Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PPA1 [cytosol]
Stable Identifier
R-HSA-71725
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
pyrophosphatase (inorganic) 1, Inorganic pyrophosphatase , Pyrophosphate phospho-hydrolase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Pyrophosphate hydrolysis (Homo sapiens)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Homo sapiens)
PPA1 dimer [cytosol] (Homo sapiens)
PPA1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
tRNA Aminoacylation (Homo sapiens)
Cytosolic tRNA aminoacylation (Homo sapiens)
PPA1 hydrolyzes pyrophosphate to orthophosphate (Homo sapiens)
PPA1 dimer [cytosol] (Homo sapiens)
PPA1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15181 PPA1
Gene Names
PPA1, IOPPP, PP
Chain
initiator methionine:, chain:2-289
Reference Genes
BioGPS Gene:5464 PPA1
COSMIC (genes):PPA1 PPA1
CTD Gene:5464 PPA1
dbSNP Gene:5464 PPA1
ENSEMBL:ENSG00000180817 PPA1
ENSEMBL_homo_sapiens_GENE:ENSG00000180817.12 PPA1
HGNC:9226 PPA1
KEGG Gene (Homo sapiens):5464 PPA1
Monarch:5464 PPA1
NCBI Gene:5464 PPA1
OMIM:179030 PPA1
Reference Transcript
RefSeq:NM_021129.3 PPA1
Other Identifiers
11715684_a_at
16715133
217848_PM_s_at
217848_s_at
2841282
3293281
3293282
3293285
3293288
3293289
3293291
3293293
3293294
3293295
3293298
3293304
3293305
3293306
5464
59718_at
64333_s_at
7934133
A_23_P161338
A_33_P3271241
GE80789
GO:0000287
GO:0003824
GO:0004427
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0006796
GO:0016462
GO:0016787
GO:0043226
GO:0046872
GO:0070062
HMNXSV003033189
ILMN_1805827
PH_hs_0029963
TC10001362.hg
g11056043_3p_a_at
Participates
as a component of
PPA1 dimer [cytosol] (Homo sapiens)
Inferred To
Homologues of PPA1 [cytosol]
(Plasmodium falciparum)
PPA1 [cytosol]
(Bos taurus)
PPA1 [cytosol]
(Caenorhabditis elegans)
PPA1 [cytosol]
(Canis familiaris)
PPA1 [cytosol]
(Dictyostelium discoideum)
PPA1 [cytosol]
(Drosophila melanogaster)
PPA1 [cytosol]
(Gallus gallus)
PPA1 [cytosol]
(Mus musculus)
PPA1 [cytosol]
(Plasmodium falciparum)
PPA1 [cytosol]
(Saccharomyces cerevisiae)
PPA1 [cytosol]
(Schizosaccharomyces pombe)
PPA1 [cytosol]
(Sus scrofa)
Ppa1 [cytosol]
(Rattus norvegicus)
ppa2 [cytosol]
(Xenopus tropicalis)
ppa1b [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_066952.1
OpenTargets
ENSG00000180817
GeneCards
Q15181
HPA
ENSG00000180817-PPA1
Ensembl
ENST00000373232
,
ENSP00000362329
,
ENSG00000180817
PRO
Q15181
Pharos - Targets
Q15181
HMDB Protein
HMDBP01071
PDB
6C45
,
7CMO
,
8J7Q
,
7BTN
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
11
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text