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CFL1 [extracellular region]
Stable Identifier
R-HSA-350747
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Cofilin-1, COF1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Release of (inferred) platelet cytosolic components (Homo sapiens)
Platelet releasate (inferred) cytosolic proteins [extracellular region] (Homo sapiens)
CFL1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23528 CFL1
Gene Names
CFL1, Cofilin-1, CFL
Chain
initiator methionine:, chain:2-166
Reference Genes
BioGPS Gene:1072 CFL1
COSMIC (genes):CFL1 CFL1
CTD Gene:1072 CFL1
dbSNP Gene:1072 CFL1
ENSEMBL:ENSG00000172757 CFL1
HGNC:1874 CFL1
KEGG:hsa:1072 CFL1
Monarch:1072 CFL1
NCBI Gene:1072 CFL1
OMIM:601442 CFL1
UCSC:P23528 CFL1
Reference Transcript
RefSeq:NM_005507.2 CFL1
Other Identifiers
1072
11753645_a_at
11753646_x_at
11754158_a_at
11757818_x_at
11763259_x_at
1555730_PM_a_at
1555730_a_at
16654131
16654135
16654139
16654207
16654209
16654211
16654213
16654215
16654217
16654233
16654235
16654237
16654239
16654241
16654243
18671389
18671390
18671391
18671392
18671393
18671394
18671395
18671396
18671397
18671398
18671399
18671400
18671401
18671402
18671403
18671404
18671405
18671406
18671407
200021_PM_at
200021_at
236792_PM_at
236792_at
33659_at
3377887
3377888
3377889
3377890
3377891
3377892
3377893
3377894
3377895
3377896
3377897
3377898
3377899
3377900
3377901
3377902
3377904
3377905
3377906
3377910
3377912
3377914
3377916
75185_f_at
76366_at
76368_at
7892701
7894264
7895149
7895299
7895945
7896038
7949496
A_21_P0011012
GE79937
GE833765
GO:0000281
GO:0000910
GO:0003779
GO:0005515
GO:0005615
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0007010
GO:0007266
GO:0008092
GO:0009615
GO:0015629
GO:0016020
GO:0016363
GO:0022604
GO:0030027
GO:0030036
GO:0030042
GO:0030043
GO:0030424
GO:0030426
GO:0030479
GO:0031258
GO:0031982
GO:0032587
GO:0040019
GO:0042995
GO:0043066
GO:0043226
GO:0044794
GO:0051014
GO:0051015
GO:0051293
GO:0061001
GO:0070062
HMNXSV003014976
HMNXSV003053161
Hs.121449.0.A1_3p_at
Hs2.180370.2.S1_3p_s_at
ILMN_1705617
TC11001944.hg
TC11001945.hg
X95404_at
g5031634_3p_at
g5031634_3p_x_at
Participates
as a member of
Platelet releasate (inferred) cytosolic proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
CFL1 [cytosol]
p-S3-CFL1 [cytosol]
Cross References
RefSeq
NP_005498.1
OpenTargets
ENSG00000172757
ENSEMBL
ENSP00000309629
,
ENSP00000432660
,
ENST00000525451
,
ENST00000308162
HPA
ENSG00000172757-CFL1
PRO
P23528
Pharos - Targets
P23528
GlyGen
P23528
PDB
5L6W
,
3J0S
,
6UBY
,
6UC0
,
6VAO
,
1Q8X
,
6UC4
,
5HVK
,
1Q8G
,
4BEX
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60709 ACTB
5
ACTB [plasma membrane]
(R-HSA-196016)
ACTB [lysosomal membrane]
(R-HSA-196160)
ACTB [cytosol]
(R-HSA-201861)
ACTB [nucleoplasm]
(R-HSA-3321990)
Unfolded ACTB [cytosol]
(R-HSA-390462)
0.933
11
UniProt:P63261 ACTG1
3
ACTG1 [plasma membrane]
(R-HSA-196044)
ACTG1 [lysosomal membrane]
(R-HSA-196169)
ACTG1 [cytosol]
(R-HSA-201858)
0.831
10
UniProt:P53667 LIMK1
3
LIMK1 [cytosol]
(R-HSA-397785)
p-T508-LIMK1 [cytosol]
(R-HSA-399816)
p-S,T508-LIMK1 [cytosol]
(R-HSA-419610)
0.722
3
UniProt:P54253 ATX1
0.703
11
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.668
3
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.656
3
UniProt:P40123 CAP2
1
CAP2 [cytosol]
(R-HSA-428863)
0.643
4
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.577
4
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.577
3
UniProt:Q13393 PLD1
4
PLD1 [tertiary granule membrane]
(R-HSA-6800955)
PLD1 [specific granule membrane]
(R-HSA-6799531)
PLD1 [plasma membrane]
(R-HSA-2028998)
PLD1 [endoplasmic reticulum membrane]
(R-HSA-1498795)
0.571
4
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.569
10
UniProt:P68032 ACTC1
1
ACTC1 [cytosol]
(R-HSA-390536)
0.564
2
UniProt:Q1KLZ0 Q1KLZ0
0.556
3
UniProt:Q549N0 Q549N0
0.556
3
UniProt:Q96CV9 OPTN
6
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
OPTN [cytosol]
(R-HSA-9687907)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
0.556
3
UniProt:Q15303 ERBB4
0.553
2
UniProt:Q9Y281 COF2
0.547
3
UniProt:O14939 PLD2
2
PLD2 [plasma membrane]
(R-HSA-2029075)
PLD2 [endoplasmic reticulum membrane]
(R-HSA-1498791)
0.544
2
UniProt:P0DOE7 M
5
p-S95,T205-M [cytosol]
(R-RSY-9831678)
p-S95,T205-M [nucleoplasm]
(R-RSY-9831706)
M [nucleoplasm]
(R-RSY-9831711)
Nascent M [cytosol]
(R-RSY-9828672)
p-S95,T205-M [viral tegument]
(R-RSY-9836531)
0.524
2
UniProt:P57058 HUNK
0.524
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.499
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
12
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.462
2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
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