Pathway Browser

Visualize and interact with Reactome biological pathways

Analysis Tools

Merges pathway identifier mapping,
over-representation, and expression analysis

ReactomeFIViz

Designed to find pathways and network patterns related to cancer and other types of diseases

Documentation

Information to browse the database and use its principal tools for data analysis

Reactome Research Spotlight

Analysis of all constituents of entire Reactome pathways identified by the presence of upregulated or mutated genes helped Valdivia et al. in the February, 2023 issue of Translational Vision Science & Technology to identify druggable targets and potential drugs for the treatment of diabetic retinopathy (DR). Drugs affecting MMP13 and LGALS3 in the regulation of myeloid cell differentiation by RUNX2 were notable candidates.

ARCHIVE

Why Reactome

Reactome is a free, open-source, curated and peer-reviewed pathway database. Our goal is to provide intuitive bioinformatics tools for the visualization, interpretation and analysis of pathway knowledge to support basic research, genome analysis, modeling, systems biology and education. 

European Bioinformatics Institute (EMBL-EBI)
NYU Langone Health
Oregon Health & Science University
Ontario Institute for Cancer Research

The development of Reactome is supported by grants from the US National Institutes of Health (U24 HG012198) and the European Molecular Biology Laboratory.

Tweets

Version 83 released on December 7, 2022

2,610

Human Pathways

14,471

Reactions

11,442

Proteins

2,002

Small Molecules

1,113

Drugs

36,290

Literature References

Cite Us!