Reactome | YME1L1 [mitochondrial inner membrane]

YME1L1 [mitochondrial inner membrane]

Stable Identifier

R-HSA-8949648

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

ATP-dependent zinc metalloprotease YME1L1 ecNumber3.4.24.-/ecNumber, YMEL1_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to mitochondrial stress (Homo sapiens)
    - OMA1 hydrolyzes YME1L1 (Homo sapiens)
      - YME1L1:Zn2+ hexamer [mitochondrial inner membrane] (Homo sapiens)
        
        YME1L1:Zn2+ [mitochondrial inner membrane] (Homo sapiens)
        
        YME1L1 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96TA2 YME1L1

Gene Names

YME1L1, FTSH1, YME1L, UNQ1868/PRO4304

Chain

chain:1-773

Reference Genes

BioGPS Gene:10730 YME1L1

COSMIC (genes):YME1L1 YME1L1

CTD Gene:10730 YME1L1

dbSNP Gene:10730 YME1L1

ENSEMBL:ENSG00000136758 YME1L1

HGNC:12843 YME1L1

KEGG:hsa:10730 YME1L1

Monarch:10730 YME1L1

NCBI Gene:10730 YME1L1

OMIM:607472 YME1L1

UCSC:Q96TA2 YME1L1

Reference Transcript

Other Identifiers

10730

11720453_x_at

11720454_a_at

11720495_x_at

11759916_at

16712703

201351_PM_s_at

201351_s_at

201352_PM_at

201352_at

216304_PM_x_at

216304_x_at

232216_PM_at

232216_at

3282212

3282214

3282215

3282216

3282217

3282218

3282219

3282220

3282221

3282222

3282223

3282224

3282225

3282226

3282227

3282228

3282230

3282231

3282233

3282234

3282235

3282236

3282240

3282243

3282246

3282247

3282248

3282249

3282252

3282253

3282254

3282255

3282256

3282257

3282259

3282260

3282261

3282262

3841429

3951430

40988_at

51843_f_at

67175_at

70682_at

7932678

A_23_P104201

A_24_P167052

GE62922

GO:0003824

GO:0004176

GO:0004222

GO:0005515

GO:0005524

GO:0005739

GO:0005743

GO:0006508

GO:0006515

GO:0007005

GO:0008237

GO:0008283

GO:0009267

GO:0010636

GO:0016020

GO:0016604

GO:0016787

GO:0016887

GO:0030163

GO:0034214

GO:0034982

GO:0035694

GO:0043066

GO:0043226

GO:0046872

GO:0051604

GO:0065003

GO:0097150

GO:0140096

GO:0140657

GO:2000035

HMNXSV003021524

Hs.287544.0.S1_3p_at

ILMN_1734316

ILMN_2339825

PH_hs_0028457

TC10001126.hg

g4454687_3p_a_at

g7657688_3p_at

Participates

as a component of

YME1L1:Zn2+ [mitochondrial inner membrane] (Homo sapiens)

Inferred To

yme1l1 [mitochondrial inner membrane] (Xenopus tropicalis)

YME1L1 [mitochondrial inner membrane] (Bos taurus)

YME1L1 [mitochondrial inner membrane] (Canis familiaris)

YME1L1 [mitochondrial inner membrane] (Dictyostelium discoideum)

YME1L1 [mitochondrial inner membrane] (Gallus gallus)

YME1L1 [mitochondrial inner membrane] (Mus musculus)

YME1L1 [mitochondrial inner membrane] (Plasmodium falciparum)

YME1L1 [mitochondrial inner membrane] (Rattus norvegicus)

YME1L1 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

YME1L1 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

Cross References

ENSEMBL

ENST00000326799, ENSP00000318480, ENST00000376016, ENSP00000365184

OpenTargets

ENSG00000136758

HPA

ENSG00000136758-YME1L1

PRO

Q96TA2

Pharos - Targets

Q96TA2

GlyGen

Q96TA2

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	9