Reactome | CCT4 [cytosol]

CCT4 [cytosol]

Stable Identifier

R-HSA-390458

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

T-complex protein 1 subunit delta (TCP-1-delta)

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Cargo trafficking to the periciliary membrane (Homo sapiens)
    - BBSome-mediated cargo-targeting to cilium (Homo sapiens)
      - Formation of the BBSome (Homo sapiens)
        
        BBS/CCT complex [cytosol] (Homo sapiens)
        
        CCT4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P50991 CCT4

Gene Names

CCT4, CCTD, SRB

Chain

initiator methionine:1, chain:2-539

Reference Genes

BioGPS Gene:10575 CCT4

COSMIC (genes):CCT4 CCT4

CTD Gene:10575 CCT4

dbSNP Gene:10575 CCT4

ENSEMBL:ENSG00000115484 CCT4

HGNC:1617 CCT4

KEGG Gene (Homo sapiens):10575 CCT4

Monarch:10575 CCT4

NCBI Gene:10575 CCT4

OMIM:605142 CCT4

UCSC:P50991 CCT4

Reference Transcript

Other Identifiers

0002690025

10575

11732127_a_at

11732128_s_at

11747041_x_at

11749821_x_at

16898175

200877_at

2555635

2555636

2555637

2555638

2555639

2555640

2555642

2555646

2555647

2555648

2555650

2555652

2555654

2555655

2555656

2555657

2555660

2555664

2555666

2555672

2555673

2555674

2555675

2555676

32594_at

8052562

A_23_P102420

A_33_P3229397

GE81635

GE88842

GO:0000003

GO:0000166

GO:0002199

GO:0003674

GO:0003723

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005832

GO:0005856

GO:0005874

GO:0006259

GO:0006457

GO:0006810

GO:0007339

GO:0008150

GO:0009058

GO:0016887

GO:0031410

GO:0032212

GO:0032991

GO:0034641

GO:0042470

GO:0042592

GO:0042995

GO:0043167

GO:0043226

GO:0044183

GO:0044297

GO:0050821

GO:0051082

GO:0051276

GO:0051973

GO:0070062

GO:0090666

GO:1901998

GO:1904851

GO:1904871

GO:1904874

HMNXSV003020720

ILMN_1776073

PH_hs_0018126

TC02001895.hg

U38846_at

g5453604_3p_s_at

Participates

as a component of

Inferred To

tcp-1 delta [cytosol] (Gallus gallus)

cct4 [cytosol] (Danio rerio)

cct4 [cytosol] (Dictyostelium discoideum)

cct4 [cytosol] (Schizosaccharomyces pombe)

CCT4 [cytosol] (Canis familiaris)

CCT4 [cytosol] (Drosophila melanogaster)

CCT4 [cytosol] (Plasmodium falciparum)

CCT4 [cytosol] (Saccharomyces cerevisiae)

CCT4 [cytosol] (Sus scrofa)

cct-4 [cytosol] (Caenorhabditis elegans)

Cct4 [cytosol] (Mus musculus)

Cct4 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_006421.2, NP_001243650.1

OpenTargets

ENSG00000115484

HPA

ENSG00000115484-CCT4

GeneCards

P50991

Ensembl

ENST00000544079, ENSP00000443061, ENST00000394440, ENSG00000115484, ENSP00000377958

PRO

P50991

Pharos - Targets

P50991

GlyGen

P50991

PDB

6NRA, 6NRC, 6NR9, 6QB8, 6NR8, 6NRB, 6NRD

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	SUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030) HDAC1 [nucleoplasm] (R-HSA-205021)	0.643	4
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.643	3
UniProt:P78380 OLR1	3	OLR1 [tertiary granule membrane] (R-HSA-6800883) OLR1 [specific granule membrane] (R-HSA-6799518) OLR1 [plasma membrane] (R-HSA-203139)	0.591	3
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.564	2
UniProt:O43815 STRN	5	STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) STRN [cytosol] (R-HSA-9037081) p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2
UniProt:P52333 JAK3	6	p-Y904,939-JAK3 [plasma membrane] (R-HSA-8985978) p-Y980 JAK3 [cytosol] (R-HSA-9701438) JAK3 [endosome] (R-HSA-8983184) p-Y-JAK3 [cytosol] (R-HSA-9006854) p-JAK3 [cytosol] (R-HSA-8982856) JAK3 [cytosol] (R-HSA-451893)	0.527	2
UniProt:Q9BUR4 WRAP53	2	Unfolded WRAP53 [cytosol] (R-HSA-6813830) WRAP53 [nucleoplasm] (R-HSA-418386)	0.527	2
UniProt:Q00535 CDK5	4	p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15-CDK5 [cytosol] (R-HSA-399809) CDK5 [cytosol] (R-HSA-180064)	0.527	2
UniProt:Q13882 PTK6	5	p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y342-PTK6 [cytosol] (R-HSA-8848007) PTK6 [cytosol] (R-HSA-8848000) p-Y351-PTK6 [cytosol] (R-HSA-8857570)	0.527	3