Reactome | PGD [cytosol]

PGD [cytosol]

Stable Identifier

R-HSA-71297

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

phosphogluconate dehydrogenase, 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate 2-dehydrogenase

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        NFE2L2 regulates pentose phosphate pathway genes (Homo sapiens)
        
        NFE2L2-dependent PGD gene expression (Homo sapiens)
        
        PGD dimer [cytosol] (Homo sapiens)
        
        PGD [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P52209 PGD

Gene Names

PGD, PGDH

Chain

chain:1-483

Reference Genes

BioGPS Gene:5226 PGD

COSMIC (genes):PGD PGD

CTD Gene:5226 PGD

dbSNP Gene:5226 PGD

ENSEMBL:ENSG00000142657 PGD

ENSEMBL_homo_sapiens_GENE:ENSG00000142657.21 PGD

HGNC:8891 PGD

KEGG Gene (Homo sapiens):5226 PGD

Monarch:5226 PGD

NCBI Gene:5226 PGD

OMIM:172200 PGD

UCSC:P52209 PGD

Reference Transcript

Other Identifiers

11723205_a_at

11746023_a_at

16658864

201118_PM_at

201118_at

2319804

2319806

2319808

2319810

2319813

2319815

2319819

2319823

2319825

2319826

2319827

2319829

2319830

2319831

36963_at

3783707

5226

71426_f_at

7897620

A_23_P126623

GE59066

GO:0003824

GO:0004616

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005975

GO:0006091

GO:0006098

GO:0009051

GO:0016491

GO:0019322

GO:0019521

GO:0043226

GO:0046177

GO:0050661

GO:0055086

GO:0070062

GO:1901135

HMNXSV003052054

ILMN_1794165

TC01000129.hg

U30255_at

g4505758_3p_s_at

Participates

as a component of

PGD dimer [cytosol] (Homo sapiens)

Inferred To

PGD [cytosol] (Bos taurus)

PGD [cytosol] (Caenorhabditis elegans)

PGD [cytosol] (Canis familiaris)

PGD [cytosol] (Danio rerio)

PGD [cytosol] (Dictyostelium discoideum)

PGD [cytosol] (Drosophila melanogaster)

PGD [cytosol] (Gallus gallus)

PGD [cytosol] (Mus musculus)

PGD [cytosol] (Rattus norvegicus)

PGD [cytosol] (Saccharomyces cerevisiae)

PGD [cytosol] (Schizosaccharomyces pombe)

PGD [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001291380.1, NP_001291381.1, NP_002622.2

OpenTargets

ENSG00000142657

ZINC - Substances

6PGD_HUMAN

ZINC target

P52209

ZINC - Biogenic

6PGD_HUMAN

PRO

P52209

PDB

5UQ9, 2JKV, 4GWK, 4GWG

ZINC - Investigational

6PGD_HUMAN

ZINC - Metabolites

6PGD_HUMAN

IntEnz

1.1.1.44

HPA

ENSG00000142657-PGD

GeneCards

P52209

Ensembl

ENSG00000142657, ENST00000270776, ENSP00000270776

Pharos - Targets

P52209

ZINC - Predictions - Purchasable

6PGD_HUMAN

Orphanet

24805

HMDB Protein

HMDBP01039

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	5

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