Reactome | SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane]

SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane]

Stable Identifier

R-HSA-5688566

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O75396 SEC22B

Gene Names

SEC22B, SEC22L1

Chain

initiator methionine:, chain:2-215

Reference Genes

BioGPS Gene:9554 SEC22B

COSMIC (genes):SEC22B SEC22B

CTD Gene:9554 SEC22B

dbSNP Gene:9554 SEC22B

ENSEMBL:ENSG00000265808 SEC22B

HGNC:10700 SEC22B

KEGG:hsa:9554 SEC22B

Monarch:9554 SEC22B

NCBI Gene:9554 SEC22B

OMIM:604029 SEC22B

UCSC:O75396 SEC22B

Reference Transcript

RefSeq:NM_004892.5 SEC22B

Other Identifiers

11728713_at

11764116_s_at

16669700

209206_PM_at

209206_at

209207_PM_s_at

209207_s_at

231890_PM_at

231890_at

233020_PM_at

233020_at

2355618

2355619

2355620

2355621

2355622

2355623

2355624

2355625

2355632

2355634

2355636

2355637

2355639

2431270

2431272

2431273

2431274

2431275

2431276

41597_s_at

67573_at

68654_at

7904695

87895_s_at

9554

A_23_P200815

A_23_P412392

GE54410

GE757151

GO:0000139

GO:0005484

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0005793

GO:0005794

GO:0006888

GO:0006890

GO:0012505

GO:0012507

GO:0015031

GO:0016020

GO:0016192

GO:0030133

GO:0030670

GO:0031201

GO:0031410

GO:0033116

GO:0042470

GO:0043226

GO:0043231

GO:0045732

GO:0048280

GO:0060090

GO:0061024

GO:0061025

GO:1902902

HMNXSV003004443

Hs.273830.0.S1_3p_at

Hs.283130.0.S1_3p_at

Hs.50785.0.A2_3p_at

ILMN_1784238

ILMN_1887230

PH_hs_0023109

PH_hs_0036746

TC01001086.hg

g12655032_3p_a_at

Participates

as an output of

Transport of SEC22B, TAP and PLC from ER to ERGIC (Homo sapiens)

as an input of

SEC22B, CALR, STX4, TAP and TAPBP bind (Homo sapiens)

as a component of

CALR:SEC22B:STX4:TAP:TAPBP [phagocytic vesicle membrane] (Homo sapiens)

as a member of

ER-to-ERGIC v-SNARES [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

Other forms of this molecule

SEC22B [endoplasmic reticulum membrane]

SEC22B [ER to Golgi transport vesicle membrane]

SEC22B [phagocytic vesicle membrane]

SEC22B [transport vesicle]

SEC22B [Golgi membrane]

Inferred To

sec22b [endoplasmic reticulum-Golgi intermediate compartment membrane] (Xenopus tropicalis)

Sec22b [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)

Sec22b [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)

SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)

SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)

SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (Dictyostelium discoideum)

SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (Gallus gallus)

SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (Plasmodium falciparum)

SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)

sec22bb [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)

sec22 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Schizosaccharomyces pombe)

SEC22 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Saccharomyces cerevisiae)

Sec22 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Drosophila melanogaster)

sec-22 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)

