Reactome | CHTOP [nucleoplasm]

CHTOP [nucleoplasm]

Stable Identifier

R-HSA-8849147

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Chromatin target of PRMT1 protein, CHTOP_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
        
        CHTOP [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        TREX (DDX39B:ATP) [nucleoplasm] (Homo sapiens)
        
        CHTOP [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y3Y2 CHTOP

Gene Names

CHTOP, C1orf77, FOP, HT031, PP7704

Chain

initiator methionine:, chain:2-248

Reference Genes

BioGPS Gene:26097 CHTOP

COSMIC (genes):CHTOP CHTOP

CTD Gene:26097 CHTOP

dbSNP Gene:26097 CHTOP

ENSEMBL:ENSG00000160679 CHTOP

HGNC:24511 CHTOP

KEGG:hsa:26097 CHTOP

Monarch:26097 CHTOP

NCBI Gene:26097 CHTOP

OMIM:614206 CHTOP

UCSC:Q9Y3Y2 CHTOP

Reference Transcript

Participates

as an input of

TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)

as a component of

as an output of

Docking of the TAP:EJC Complex with the NPC (Homo sapiens)

Inferred To

Chtop [nucleoplasm] (Mus musculus)

Chtop [nucleoplasm] (Rattus norvegicus)

CHTOP [nucleoplasm] (Canis familiaris)

CHTOP [nucleoplasm] (Sus scrofa)

Ghost homologue of CHTOP [nucleoplasm] (Bos taurus)

Ghost homologue of CHTOP [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of CHTOP [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of CHTOP [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of CHTOP [nucleoplasm] (Gallus gallus)

Cross References

ENSEMBL

ENST00000403433, ENST00000368694, ENST00000368690, ENSG00000160679, ENSP00000357683, ENSP00000385228, ENSP00000357679

OpenTargets

ENSG00000160679

GeneCards

CHTOP

HPA

ENSG00000160679-CHTOP

PRO

Q9Y3Y2

Pharos - Targets

Q9Y3Y2

GlyGen

Q9Y3Y2

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13838 DDX39B	2	DDX39B [nucleoplasm] (R-HSA-8849139) DDX39B [cytosol] (R-HSA-9715154)	0.831	8
UniProt:P84090 ERH			0.75	6
UniProt:Q9UBU9 NXF1	2	NXF1 [nucleoplasm] (R-HSA-111690) NXF1 [cytosol] (R-HSA-156481)	0.653	9
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.59	2
UniProt:Q99873 PRMT1	2	PRMT1 [cytosol] (R-HSA-9632173) PRMT1 [nucleoplasm] (R-HSA-3215140)	0.564	5
UniProt:Q86V81 ALYREF	2	ALYREF [cytosol] (R-HSA-158482) ALYREF [nucleoplasm] (R-HSA-156649)	0.558	8
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.556	3
UniProt:Q16637 SMN1	2	SMN1 [cytosol] (R-HSA-191839) SMN1 [nucleoplasm] (R-HSA-191892)	0.556	3
UniProt:Q9UPE1 SRPK3			0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.527	6
UniProt:Q53F19 NCBP3			0.527	4
UniProt:Q96SB4 SRPK1	2	SRPK1 [cytosol] (R-HSA-9729349) SRPK1 [nucleoplasm] (R-HSA-9821984)	0.527	2
UniProt:Q9UKK6 NXT1	2	NXT1 [cytosol] (R-HSA-8849122) NXT1 [nucleoplasm] (R-HSA-8849151)	0.499	4
UniProt:Q13769 THOC5	3	THOC5 [nucleoplasm] (R-HSA-8849111) THOC5 [cytosol] (R-HSA-9682751) p-Y-THOC5 [cytosol] (R-HSA-9682738)	0.462	4
UniProt:Q96FV9 THOC1	1	THOC1 [nucleoplasm] (R-HSA-8849130)	0.462	4

Cite Us!