Reactome | DDOST [plasma membrane]

DDOST [plasma membrane]

Stable Identifier

R-HSA-879386

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Ost48, AGER1, Oligosaccharyl transferase 48 kDa subunit, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P39656 DDOST

Gene Names

DDOST, KIAA0115, OST48, OK/SW-cl.45

Chain

signal peptide:1-42, chain:43-456

Reference Genes

BioGPS Gene:1650 DDOST

COSMIC (genes):DDOST DDOST

CTD Gene:1650 DDOST

dbSNP Gene:1650 DDOST

ENSEMBL:ENSG00000244038 DDOST

HGNC:2728 DDOST

KEGG:hsa:1650 DDOST

Monarch:1650 DDOST

NCBI Gene:1650 DDOST

OMIM:602202 DDOST

UCSC:P39656 DDOST

Reference Transcript

RefSeq:NM_005216.4 DDOST

Other Identifiers

11744057_x_at

11744058_a_at

11749195_x_at

1650

16682842

208674_3p_x_at

208674_PM_x_at

208674_x_at

208675_PM_s_at

208675_s_at

2400221

2400222

2400223

2400224

2400225

2400226

2400228

2400230

2400231

2400232

2400233

2400234

2400236

2400237

2400240

2400241

2400242

2400244

2400245

2400246

38791_at

49030_s_at

7913256

87217_at

A_23_P149099

D29643_at

GE796417

GE81479

GE84090

GO:0002376

GO:0005515

GO:0005783

GO:0005789

GO:0005886

GO:0006486

GO:0006487

GO:0008047

GO:0008250

GO:0016020

GO:0018279

GO:0031647

GO:0034097

GO:0035577

GO:0042110

GO:0043226

GO:0043231

GO:0098772

HMNXSV003010875

HMNXSV003045713

ILMN_1734231

PH_hs_0023611

PH_hs_0035771

TC01002316.hg

g473936_3p_a_at

Participates

as a member of

Other forms of this molecule

DDOST [azurophil granule membrane]

DDOST [endoplasmic reticulum membrane]

Inferred To

DDOST [plasma membrane] (Bos taurus)

DDOST [plasma membrane] (Canis familiaris)

DDOST [plasma membrane] (Gallus gallus)

DDOST [plasma membrane] (Plasmodium falciparum)

DDOST [plasma membrane] (Sus scrofa)

ddost [plasma membrane] (Danio rerio)

ddost [plasma membrane] (Dictyostelium discoideum)

ddost [plasma membrane] (Xenopus tropicalis)

wbp1 [plasma membrane] (Schizosaccharomyces pombe)

WBP1 [plasma membrane] (Saccharomyces cerevisiae)

ostb-1 [plasma membrane] (Caenorhabditis elegans)

Ddost [plasma membrane] (Mus musculus)

Ddost [plasma membrane] (Rattus norvegicus)

Ost48 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_005207.2

ENSEMBL

ENST00000415136, ENSP00000399457

OpenTargets

ENSG00000244038

ZINC - Substances

OST48_HUMAN

ZINC target

P39656

PRO

P39656

GlyGen

P39656

PDB

6S7T, 6S7O, 8PN9, 8B6L

HPA

ENSG00000244038-DDOST

Pharos - Targets

P39656

Orphanet

DDOST

ZINC - Predictions - Purchasable

OST48_HUMAN

HMDB Protein

HMDBP01591

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.569	5
UniProt:Q14165 MLEC	3	MLEC [endoplasmic reticulum membrane] (R-HSA-901082) MLEC [plasma membrane] (R-HSA-6806292) MLEC [specific granule membrane] (R-HSA-6799618)	0.564	2
UniProt:Q86WV6 STING1	5	STING [endoplasmic reticulum membrane] (R-HSA-1834940) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) TMEM173 [secretory granule membrane] (R-HSA-6804798) TMEM173 [plasma membrane] (R-HSA-6804815)	0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	10

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