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SEC16A [cytosol]
Stable Identifier
R-HSA-5685728
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEC16A:SEC16B [cytosol] (Homo sapiens)
SEC16A [cytosol] (Homo sapiens)
SEC16A:SEC16B [cytosol] (Homo sapiens)
SEC16A [cytosol] (Homo sapiens)
SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEC16A:SEC16B [cytosol] (Homo sapiens)
SEC16A [cytosol] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEC16A:SEC16B [cytosol] (Homo sapiens)
SEC16A [cytosol] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEC16A:SEC16B [cytosol] (Homo sapiens)
SEC16A [cytosol] (Homo sapiens)
SEC16A:SEC16B [cytosol] (Homo sapiens)
SEC16A [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPII-mediated vesicle transport (Homo sapiens)
SEC16 complex binds SAR1B:GTP:SEC23:SEC24 (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEC16A:SEC16B [cytosol] (Homo sapiens)
SEC16A [cytosol] (Homo sapiens)
SEC16A:SEC16B [cytosol] (Homo sapiens)
SEC16A [cytosol] (Homo sapiens)
SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEC16A:SEC16B [cytosol] (Homo sapiens)
SEC16A [cytosol] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEC16A:SEC16B [cytosol] (Homo sapiens)
SEC16A [cytosol] (Homo sapiens)
Vesicle budding (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane] (Homo sapiens)
SEC16A:SEC16B [cytosol] (Homo sapiens)
SEC16A [cytosol] (Homo sapiens)
SEC16A:SEC16B [cytosol] (Homo sapiens)
SEC16A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15027 SEC16A
Gene Names
SEC16A, KIAA0310, SEC16, SEC16L
Chain
chain:1-2357
Reference Genes
BioGPS Gene:9919 SEC16A
COSMIC (genes):SEC16A SEC16A
CTD Gene:9919 SEC16A
dbSNP Gene:9919 SEC16A
ENSEMBL:ENSG00000148396 SEC16A
HGNC:29006 SEC16A
KEGG Gene (Homo sapiens):9919 SEC16A
Monarch:9919 SEC16A
NCBI Gene:9919 SEC16A
OMIM:612854 SEC16A
UCSC:O15027 SEC16A
Reference Transcript
RefSeq:NM_001276418.1 SEC16A
RefSeq:XM_011519255.2 SEC16A
RefSeq:XM_011519246.2 SEC16A
RefSeq:XM_011519252.2 SEC16A
RefSeq:NM_014866.1 SEC16A
RefSeq:XM_011519247.1 SEC16A
RefSeq:XM_005266134.2 SEC16A
RefSeq:XM_011519259.1 SEC16A
RefSeq:XM_011519248.2 SEC16A
RefSeq:XM_011519260.2 SEC16A
RefSeq:XM_011519257.1 SEC16A
Other Identifiers
0003840050
0102230672
11715699_s_at
11746007_a_at
11752727_a_at
11754099_a_at
11754100_x_at
17099980
215696_PM_s_at
215696_s_at
3230018
3230019
3230020
3230021
3230022
3230023
3230025
3230026
3230027
3230028
3230029
3230036
3230037
3230039
3230041
3230042
3230044
3230047
3230049
3230050
3230053
3230055
3230061
3230064
3230065
3230066
3230067
3230068
3230073
3230074
3230076
3230079
3230081
3230083
3230084
3230085
3230088
3230089
3230091
3230092
3230093
3230094
3230095
3230096
3230097
3230098
3230099
3230101
3230102
3230104
3230106
3230108
3230110
3230112
3230114
3230116
3230118
3230120
3230122
35313_at
8165183
9919
A_23_P251303
