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DYNLL1 [ciliary tip]
Stable Identifier
R-HSA-5625335
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ciliary tip
Icon
Locations in the PathwayBrowser
Expand all
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Intraflagellar transport (Homo sapiens)
Anterograde IFT (Homo sapiens)
anterograde IFT trains [ciliary tip] (Homo sapiens)
dynein-2 [ciliary tip] (Homo sapiens)
dynein-2 light chains [ciliary tip] (Homo sapiens)
DYNLL1 [ciliary tip] (Homo sapiens)
Assembly of the retrograde IFT train (Homo sapiens)
active dynein-2 motors [ciliary tip] (Homo sapiens)
dynein-2 [ciliary tip] (Homo sapiens)
dynein-2 light chains [ciliary tip] (Homo sapiens)
DYNLL1 [ciliary tip] (Homo sapiens)
retrograde IFT trains [ciliary tip] (Homo sapiens)
active dynein-2 motors [ciliary tip] (Homo sapiens)
dynein-2 [ciliary tip] (Homo sapiens)
dynein-2 light chains [ciliary tip] (Homo sapiens)
DYNLL1 [ciliary tip] (Homo sapiens)
Retrograde IFT (Homo sapiens)
retrograde IFT trains [ciliary tip] (Homo sapiens)
active dynein-2 motors [ciliary tip] (Homo sapiens)
dynein-2 [ciliary tip] (Homo sapiens)
dynein-2 light chains [ciliary tip] (Homo sapiens)
DYNLL1 [ciliary tip] (Homo sapiens)
The anterograde IFT train dissociates (Homo sapiens)
anterograde IFT trains [ciliary tip] (Homo sapiens)
dynein-2 [ciliary tip] (Homo sapiens)
dynein-2 light chains [ciliary tip] (Homo sapiens)
DYNLL1 [ciliary tip] (Homo sapiens)
dynein-2 [ciliary tip] (Homo sapiens)
dynein-2 light chains [ciliary tip] (Homo sapiens)
DYNLL1 [ciliary tip] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63167 DYNLL1
Gene Names
DYNLL1, DLC1, DNCL1, DNCLC1, HDLC1
Chain
chain:1-89
Reference Genes
BioGPS Gene:8655 DYNLL1
COSMIC (genes):DYNLL1 DYNLL1
CTD Gene:8655 DYNLL1
dbSNP Gene:8655 DYNLL1
ENSEMBL:ENSG00000088986 DYNLL1
ENSEMBL_homo_sapiens_GENE:ENSG00000088986.11 DYNLL1
HGNC:15476 DYNLL1
KEGG Gene (Homo sapiens):8655 DYNLL1
Monarch:8655 DYNLL1
NCBI Gene:8655 DYNLL1
OMIM:601562 DYNLL1
Reference Transcript
RefSeq:NM_003746.2 DYNLL1
RefSeq:NM_001037494.1 DYNLL1
RefSeq:NM_001037495.1 DYNLL1
Other Identifiers
11753833_a_at
200703_PM_at
200703_at
3059785
3434394
3434396
3434398
3434402
3434403
3434404
3434407
3434408
3434409
3434410
34891_at
3574114
3574116
7959164
7980535
8655
A_23_P65031
A_24_P124672
GE61176
GO:0000776
GO:0004857
GO:0005515
GO:0005634
GO:0005694
GO:0005737
GO:0005739
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005868
GO:0005874
GO:0005875
GO:0005886
GO:0005929
GO:0006915
GO:0007005
GO:0007017
GO:0007018
GO:0007286
GO:0008180
GO:0012501
GO:0015630
GO:0016020
GO:0019899
GO:0019904
GO:0021762
GO:0022414
GO:0023052
GO:0030141
GO:0030154
GO:0030235
GO:0030286
GO:0031410
GO:0035721
GO:0035774
GO:0036487
