Reactome | SEC16A [cytosol]

SEC16A [cytosol]

Stable Identifier

R-HSA-5685728

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
        
        SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
        
        Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
      - SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
      - Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15027 SEC16A

Gene Names

SEC16A, KIAA0310, SEC16, SEC16L

Chain

chain:1-2357

Reference Genes

BioGPS Gene:9919 SEC16A

COSMIC (genes):SEC16A SEC16A

CTD Gene:9919 SEC16A

dbSNP Gene:9919 SEC16A

ENSEMBL:ENSG00000148396 SEC16A

HGNC:29006 SEC16A

KEGG Gene (Homo sapiens):9919 SEC16A

Monarch:9919 SEC16A

NCBI Gene:9919 SEC16A

OMIM:612854 SEC16A

UCSC:O15027 SEC16A

Reference Transcript

Other Identifiers

0003840050

0102230672

11715699_s_at

11746007_a_at

11752727_a_at

11754099_a_at

11754100_x_at

17099980

215696_s_at

3230018

3230019

3230020

3230021

3230022

3230023

3230025

3230026

3230027

3230028

3230029

3230036

3230037

3230039

3230041

3230042

3230044

3230047

3230049

3230050

3230053

3230055

3230061

3230064

3230065

3230066

3230067

3230068

3230073

3230074

3230076

3230079

3230081

3230083

3230084

3230085

3230088

3230089

3230091

3230092

3230093

3230094

3230095

3230096

3230097

3230098

3230099

3230101

3230102

3230104

3230106

3230108

3230110

3230112

3230114

3230116

3230118

3230120

3230122

35313_at

8165183

9919

A_23_P251303

A_33_P3382267

GE79996

GO:0000139

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0006810

GO:0006888

GO:0006950

GO:0007029

GO:0007030

GO:0008150

GO:0012507

GO:0015031

GO:0016020

GO:0016192

GO:0021762

GO:0022607

GO:0031090

GO:0031410

GO:0032527

GO:0034976

GO:0043000

GO:0043226

GO:0043231

GO:0048208

GO:0048471

GO:0048856

GO:0050821

GO:0061024

GO:0065003

GO:0070863

GO:0070971

GO:0070973

GO:0072659

Hs.5716.1.A1_3p_a_at

ILMN_2126344

TC09001732.hg

Participant Of

hasComponent

SEC16A:SEC16B [cytosol]

Inferred To

Ghost homologue of SEC16A [cytosol] (Danio rerio)

sec-16a.2 [cytosol] (Caenorhabditis elegans)

SEC16A [cytosol] (Bos taurus)

SEC16A [cytosol] (Canis familiaris)

SEC16A [cytosol] (Gallus gallus)

SEC16A [cytosol] (Sus scrofa)

SEC16A [cytosol] (Xenopus tropicalis)

Sec16 [cytosol] (Drosophila melanogaster)

Sec16a [cytosol] (Mus musculus)

Sec16a [cytosol] (Rattus norvegicus)

sec16 [cytosol] (Schizosaccharomyces pombe)

wimA [cytosol] (Dictyostelium discoideum)

SEC16 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

XP_011517559.1, XP_011517557.1, XP_005266191.1, XP_011517562.1, XP_011517554.1, XP_011517550.1, NP_001263347.1, XP_011517549.1, XP_011517548.1, XP_011517561.1, NP_055681.1

OpenTargets

ENSG00000148396

GeneCards

O15027

HPA

ENSG00000148396-SEC16A

Ensembl

ENST00000313050, ENSP00000325827, ENSG00000148396

PRO

O15027

HMDB Protein

HMDBP08575

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.649	8
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cilium] (R-HSA-5632507) CSNK1A1 [cytosol] (R-HSA-195263)	0.527	2
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.527	2
UniProt:Q96GD4 AURKB	3	AURKB [nucleoplasm] (R-HSA-4655360) SUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [cytosol] (R-HSA-174231)	0.462	2
UniProt:P49841 GSK3B	4	p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B del304-316 [cytosol] (R-HSA-5339682) GSK3B [cytosol] (R-HSA-2997551) GSK3B [nucleoplasm] (R-HSA-2022823)	0.462	2
UniProt:O15155 BET1	3	BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142) BET1 [transport vesicle] (R-HSA-6808719) BET1 [Golgi membrane] (R-HSA-6807743)	0.462	2

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