A_33_P3382267
GE79996
GO:0000139
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0006810
GO:0006888
GO:0006914
GO:0006950
GO:0007029
GO:0007030
GO:0008150
GO:0009056
GO:0012507
GO:0015031
GO:0016020
GO:0016192
GO:0021762
GO:0022607
GO:0031090
GO:0031410
GO:0032527
GO:0034976
GO:0043000
GO:0043226
GO:0043231
GO:0048208
GO:0048471
GO:0048856
GO:0050821
GO:0061024
GO:0065003
GO:0070971
GO:0070973
GO:0072659
HMNXSV003033966
HMNXSV003053394
Hs.5716.1.A1_3p_a_at
ILMN_2126344
TC09001732.hg
Participates
as a component of
SEC16A:SEC16B [cytosol] (Homo sapiens)
Inferred To
Ghost homologue of SEC16A [cytosol]
(Danio rerio)
Ghost homologue of SEC16A [cytosol]
(Xenopus tropicalis)
sec-16a.2 [cytosol]
(Caenorhabditis elegans)
SEC16A [cytosol]
(Bos taurus)
SEC16A [cytosol]
(Canis familiaris)
SEC16A [cytosol]
(Gallus gallus)
SEC16A [cytosol]
(Sus scrofa)
Sec16 [cytosol]
(Drosophila melanogaster)
Sec16a [cytosol]
(Mus musculus)
Sec16a [cytosol]
(Rattus norvegicus)
sec16 [cytosol]
(Schizosaccharomyces pombe)
wimA [cytosol]
(Dictyostelium discoideum)
sec-16A.1 [cytosol]
(Caenorhabditis elegans)
Homologues of SEC16A [cytosol]
(Caenorhabditis elegans)
SEC16 [cytosol]
(Saccharomyces cerevisiae)
Cross References
RefSeq
XP_011517548.1
,
NP_001263347.1
,
XP_011517562.1
,
XP_011517561.1
,
NP_055681.1
,
XP_011517550.1
,
XP_011517557.1
,
XP_011517554.1
,
XP_011517559.1
,
XP_005266191.1
,
XP_011517549.1
OpenTargets
ENSG00000148396
HPA
ENSG00000148396-SEC16A
GeneCards
O15027
Ensembl
ENSP00000325827
,
ENSG00000148396
,
ENST00000313050
PRO
O15027
Pharos - Targets
O15027
HMDB Protein
HMDBP08575
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.649
8
UniProt:P48729 CSNK1A1
2
CSNK1A1 [cytosol]
(R-HSA-195263)
CSNK1A1 [cilium]
(R-HSA-5632507)
0.643
3
UniProt:Q96GD4 AURKB
3
polySUMO2,3-K202-AURKB [cytosol]
(R-HSA-4655414)
AURKB [nucleoplasm]
(R-HSA-4655360)
AURKB [cytosol]
(R-HSA-174231)
0.569
3
UniProt:P49674 CSNK1E
2
CSNK1E [cytosol]
(R-HSA-205877)
CSNK1E [nucleoplasm]
(R-HSA-421306)
0.527
2
UniProt:P51617 IRAK1
14
K63polyUb-hp-IRAK1 [endosome membrane]
(R-HSA-975112)
p-S376,T387-IRAK1 [cytosol]
(R-HSA-446687)
p-S,T-IRAK1 [cytosol]
(R-HSA-3149574)
K63polyUb-hp-IRAK1 [cytosol]
(R-HSA-451565)
p-T209-IRAK1 [endosome membrane]
(R-HSA-975189)
p-T209,T387-IRAK1 [endosome membrane]
(R-HSA-975117)
IRAK1 [endosome membrane]
(R-HSA-975127)
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
(R-HSA-975157)
IRAK1 [plasma membrane]
(R-HSA-937045)
p-T209-IRAK1 [plasma membrane]
(R-HSA-937031)
p-T209,T387-IRAK1 [plasma membrane]
(R-HSA-166279)
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
(R-HSA-937011)
IRAK1 [cytosol]
(R-HSA-446639)
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
(R-HSA-446682)
0.527
2
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.483
2
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