GO:0042326
GO:0042802
GO:0043226
GO:0044458
GO:0044782
GO:0044877
GO:0045019
GO:0045505
GO:0048856
GO:0051881
GO:0070821
GO:0072686
GO:0097110
GO:0097542
GO:0098772
GO:0101003
GO:0160040
GO:1902857
GO:1904115
HMNXSV003054414
ILMN_2300186
PH_hs_0035324
U32944_at
g4505812_3p_at
Participates
as a member of
dynein-2 light chains [ciliary tip] (Homo sapiens)
Other forms of this molecule
DYNLL1 [cilium]
DYNLL1 [ficolin-1-rich granule membrane]
DYNLL1 [tertiary granule membrane]
DYNLL1 [plasma membrane]
DYNLL1 [cytosol]
Inferred To
dlc-6 [ciliary tip]
(Caenorhabditis elegans)
dlc-3 [ciliary tip]
(Caenorhabditis elegans)
dlc-1 [ciliary tip]
(Caenorhabditis elegans)
dlc-2 [ciliary tip]
(Caenorhabditis elegans)
dlc-5 [ciliary tip]
(Caenorhabditis elegans)
Dynll1 [ciliary tip]
(Mus musculus)
Dynll1 [ciliary tip]
(Rattus norvegicus)
dlc-4 [ciliary tip]
(Caenorhabditis elegans)
DYNLL1 [ciliary tip]
(Bos taurus)
DYNLL1 [ciliary tip]
(Canis familiaris)
DYNLL1 [ciliary tip]
(Gallus gallus)
DYNLL1 [ciliary tip]
(Sus scrofa)
Homologues of DYNLL1 [ciliary tip]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001032583.1
,
NP_001032584.1
,
NP_003737.1
OpenTargets
ENSG00000088986
HPA
ENSG00000088986-DYNLL1
GeneCards
P63167
Ensembl
ENST00000548342
,
ENSP00000242577
,
ENST00000549989
,
ENSP00000376296
,
ENST00000242577
,
ENSP00000447907
,
ENSP00000446614
,
ENST00000392508
,
ENST00000392509
,
ENSP00000376297
,
ENSG00000088986
PRO
P63167
Pharos - Targets
P63167
HMDB Protein
HMDBP10685
PDB
3ZKF
,
8PR1
,
8PTK
,
6GZL
,
8RGG
,
7D35
,
1CMI
,
3ZKE
,
8PR0
,
6GZJ
,
6SC2
,
6RLB
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13627 DYRK1A
1
DYRK1A [nucleoplasm]
(R-HSA-1362267)
0.798
5
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.725
4
UniProt:Q13153 PAK1
5
PAK1 [plasma membrane]
(R-HSA-3928409)
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
Active PAK1 [cytosol]
(R-HSA-8964622)
PAK1 [cytosol]
(R-HSA-162629)
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
0.666
4
UniProt:O96015 DNAL4
1
DNAL4 [plasma membrane]
(R-HSA-177484)
0.666
5
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
10
UniProt:O14867 BACH1
5
BACH1 [nucleoplasm]
(R-HSA-9707688)
BACH1 [cytosol]
(R-HSA-9708429)
PolyUb-BACH1 [nucleoplasm]
(R-HSA-9708486)
p-Y483 BACH1 [nucleoplasm]
(R-HSA-9762202)
p-Y483 BACH1 [cytosol]
(R-HSA-9762206)
0.659
3
UniProt:O43815 STRN
5
STRN [cytosol]
(R-HSA-9037081)
STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673902)
p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673908)
STRN(1-137)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700485)
STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700467)
0.643
3
UniProt:Q14678 KANK1
3
KANK1 [nucleoplasm]
(R-HSA-9018640)
