Reactome | SEC16A [cytosol]

SEC16A [cytosol]

Stable Identifier

R-HSA-5685728

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
        
        SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
        
        Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
      - SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
      - Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)
        
        SEC16A:SEC16B [cytosol] (Homo sapiens)
        
        SEC16A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15027 SEC16A

Gene Names

SEC16A, KIAA0310, SEC16, SEC16L

Chain

chain:1-2357

Reference Genes

BioGPS Gene:9919 SEC16A

COSMIC (genes):SEC16A SEC16A

CTD Gene:9919 SEC16A

dbSNP Gene:9919 SEC16A

ENSEMBL:ENSG00000148396 SEC16A

HGNC:29006 SEC16A

KEGG:hsa:9919 SEC16A

Monarch:9919 SEC16A

NCBI Gene:9919 SEC16A

OMIM:612854 SEC16A

UCSC:O15027 SEC16A

Reference Transcript

Other Identifiers

11715699_s_at

11746007_a_at

11752727_a_at

11754099_a_at

11754100_x_at

11762697_at

17099980

215696_PM_s_at

215696_s_at

3230018

3230019

3230020

3230021

3230022

3230023

3230025

3230026

3230027

3230028

3230029

3230036

3230037

3230038

3230039

3230041

3230042

3230044

3230045

3230047

3230049

3230050

3230053

3230054

3230055

3230057

3230059

3230060

3230061

3230062

3230063

3230064

3230065

3230066

3230067

3230068

3230073

3230074

3230076

3230079

3230081

3230083

3230084

3230085

3230086

3230087

3230088

3230089

3230090

3230091

3230092

3230093

3230094

3230095

3230096

3230097

3230098

3230099

3230101

3230102

3230104

3230106

3230108

3230110

3230112

3230114

3230116

3230118

3230120

3230122

3230128

3230129

3230130

3230131

35313_at

8165183

9919

A_23_P251303

A_33_P3382267

GE79996

GO:0000139

GO:0003400

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0006886

GO:0006888

GO:0006893

GO:0007029

GO:0007030

GO:0012507

GO:0015031

GO:0016020

GO:0016192

GO:0021762

GO:0031090

GO:0032527

GO:0034976

GO:0043226

GO:0046907

GO:0048471

GO:0048856

GO:0050821

GO:0070971

GO:0070973

GO:0072659

HMNXSV003033966

HMNXSV003053394

Hs.5716.1.A1_3p_a_at

ILMN_2126344

TC09001732.hg

Participates

as a component of

SEC16A:SEC16B [cytosol] (Homo sapiens)

Inferred To

Ghost homologue of SEC16A [cytosol] (Plasmodium falciparum)

Ghost homologue of SEC16A [cytosol] (Xenopus tropicalis)

sec-16a.2 [cytosol] (Caenorhabditis elegans)

SEC16A [cytosol] (Bos taurus)

SEC16A [cytosol] (Canis familiaris)

SEC16A [cytosol] (Gallus gallus)

SEC16A [cytosol] (Sus scrofa)

Sec16 [cytosol] (Drosophila melanogaster)

Sec16a [cytosol] (Mus musculus)

Sec16a [cytosol] (Rattus norvegicus)

sec16 [cytosol] (Schizosaccharomyces pombe)

wimA [cytosol] (Dictyostelium discoideum)

SEC16 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

XP_047280189.1, XP_005266191.1, XP_054220366.1, XP_054220376.1, XP_011517554.1, XP_054220364.1, NP_001263347.1, XP_054220358.1, NP_055681.1, XP_047280185.1, XP_011517559.1, XP_011517557.1, XP_011517549.1, XP_047280195.1, XP_011517548.1, XP_054220373.1, XP_011517550.1, XP_011517561.1, XP_011517562.1, XP_047280191.1

OpenTargets

ENSG00000148396

ENSEMBL

ENSG00000148396, ENST00000684901, ENSP00000508822, ENSP00000325827, ENST00000313050

HPA

ENSG00000148396-SEC16A

GeneCards

SEC16A

PRO

O15027

Pharos - Targets

O15027

GlyGen

O15027

HMDB Protein

HMDBP08575

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.725	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.649	8
UniProt:P55735 SEC13	4	SEC13 [cytosol] (R-HSA-203981) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994) SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012) SEC13 [lysosomal membrane] (R-HSA-9638246)	0.643	5
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	12
UniProt:Q96GD4 AURKB	3	AURKB [cytosol] (R-HSA-174231) AURKB [nucleoplasm] (R-HSA-4655360) polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414)	0.569	3
UniProt:P49674 CSNK1E	2	CSNK1E [cytosol] (R-HSA-205877) CSNK1E [nucleoplasm] (R-HSA-421306)	0.527	2
UniProt:Q9BY84 DUSP16	3	DUSP16 [cytosol] (R-HSA-5675336) DUSP16 [nucleoplasm] (R-HSA-5675337) Ac-55-DUSP16 [cytosol] (R-HSA-9636576)	0.527	2
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.527	2
UniProt:P51617 IRAK1	14	IRAK1 [cytosol] (R-HSA-446639) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) IRAK1 [plasma membrane] (R-HSA-937045) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) IRAK1 [endosome membrane] (R-HSA-975127) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) p-T209-IRAK1 [endosome membrane] (R-HSA-975189) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) p-S,T-IRAK1 [cytosol] (R-HSA-3149574) K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) p-S376,T387-IRAK1 [cytosol] (R-HSA-446687)	0.527	2
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.483	2

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