Cross References

OpenTargets

ENSG00000265808

ENSEMBL

ENSP00000463393, ENST00000578049

HPA

ENSG00000265808-SEC22B

PRO

O75396

Pharos - Targets

O75396

GlyGen

O75396

PDB

3EGX, 2NUP, 2NUT, 3EGD, 8HR0

Interactors (75)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9P2W9 STX18	1	STX18 [endoplasmic reticulum membrane] (R-HSA-2029079)	0.773	6
UniProt:P54920 NAPA	1	NAPA [cytosol] (R-HSA-264469)	0.725	6
UniProt:Q12846 STX4	4	STX4 [plasma membrane] (R-HSA-181519) STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.675	4
UniProt:O15155 BET1	3	BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142) BET1 [transport vesicle] (R-HSA-6808719) BET1 [Golgi membrane] (R-HSA-6807743)	0.671	5
UniProt:Q13190 STX5	5	STX5 [cytosol] (R-HSA-9613991) STX5 [Golgi membrane] (R-HSA-6807771) STX5 [ER to Golgi transport vesicle membrane] (R-HSA-5689838) STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688157) STX5 [endoplasmic reticulum membrane] (R-HSA-5689474)	0.669	4
UniProt:Q8WVM8 SCFD1	1	SCFD1 [cytosol] (R-HSA-5688147)	0.643	5
UniProt:Q12981 BNIP1	1	BNIP1 [endoplasmic reticulum membrane] (R-HSA-6810950)	0.643	4
UniProt:O43264 ZW10	1	ZW10 [cytosol] (R-HSA-377880)	0.643	4
UniProt:P43628 KIR2DL3	1	KIR2DL3 [plasma membrane] (R-HSA-3006532)	0.556	3
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.556	3
UniProt:Q8NC24 RELL2			0.556	3
UniProt:P11912 CD79A	2	p-Y188,Y199-CD79A [plasma membrane] (R-HSA-983539) CD79A [plasma membrane] (R-HSA-197154)	0.556	3
UniProt:Q8NBQ5 HSD17B11	1	HSD17B11 [cytosol] (R-HSA-5693370)	0.556	3
UniProt:Q86WI0 LHPL1			0.556	3
UniProt:P48165 GJA8	1	GJA8 [endoplasmic reticulum membrane] (R-HSA-190702)	0.556	3
UniProt:Q8TBP5 F174A			0.556	3
UniProt:Q8IV31 TM139			0.556	3
UniProt:Q8TDT2 GP152			0.556	3
UniProt:P38484 IFNGR2	1	IFNGR2 [plasma membrane] (R-HSA-629620)	0.556	3
IntAct:EBI-22589183 CCSB ORF ID			0.556	3
UniProt:Q8N183 NDUFAF2	1	NDUFAF2 [mitochondrial inner membrane] (R-HSA-5689129)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:Q6N075 MFSD5			0.556	3
UniProt:Q8TAF8 LHFPL5	1	LHFPL5 [plasma membrane] (R-HSA-9658860)	0.556	3
UniProt:O95377 GJB5	1	GJB5 [endoplasmic reticulum membrane] (R-HSA-190643)	0.556	3
UniProt:O95452 GJB6	1	GJB6 [endoplasmic reticulum membrane] (R-HSA-190633)	0.556	3
UniProt:Q9H6H4 REEP4			0.556	3
UniProt:O14880 MGST3	1	MGST3 [endoplasmic reticulum membrane] (R-HSA-176053)	0.556	3
UniProt:Q5JX71 F209A			0.556	3
UniProt:P31937 HIBADH	1	HIBADH [mitochondrial matrix] (R-HSA-70882)	0.556	3
UniProt:Q8N5M9 JAGN1			0.556	3
UniProt:Q7Z5P4 HSD17B13	1	HSD17B13 [cytosol] (R-HSA-8862029)	0.556	3
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:Q9Y676 MRPS18B	1	MRPS18B [mitochondrial inner membrane] (R-HSA-5368234)	0.556	3
UniProt:Q8NBD8 T229B			0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:Q9NRX6 KISHB			0.556	3
UniProt:Q96MV1 TLCD4			0.556	3
UniProt:Q7Z7G2 CPLX4			0.556	3
UniProt:Q5T7V8 GORAB			0.556	3
UniProt:O95870 ABHGA			0.556	3
UniProt:P58418 CLRN1			0.556	3
UniProt:O95471 CLDN7	2	CLDN7 [plasma membrane] (R-HSA-420004) CLDN7 [cell junction] (R-HSA-421241)	0.556	3
UniProt:Q8TED1 GPX8	1	GPX8 [endoplasmic reticulum lumen] (R-HSA-3341303)	0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:Q9NQQ7-3 Q9NQQ73			0.556	3
UniProt:Q6ZMG9-2 Q6ZMG92			0.556	3
UniProt:P32856-2 STX2			0.556	3
UniProt:Q9GZY8-5 MFF			0.556	3
UniProt:Q8TBE3 FNDC9			0.556	3
UniProt:Q99735 MGST2	1	MGST2 [endoplasmic reticulum membrane] (R-HSA-176058)	0.556	3
UniProt:Q8TEB9 RHBL4			0.556	3
IntAct:EBI-23642082 CCSB ORF ID			0.556	3
UniProt:Q96DZ7 T4S19			0.556	3
UniProt:Q9NVV5-2 AIG1			0.556	3
UniProt:Q9P2X0-2 DPM3			0.556	3
UniProt:Q9GZR5 ELOVL4	1	ELOVL4 [endoplasmic reticulum membrane] (R-HSA-548705)	0.556	3
UniProt:Q8WU76 SCFD2			0.527	3
UniProt:Q9NZ43 USE1	1	USE1 [endoplasmic reticulum membrane] (R-HSA-2193119)	0.527	3
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.527	3
UniProt:Q5SQN1 SNP47			0.527	3
UniProt:Q9UEU0 VTI1B	2	VTI1B [extracellular region] (R-HSA-8862983) VTI1B [platelet alpha granule lumen] (R-HSA-8862964)	0.527	3
UniProt:O95249 GOSR1	2	GOSR1 [transport vesicle] (R-HSA-6784834) GOSR1 [Golgi membrane] (R-HSA-6807753)	0.527	3
UniProt:Q99747 NAPG	1	NAPG [cytosol] (R-HSA-5688555)	0.527	3
UniProt:A2RU67 F234B			0.527	2
UniProt:Q9UFG5 CS025			0.527	3
UniProt:Q9UNK0 STX8			0.527	4
UniProt:Q2M389 WASC4			0.527	3
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.527	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:Q16880 UGT8	1	UGT8 [endoplasmic reticulum membrane] (R-HSA-9844570)	0.527	3
UniProt:O14653 GOSR2	4	GOSR2 [endoplasmic reticulum membrane] (R-HSA-5689451) GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-535472) GOSR2 [ER to Golgi transport vesicle membrane] (R-HSA-5689800) GOSR2 [Golgi membrane] (R-HSA-6807755)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	8

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