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EPS8 [cytosol]
Stable Identifier
R-HSA-9662382
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Epidermal growth factor receptor kinase substrate 8, EPS8_HUMAN
Locations in the PathwayBrowser
Expand all
Sensory Perception (Homo sapiens)
Sensory processing of sound (Homo sapiens)
Sensory processing of sound by inner hair cells of the cochlea (Homo sapiens)
Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell (Homo sapiens)
MET channel:Tip link:USH1C:USH1G:MYO7A:cytoskeleton (IHC) [plasma membrane] (Homo sapiens)
Inner hair cell stereocilium cytoskeleton [cytosol] (Homo sapiens)
Inner hair cell stereocilium tip [cytosol] (Homo sapiens)
EPS8 [cytosol] (Homo sapiens)
Sensory processing of sound by outer hair cells of the cochlea (Homo sapiens)
Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell (Homo sapiens)
MET channel:Tip link:USH1C:USH1G:MYO7A:cytoskeleton (OHC) [plasma membrane] (Homo sapiens)
Outer hair cell stereocilium cytoskeleton [cytosol] (Homo sapiens)
Outer hair cell stereocilium tip [cytosol] (Homo sapiens)
EPS8 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q12929 EPS8
Gene Names
EPS8
Chain
chain:1-822
Reference Genes
BioGPS Gene:2059 EPS8
COSMIC (genes):EPS8 EPS8
CTD Gene:2059 EPS8
dbSNP Gene:2059 EPS8
ENSEMBL:ENSG00000151491 EPS8
ENSEMBL_homo_sapiens_GENE:ENSG00000151491.14 EPS8
HGNC:3420 EPS8
KEGG Gene (Homo sapiens):2059 EPS8
Monarch:2059 EPS8
NCBI Gene:2059 EPS8
OMIM:600206 EPS8
UCSC:Q12929 EPS8
Reference Transcript
RefSeq:NM_004447.5 EPS8
Other Identifiers
11717440_a_at
11717441_a_at
11748091_a_at
1467_at
16761877
16761919
202609_PM_at
202609_at
2059
3445909
3445910
3445911
3445912
3445914
3445915
3445918
3445919
3445923
3445924
3445925
3445926
3445927
3445931
3445932
3445933
3445934
3445935
3445938
3445939
3445940
3445941
3445942
3445943
3445946
3445947
3445953
3445954
3445964
3445971
3445973
3445974
3445976
7961546
A_23_P136347
GE58932
GO:0000278
GO:0002376
GO:0003779
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005886
GO:0005903
GO:0005938
GO:0007010
GO:0007266
GO:0008092
GO:0008344
GO:0008360
GO:0010458
GO:0014069
GO:0016020
GO:0016601
GO:0017146
GO:0023052
GO:0030036
GO:0030426
GO:0030832
GO:0031267
GO:0031982
GO:0032420
GO:0032421
GO:0032426
GO:0032587
GO:0035023
GO:0036336
GO:0042995
GO:0043005
GO:0043226
GO:0045202
GO:0048149
GO:0048856
GO:0048870
GO:0051016
GO:0051017
GO:0051764
GO:0065003
GO:0070062
GO:0070358
GO:0098978
GO:0099072
GO:0140014
GO:1900029
GO:1990830
HMNXSV003007413
HMNXSV003026518
ILMN_1651699
PH_hs_0000282
TC12001282.hg
TC12001284.hg
TC12002780.hg
U12535_at
g4758295_3p_at
Participates
as a component of
Inner hair cell stereocilium tip [cytosol] (Homo sapiens)
Outer hair cell stereocilium tip [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_004438.3
OpenTargets
ENSG00000151491
HPA
ENSG00000151491-EPS8
GeneCards
Q12929
Ensembl
ENST00000646828
,
ENST00000543612
,
ENSG00000151491
,
ENSP00000496516
,
ENSP00000495722
,
ENST00000540613
,
ENSP00000495824
,
ENSP00000442388
,
ENST00000543523
,
ENST00000647087
,
ENST00000642278
,
ENST00000647224
,
ENST00000644374
,
ENST00000542903
,
ENST00000645775
,
ENSP00000441888
,
ENSP00000441867
,
ENSP00000494842
,
ENSP00000281172
,
ENST00000646918
,
ENSP00000496406
,
ENST00000281172
,
ENSP00000494689
,
ENSP00000437806
,
ENSP00000495956
PRO
Q12929
Pharos - Targets
Q12929
Orphanet
22881
PDB
7TZK
,
2E8M
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UQB8 BAIAP2
1
BAIAP2 [cytosol]
(R-HSA-442574)
0.891
12
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.713
4
UniProt:Q13895 BYSL
2
BYSL [nucleoplasm]
(R-HSA-6791526)
BYSL [cytosol]
(R-HSA-6791518)
0.556
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.556
3
UniProt:P07910 HNRNPC
3
HNRNPC [cytosol]
(R-HSA-9715136)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [nucleoplasm]
(R-HSA-71933)
0.556
3
UniProt:O14936 CASK
1
CASK [cytosol]
(R-HSA-373631)
0.524
3
UniProt:P49419 ALDH7A1
1
ALDH7A1 [mitochondrial matrix]
(R-HSA-508562)
0.508
2
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.488
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
4
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