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What is Reactome ?
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SPTBN1 [cytosol]
Stable Identifier
R-HSA-420048
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Spectrin beta chain, brain 1, SPTB2_HUMAN
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Nephrin family interactions (Homo sapiens)
Interaction of nephrin with adherens junction-associated proteins (Homo sapiens)
Nephrin dimer:adherins junction-associated proteins [plasma membrane] (Homo sapiens)
adherens junction-associated proteins [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
adherens junction-associated proteins [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Interaction between L1 and Ankyrins (Homo sapiens)
Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin [plasma membrane] (Homo sapiens)
SPTA:SPTB:F-actin [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin:KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin [plasma membrane] (Homo sapiens)
SPTA:SPTB:F-actin [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
L1 linked to actin cytoskeleton by ankyrin (Homo sapiens)
L1 dimer:Ankyrin:Spectrin:F-actin [plasma membrane] (Homo sapiens)
SPTA:SPTB:F-actin [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
SPTA:SPTB:F-actin [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
NCAM signaling for neurite out-growth (Homo sapiens)
Autophosphorylation of NCAM1 bound Fyn (Homo sapiens)
Fyn:NCAM1:RPTP-alpha [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Dephosphorylation of NCAM1 bound pFyn (Homo sapiens)
Fyn:NCAM1:RPTP-alpha [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Homo sapiens)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Phosphorylation of FAK by Src kinase (Homo sapiens)
Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
pFAK (391) bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Recruitment of FAK to NCAM1:Fyn in lipid rafts (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
pFAK (391) bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Recruitment of Grb2 to pFAK:NCAM1 (Homo sapiens)
Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
SOS binds Grb2 bound to pFAK:NCAM1 (Homo sapiens)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Sensory Perception (Homo sapiens)
Sensory processing of sound (Homo sapiens)
Sensory processing of sound by inner hair cells of the cochlea (Homo sapiens)
Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell (Homo sapiens)
MET channel:Tip link:USH1C:USH1G:MYO7A:cytoskeleton (IHC) [plasma membrane] (Homo sapiens)
Inner hair cell stereocilium cytoskeleton [cytosol] (Homo sapiens)
Stereocilium cuticular plate [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Stereocilium rootlet [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Sensory processing of sound by outer hair cells of the cochlea (Homo sapiens)
Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell (Homo sapiens)
MET channel:Tip link:USH1C:USH1G:MYO7A:cytoskeleton (OHC) [plasma membrane] (Homo sapiens)
Outer hair cell stereocilium cytoskeleton [cytosol] (Homo sapiens)
Stereocilium cuticular plate [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Stereocilium rootlet [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOU GTPase cycle (Homo sapiens)
RHOU binds effectors at the plasma membrane (Homo sapiens)
RHOU effectors [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
RHOU:GTP:RHOU effectors [plasma membrane] (Homo sapiens)
RHOU effectors [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
RHOV GTPase cycle (Homo sapiens)
RHOV binds effectors at the plasma membrane (Homo sapiens)
RHOV effectors [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
RHOV:GTP:RHOV effectors [plasma membrane] (Homo sapiens)
RHOV effectors [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Spectrin tetramer [cytosol] (Homo sapiens)
SPTA:SPTB [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
SPTBN1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01082 SPTBN1
Gene Names
SPTBN1, SPTB2
Chain
initiator methionine:, chain:2-2364
Reference Genes
BioGPS Gene:6711 SPTBN1
COSMIC (genes):SPTBN1 SPTBN1
CTD Gene:6711 SPTBN1
dbSNP Gene:6711 SPTBN1
ENSEMBL:ENSG00000115306 SPTBN1
