Reactome | DYNLL1 [ciliary tip]

DYNLL1 [ciliary tip]

Stable Identifier

R-HSA-5625335

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ciliary tip

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External Reference Information

External Reference

UniProt:P63167 DYNLL1

Gene Names

DYNLL1, DLC1, DNCL1, DNCLC1, HDLC1

Chain

chain:1-89

Reference Genes

BioGPS Gene:8655 DYNLL1

COSMIC (genes):DYNLL1 DYNLL1

CTD Gene:8655 DYNLL1

dbSNP Gene:8655 DYNLL1

ENSEMBL:ENSG00000088986 DYNLL1

ENSEMBL:ENSG00000088986.11 DYNLL1

HGNC:15476 DYNLL1

KEGG Gene (Homo sapiens):8655 DYNLL1

Monarch:8655 DYNLL1

NCBI Gene:8655 DYNLL1

OMIM:601562 DYNLL1

Reference Transcript

Other Identifiers

11753833_a_at

200703_PM_at

200703_at

3059785

3434394

3434396

3434398

3434402

3434403

3434404

3434407

3434408

3434409

3434410

34891_at

3574114

3574116

7959164

7980535

8655

A_23_P65031

A_24_P124672

GE61176

GO:0000776

GO:0003774

GO:0005515

GO:0005634

GO:0005694

GO:0005737

GO:0005739

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005868

GO:0005874

GO:0005875

GO:0005886

GO:0005929

GO:0006915

GO:0007017

GO:0007018

GO:0008180

GO:0008574

GO:0012501

GO:0015630

GO:0016020

GO:0021762

GO:0030286

GO:0031410

GO:0035721

GO:0042326

GO:0043226

GO:0044458

GO:0044782

GO:0045505

GO:0048856

GO:0070821

GO:0072686

GO:0097542

GO:0101003

GO:0140657

HMNXSV003054414

ILMN_2300186

PH_hs_0035324

U32944_at

g4505812_3p_at

Participates

as a member of

dynein-2 light chains [ciliary tip] (Homo sapiens)

Other forms of this molecule

DYNLL1 [cytosol]

DYNLL1 [plasma membrane]

DYNLL1 [tertiary granule membrane]

DYNLL1 [ficolin-1-rich granule membrane]

DYNLL1 [cilium]

Inferred To

dlc-6 [ciliary tip] (Caenorhabditis elegans)

dynll2 [ciliary tip] (Danio rerio)

dlc-3 [ciliary tip] (Caenorhabditis elegans)

dlc-1 [ciliary tip] (Caenorhabditis elegans)

dlc-2 [ciliary tip] (Caenorhabditis elegans)

dlc-5 [ciliary tip] (Caenorhabditis elegans)

Dynll1 [ciliary tip] (Mus musculus)

Dynll1 [ciliary tip] (Rattus norvegicus)

dlc-4 [ciliary tip] (Caenorhabditis elegans)

DYNLL1 [ciliary tip] (Bos taurus)

DYNLL1 [ciliary tip] (Canis familiaris)

DYNLL1 [ciliary tip] (Gallus gallus)

DYNLL1 [ciliary tip] (Sus scrofa)

Homologues of DYNLL1 [ciliary tip] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001032584.1, NP_003737.1, NP_001032583.1

OpenTargets

ENSG00000088986

GeneCards

P63167

HPA

ENSG00000088986-DYNLL1

Ensembl

ENST00000548342, ENSP00000447907, ENSP00000242577, ENSP00000446614, ENSP00000376296, ENST00000549989, ENST00000392508, ENST00000242577, ENST00000392509, ENSG00000088986, ENSP00000376297

PRO

P63167

Pharos - Targets

P63167

HMDB Protein

HMDBP10685

PDB

6RLB, 7D35, 6GZL, 1CMI, 3ZKF, 3ZKE, 6SC2, 6GZJ

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13153 PAK1	6	p-S144-PAK1 [cytosol] (R-HSA-451339) PAK1 [plasma membrane] (R-HSA-3928409) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) Active PAK1 [cytosol] (R-HSA-8964622) PAK1 [cytosol] (R-HSA-162629) p-S144,T423-PAK1 [cytosol] (R-HSA-399819)	0.666	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.632	6
UniProt:O96015 DNAL4	1	DNAL4 [plasma membrane] (R-HSA-177484)	0.556	3
UniProt:Q96LC9 BMF	3	BMF [plasma membrane] (R-HSA-140209) p-BMF(1-89) [cytosol] (R-HSA-140529) p-BMF [mitochondrial outer membrane] (R-HSA-3145026)	0.556	3
UniProt:Q6W0C5 DPPA3	2	DPPA3 [cytosol] (R-HSA-9818458) DPPA3 [nucleoplasm] (R-HSA-9817479)	0.556	5
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.547	2
UniProt:Q9Y6E0 STK24	4	STK24(1-313) [nucleoplasm] (R-HSA-351944) STK24(314-443) [cytosol] (R-HSA-351898) STK24(1-313) [cytosol] (R-HSA-351892) STK24 [cytosol] (R-HSA-351829)	0.527	2
UniProt:Q16656 NRF1	1	NRF1 [nucleoplasm] (R-HSA-1592205)	0.508	2
UniProt:Q14677 CLINT1	1	CLINT1 [cytosol] (R-HSA-429811)	0.508	2
UniProt:P98170 XIAP	3	K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366) XIAP [cytosol] (R-HSA-50849)	0.508	2
UniProt:Q9NR28 DIABLO	2	DIABLO [mitochondrial intermembrane space] (R-HSA-64637) DIABLO [cytosol] (R-HSA-114298)	0.508	2
UniProt:Q9C0C7 AMBRA1	2	p-AMBRA1 [cytosol] (R-HSA-1632854) AMBRA1 [cytosol] (R-HSA-1632831)	0.508	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	8

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