p-12Y-KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane]
(R-HSA-9673890)
KANK1(1-899)-PDGFRB(415-1106) fusion [plasma membrane]
(R-HSA-9673593)
0.643
3
UniProt:Q12888 TP53BP1
3
monoSUMO1-K-TP53BP1 [nucleoplasm]
(R-HSA-2997591)
p-S25,S1778-TP53BP1 [nucleoplasm]
(R-HSA-5683418)
TP53BP1 [nucleoplasm]
(R-HSA-61175)
0.643
3
UniProt:Q9C0C7 AMBRA1
2
p-AMBRA1 [cytosol]
(R-HSA-1632854)
AMBRA1 [cytosol]
(R-HSA-1632831)
0.638
3
UniProt:Q9NR28 DIABLO
2
DIABLO [mitochondrial intermembrane space]
(R-HSA-64637)
DIABLO [cytosol]
(R-HSA-114298)
0.638
3
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.632
6
UniProt:Q6W0C5 DPPA3
2
DPPA3 [cytosol]
(R-HSA-9818458)
DPPA3 [nucleoplasm]
(R-HSA-9817479)
0.556
5
UniProt:Q96LC9 BMF
3
p-BMF [mitochondrial outer membrane]
(R-HSA-3145026)
BMF [plasma membrane]
(R-HSA-140209)
p-BMF(1-89) [cytosol]
(R-HSA-140529)
0.556
3
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.527
2
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
4
UniProt:Q8NEZ4 KMT2C
1
KMT2C [nucleoplasm]
(R-HSA-1183224)
0.527
2
UniProt:P63208 SKP1
2
SKP1 [nucleoplasm]
(R-HSA-187538)
SKP1 [cytosol]
(R-HSA-174150)
0.527
2
UniProt:Q8IX03 WWC1
1
WWC1 [cytosol]
(R-HSA-2038400)
0.527
2
UniProt:O75330 HMMR
2
HMMR [plasma membrane]
(R-HSA-2160885)
HMMR [cytosol]
(R-HSA-8861624)
0.527
2
UniProt:Q9P289 STK26
3
MST4(306-416) [cytosol]
(R-HSA-351903)
MST4(1-305) [cytosol]
(R-HSA-351855)
MST4 [cytosol]
(R-HSA-351918)
0.527
2
UniProt:Q6PJG9 LRFN4
1
SALM3 [plasma membrane]
(R-HSA-197883)
0.527
2
UniProt:P13861 PRKAR2A
2
PRKAR2A [cytosol]
(R-HSA-57840)
PRKAR2A [ciliary base]
(R-HSA-5610412)
0.527
2
UniProt:Q9Y6E0 STK24
4
STK24(1-313) [nucleoplasm]
(R-HSA-351944)
STK24(314-443) [cytosol]
(R-HSA-351898)
STK24(1-313) [cytosol]
(R-HSA-351892)
STK24 [cytosol]
(R-HSA-351829)
0.527
2
UniProt:P49023 PXN
4
p-Y-PXN [plasma membrane]
(R-HSA-9031680)
PXN [plasma membrane]
(R-HSA-180493)
PXN [cytosol]
(R-HSA-210014)
p-Y31,Y118-PXN [cytosol]
(R-HSA-5218693)
0.527
2
UniProt:P17612 PRKACA
4
PRKACA [mitochondrial matrix]
(R-HSA-9838291)
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [cytosol]
(R-HSA-57844)
0.527
2
UniProt:Q13426 XRCC4
2
monoSUMO1-K210-XRCC4 [nucleoplasm]
(R-HSA-4568892)
XRCC4 [nucleoplasm]
(R-HSA-75911)
0.527
2
UniProt:Q6PGQ7 BORA
3
p-S252-BORA [cytosol]
(R-HSA-4086411)
p-S252,S497,T501-BORA [cytosol]
(R-HSA-3000330)
BORA [cytosol]
(R-HSA-2562607)
0.527
2
UniProt:Q14677 CLINT1
1
CLINT1 [cytosol]
(R-HSA-429811)
0.508
2
UniProt:Q16656 NRF1
1
NRF1 [nucleoplasm]
(R-HSA-1592205)
0.508
2
UniProt:Q96CV9 OPTN
6
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [cytosol]
(R-HSA-9687907)
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
0.483
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
8
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