Reactome | CHTOP [nucleoplasm]

CHTOP [nucleoplasm]

Stable Identifier

R-HSA-8849147

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Chromatin target of PRMT1 protein, CHTOP_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
        
        CHTOP [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
        
        CHTOP [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y3Y2 CHTOP

Gene Names

CHTOP, C1orf77, FOP, HT031, PP7704

Chain

initiator methionine:1, chain:2-248

Reference Genes

BioGPS Gene:26097 CHTOP

COSMIC (genes):CHTOP CHTOP

CTD Gene:26097 CHTOP

dbSNP Gene:26097 CHTOP

ENSEMBL:ENSG00000160679.13 CHTOP

HGNC:24511 CHTOP

KEGG Gene (Homo sapiens):26097 CHTOP

Monarch:26097 CHTOP

NCBI Gene:26097 CHTOP

OMIM:614206 CHTOP

UCSC:Q9Y3Y2 CHTOP

Reference Transcript

Other Identifiers

11720299_s_at

11754759_a_at

11758829_s_at

16671166

202559_PM_x_at

202559_x_at

202560_PM_s_at

202560_s_at

209927_PM_s_at

209927_s_at

2359735

2359737

2359738

2359739

2359740

2359741

2359742

2359745

2359750

2359752

2359755

2359756

2359757

26097

33403_at

4043393

4043394

4043395

4043396

4043397

4043398

4043399

7905589

A_14_P134907

A_23_P138253

A_23_P201726

A_24_P265539

GE61596

GE79013

GO:0000346

GO:0001701

GO:0003677

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0006406

GO:0006913

GO:0008284

GO:0008327

GO:0016607

GO:0031062

GO:0032781

GO:0036211

GO:0036464

GO:0043226

GO:0048856

GO:0051028

GO:0051096

HMNXSV003016201

ILMN_1736234

PH_hs_0016120

TC01001259.hg

g12005923_3p_a_at

g7661589_3p_a_at

p33740

Participates

as an input of

TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)

as a component of

as an output of

Docking of the TAP:EJC Complex with the NPC (Homo sapiens)

Inferred To

Chtop [nucleoplasm] (Mus musculus)

Chtop [nucleoplasm] (Rattus norvegicus)

Chtopl1 [nucleoplasm] (Rattus norvegicus)

CHTOP [nucleoplasm] (Bos taurus)

CHTOP [nucleoplasm] (Canis familiaris)

CHTOP [nucleoplasm] (Schizosaccharomyces pombe)

CHTOP [nucleoplasm] (Sus scrofa)

Ghost homologue of CHTOP [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of CHTOP [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of CHTOP [nucleoplasm] (Gallus gallus)

Ghost homologue of CHTOP [nucleoplasm] (Xenopus tropicalis)

Homologues of CHTOP [nucleoplasm] (Rattus norvegicus)

Homologues of CHTOP [nucleoplasm] (Schizosaccharomyces pombe)

zgc:55292 [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_001304006.1, NP_056422.2, NP_001231593.1, NP_001193541.1

OpenTargets

ENSG00000160679

HPA

ENSG00000160679-CHTOP

GeneCards

Q9Y3Y2

Ensembl

ENSG00000160679, ENST00000368690, ENSP00000385228, ENST00000403433, ENSP00000357679, ENSP00000357683, ENST00000368694

PRO

Q9Y3Y2

Pharos - Targets

Q9Y3Y2

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13838 DDX39B	2	DDX39B [cytosol] (R-HSA-9715154) DDX39B [nucleoplasm] (R-HSA-8849139)	0.782	7
UniProt:P84090 ERH			0.675	4
UniProt:Q9UBU9 NXF1	2	NXF1 [cytosol] (R-HSA-156481) NXF1 [nucleoplasm] (R-HSA-111690)	0.653	9
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.59	2
UniProt:Q86V81 ALYREF	2	ALYREF [nucleoplasm] (R-HSA-156649) ALYREF [cytosol] (R-HSA-158482)	0.558	8
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.556	3
UniProt:Q16637 SMN1	2	SMN1 [nucleoplasm] (R-HSA-191892) SMN1 [cytosol] (R-HSA-191839)	0.556	3
UniProt:Q96SB4 SRPK1	1	SRPK1 [cytosol] (R-HSA-9729349)	0.527	2
UniProt:Q9UPE1 SRPK3			0.527	2
UniProt:Q9UKK6 NXT1	2	NXT1 [nucleoplasm] (R-HSA-8849151) NXT1 [cytosol] (R-HSA-8849122)	0.499	4
UniProt:Q13769 THOC5	3	p-Y-THOC5 [cytosol] (R-HSA-9682738) THOC5 [cytosol] (R-HSA-9682751) THOC5 [nucleoplasm] (R-HSA-8849111)	0.462	4
UniProt:Q96FV9 THOC1	1	THOC1 [nucleoplasm] (R-HSA-8849130)	0.462	4