ENSEMBL_homo_sapiens_GENE:ENSG00000115306.17 SPTBN1
HGNC:11275 SPTBN1
KEGG Gene (Homo sapiens):6711 SPTBN1
Monarch:6711 SPTBN1
NCBI Gene:6711 SPTBN1
OMIM:182790 SPTBN1
UCSC:Q01082 SPTBN1
Reference Transcript
RefSeq:XM_017004781.1 SPTBN1
RefSeq:XM_017004779.1 SPTBN1
RefSeq:XM_017004780.1 SPTBN1
RefSeq:XM_006712087.2 SPTBN1
RefSeq:XM_005264517.2 SPTBN1
RefSeq:NM_003128.2 SPTBN1
RefSeq:NM_178313.2 SPTBN1
Other Identifiers
11716418_a_at
11716419_at
11716420_s_at
11716421_at
11716422_x_at
11716423_a_at
11722689_a_at
11722690_at
11758629_s_at
16880122
200671_PM_s_at
200671_s_at
200672_PM_x_at
200672_x_at
212071_PM_s_at
212071_s_at
215918_PM_s_at
215918_s_at
226342_PM_at
226342_at
230540_PM_at
230540_at
242220_PM_at
242220_at
2482506
2482507
2482511
2482512
2482527
2482528
2482529
2482530
2482542
2482547
2482549
2482550
2482551
2482554
2482555
2482556
2482557
2482558
2482559
2482560
2482563
2482564
2482566
2482568
2482573
2482577
2482578
2482581
2482582
2482584
2482585
2482586
2482587
2482588
2482589
2482590
2482592
2482593
2482594
2482597
2482598
2482600
2482601
2482602
2482603
2482604
2482605
2482606
2482607
2482608
2482609
2482610
2482611
2482612
2482613
2482614
2482615
2482616
2482618
2482620
2482621
2482622
2482623
2482624
2482625
39452_s_at
39556_at
45202_at
52616_at
53241_at
58823_s_at
6711
73102_at
74748_s_at
8041995
81959_at
90584_at
A_14_P121454
A_23_P102523
A_23_P339095
A_33_P3258467
A_33_P3258472
GE55162
GE58172
GE84893
GE877747
GO:0000278
GO:0000281
GO:0000910
GO:0003723
GO:0003779
GO:0005198
GO:0005200
GO:0005515
GO:0005516
GO:0005543
GO:0005576
GO:0005615
GO:0005634
GO:0005730
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0007009
GO:0007010
GO:0007417
GO:0008091
GO:0008092
GO:0008289
GO:0014069
GO:0014731
GO:0016020
GO:0016192
GO:0021556
GO:0023052
GO:0030036
GO:0030054
GO:0030506
GO:0030673
GO:0030863
GO:0030864
GO:0031430
GO:0032437
GO:0032743
GO:0032991
GO:0042995
GO:0043001
GO:0043226
GO:0044877
GO:0045296
GO:0048856
GO:0051015
GO:0051020
GO:0051693
GO:0060390
GO:0061024
GO:0065003
GO:0070062
GO:0071709
GO:0072659
GO:0098794
GO:0098978
GO:1903076
GO:1903078
HMNXSV003013564
HMNXSV003023445
Hs.107164.0.S1_3p_a_at
Hs.107164.4.S1_3p_a_at
Hs.107164.4.S1_3p_at
Hs.155033.0.A1_3p_at
Hs.236443.0.S1_3p_at
Hs.27286.0.A1_3p_at
Hs.324648.0.S1_3p_at
ILMN_1661335
ILMN_1690708
ILMN_1714228
M96803_at
PH_hs_0023033
TC02000315.hg
TC02003238.hg
TC02003240.hg
g4507194_3p_s_at
Participates
as a candidate of
RHOV effectors [cytosol] (Homo sapiens)
RHOU effectors [cytosol] (Homo sapiens)
as a component of
Stereocilium rootlet [cytosol] (Homo sapiens)
Stereocilium cuticular plate [cytosol] (Homo sapiens)
as a member of
adherens junction-associated proteins [cytosol] (Homo sapiens)
Spectrin beta chain [cytosol] (Homo sapiens)
Other forms of this molecule
SPTBN1(2-159)-FLT3(570-993) fusion [cytosol]
SPTBN1(2-159)-p-6Y-FLT3(570-993) fusion [cytosol]
Inferred To
unc-70 [cytosol]
(Caenorhabditis elegans)
beta-Spec [cytosol]
(Drosophila melanogaster)
ain1 [cytosol]
(Schizosaccharomyces pombe)
Homologues of SPTBN1 [cytosol]
(Dictyostelium discoideum)
SPTBN1 [cytosol]
(Bos taurus)
SPTBN1 [cytosol]
(Canis familiaris)
SPTBN1 [cytosol]
(Dictyostelium discoideum)
SPTBN1 [cytosol]
(Gallus gallus)
SPTBN1 [cytosol]
(Sus scrofa)
abpD [cytosol]
(Dictyostelium discoideum)
Sptbn1 [cytosol]
(Mus musculus)
Sptbn1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_003119.2
,
XP_016860268.1
,
XP_006712150.1
,
NP_842565.2
,
XP_016860270.1
,
XP_005264574.1
,
XP_016860269.1
OpenTargets
ENSG00000115306
HPA
ENSG00000115306-SPTBN1
GeneCards
Q01082
Ensembl
ENSP00000349259
,
ENSP00000334156
,
ENST00000356805
,
ENST00000333896
,
ENSG00000115306
PRO
Q01082
Pharos - Targets
Q01082
HMDB Protein
HMDBP08005
PDB
1AA2
,
3EDV
,
1BKR
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13813 SPTAN1
6
SPTAN1 [cytosol]
(R-HSA-201601)
SPTAN1(1-1185) [cytosol]
(R-HSA-202944)
SPTAN1(1186-2472) [cytosol]
(R-HSA-202964)
SPTAN1 [specific granule lumen]
(R-HSA-6799533)
SPTAN1 [extracellular region]
(R-HSA-6806322)
SPTAN1 [tertiary granule lumen]
(R-HSA-6800874)
0.609
8
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.547
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
12
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