Reactome | CCT4 [cytosol]

CCT4 [cytosol]

Stable Identifier

R-HSA-390458

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

T-complex protein 1 subunit delta (TCP-1-delta)

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Cargo trafficking to the periciliary membrane (Homo sapiens)
    - BBSome-mediated cargo-targeting to cilium (Homo sapiens)
      - Formation of the BBSome (Homo sapiens)
        
        BBS/CCT complex [cytosol] (Homo sapiens)
        
        CCT4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P50991 CCT4

Gene Names

CCT4, CCTD, SRB

Chain

initiator methionine:1, chain:2-539

Reference Genes

BioGPS Gene:10575 CCT4

COSMIC (genes):CCT4 CCT4

CTD Gene:10575 CCT4

dbSNP Gene:10575 CCT4

ENSEMBL:ENSG00000115484 CCT4

HGNC:1617 CCT4

KEGG Gene (Homo sapiens):10575 CCT4

Monarch:10575 CCT4

NCBI Gene:10575 CCT4

OMIM:605142 CCT4

UCSC:P50991 CCT4

Reference Transcript

Other Identifiers

0002690025

10575

11732127_a_at

11732128_s_at

11747041_x_at

11749821_x_at

16898175

200877_PM_at

200877_at

2555635

2555636

2555637

2555638

2555639

2555640

2555642

2555646

2555647

2555648

2555650

2555652

2555654

2555655

2555656

2555657

2555660

2555664

2555666

2555672

2555673

2555674

2555675

2555676

32594_at

8052562

A_23_P102420

A_33_P3229397

GE81635

GE88842

GO:0000003

GO:0000166

GO:0002199

GO:0003674

GO:0003723

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005832

GO:0005856

GO:0005874

GO:0006259

GO:0006457

GO:0006810

GO:0007339

GO:0008150

GO:0009058

GO:0016887

GO:0031410

GO:0032212

GO:0032991

GO:0034641

GO:0042470

GO:0042995

GO:0043167

GO:0043226

GO:0044183

GO:0044297

GO:0050821

GO:0051082

GO:0051276

GO:0051973

GO:0061077

GO:0070062

GO:0090666

GO:0140657

GO:1901998

GO:1904851

GO:1904871

GO:1904874

HMNXSV003020720

ILMN_1776073

PH_hs_0018126

TC02001895.hg

U38846_at

g5453604_3p_s_at

Participates

as a component of

Inferred To

tcp-1 delta [cytosol] (Gallus gallus)

cct4 [cytosol] (Danio rerio)

cct4 [cytosol] (Dictyostelium discoideum)

cct4 [cytosol] (Schizosaccharomyces pombe)

cct4 [cytosol] (Xenopus tropicalis)

CCT4 [cytosol] (Bos taurus)

CCT4 [cytosol] (Canis familiaris)

CCT4 [cytosol] (Drosophila melanogaster)

CCT4 [cytosol] (Plasmodium falciparum)

CCT4 [cytosol] (Saccharomyces cerevisiae)

CCT4 [cytosol] (Sus scrofa)

cct-4 [cytosol] (Caenorhabditis elegans)

Cct4 [cytosol] (Mus musculus)

Cct4 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001243650.1, NP_006421.2

OpenTargets

ENSG00000115484

GeneCards

P50991

HPA

ENSG00000115484-CCT4

Ensembl

ENST00000394440, ENSP00000443061, ENSP00000377958, ENST00000544079, ENSG00000115484

PRO

P50991

Pharos - Targets

P50991

PDB

7LUM, 6QB8, 6NRB, 6NR8, 7LUP, 6NRD, 6NR9, 6NRC, 6NRA

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.725	4
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) p-Y15-CDK5 [cytosol] (R-HSA-399809) CDK5 [cytosol] (R-HSA-180064)	0.643	3
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.643	4
UniProt:P78380 OLR1	3	OLR1 [tertiary granule membrane] (R-HSA-6800883) OLR1 [plasma membrane] (R-HSA-203139) OLR1 [specific granule membrane] (R-HSA-6799518)	0.591	3
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.564	2
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.527	2
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2
UniProt:P06493 CDK1	10	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	8
UniProt:Q13882 PTK6	5	p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y351-PTK6 [cytosol] (R-HSA-8857570) p-Y342-PTK6 [cytosol] (R-HSA-8848007) PTK6 [cytosol] (R-HSA-8848000)	0.527	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.527	2
UniProt:P52333 JAK3	6	p-Y980 JAK3 [cytosol] (R-HSA-9701438) JAK3 [endosome] (R-HSA-8983184) p-JAK3 [cytosol] (R-HSA-8982856) p-Y-JAK3 [cytosol] (R-HSA-9006854) p-Y904,939-JAK3 [plasma membrane] (R-HSA-8985978) JAK3 [cytosol] (R-HSA-451893)	0.527	2

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