Reactome | PPA1 [cytosol]

PPA1 [cytosol]

Stable Identifier

R-HSA-71725

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

pyrophosphatase (inorganic) 1, Inorganic pyrophosphatase , Pyrophosphate phospho-hydrolase

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q15181 PPA1

Gene Names

PPA1, IOPPP, PP

Chain

initiator methionine:1, chain:2-289

Reference Genes

BioGPS Gene:5464 PPA1

COSMIC (genes):PPA1 PPA1

CTD Gene:5464 PPA1

dbSNP Gene:5464 PPA1

ENSEMBL:ENSG00000180817 PPA1

ENSEMBL:ENSG00000180817.12 PPA1

HGNC:9226 PPA1

KEGG Gene (Homo sapiens):5464 PPA1

Monarch:5464 PPA1

NCBI Gene:5464 PPA1

OMIM:179030 PPA1

Reference Transcript

RefSeq:NM_021129.3 PPA1

Other Identifiers

11715684_a_at

16715133

217848_PM_s_at

217848_s_at

2841282

3293281

3293282

3293285

3293288

3293289

3293291

3293293

3293294

3293295

3293298

3293304

3293305

3293306

5464

59718_at

64333_s_at

7934133

A_23_P161338

A_33_P3271241

GE80789

GO:0000287

GO:0003824

GO:0004427

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0006796

GO:0016462

GO:0016787

GO:0043226

GO:0046872

GO:0070062

HMNXSV003033189

ILMN_1805827

PH_hs_0029963

TC10001362.hg

g11056043_3p_a_at

Participates

as a component of

PPA1 dimer [cytosol] (Homo sapiens)

Inferred To

Homologues of PPA1 [cytosol] (Plasmodium falciparum)

PPA1 [cytosol] (Bos taurus)

PPA1 [cytosol] (Caenorhabditis elegans)

PPA1 [cytosol] (Canis familiaris)

PPA1 [cytosol] (Danio rerio)

PPA1 [cytosol] (Dictyostelium discoideum)

PPA1 [cytosol] (Drosophila melanogaster)

PPA1 [cytosol] (Gallus gallus)

PPA1 [cytosol] (Mus musculus)

PPA1 [cytosol] (Plasmodium falciparum)

PPA1 [cytosol] (Saccharomyces cerevisiae)

PPA1 [cytosol] (Schizosaccharomyces pombe)

PPA1 [cytosol] (Sus scrofa)

Ppa1 [cytosol] (Rattus norvegicus)

ppa2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_066952.1

OpenTargets

ENSG00000180817

GeneCards

Q15181

HPA

ENSG00000180817-PPA1

Ensembl

ENSG00000180817, ENSP00000362329, ENST00000373232

PRO

Q15181

Pharos - Targets

Q15181

HMDB Protein

HMDBP01071

PDB

6C45, 7BTN, 7CMO

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	8

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