008 TOMM40	3	TOMM40 [mitochondrial intermembrane space] (R-HSA-1267971) TOMM40 [cytosol] (R-HSA-1267992) TOMM40 [mitochondrial outer membrane] (R-HSA-1252082)	0.527	2
UniProt:Q9NVH1 DNAJC11	1	DNAJC11 [mitochondrial outer membrane] (R-HSA-8949572)	0.527	2
UniProt:Q15834 CC85B			0.508	2
UniProt:P61006 RAB8A	6	GGC-RAB8A [cytoplasmic vesicle membrane] (R-HSA-1445093) RAB8A [recycling endosome membrane] (R-HSA-8854145) GGC-RAB8A [trans-Golgi network membrane] (R-HSA-8876082) GGC-RAB8A [cytosol] (R-HSA-8874063) RAB8A [Golgi membrane] (R-HSA-2562535) RAB8A [cytosol] (R-HSA-5623399)	0.508	2
UniProt:P0DTD1-PRO_0000449629 REP			0.488	2
UniProt:Q8N6Y0 USBP1			0.488	2
UniProt:P14079 TAX			0.488	2
UniProt:Q15388 TOMM20	6	PolyUb-TOMM20 [mitochondrial outer membrane] (R-HSA-6783144) TOMM20 [mitochondrial outer membrane] (R-HSA-1252091) Ub-TOMM20 [mitochondrial outer membrane] (R-HSA-9834976) K48polyUb-TOMM20 [mitochondrial outer membrane] (R-HSA-9843324) K63polyUb-TOMM20 [mitochondrial outer membrane] (R-HSA-9843313) p-S65-Ub:TOMM20 [mitochondrial outer membrane] (R-HSA-9834948)	0.483	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6

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