Find Reactions, Proteins and Pathways
Pathway Browser
Visualize and interact with Reactome biological pathways
Analysis Tools
Merges pathway identifier mapping,
over-representation, and expression analysis
ReactomeFIViz
Designed to find pathways and network patterns related to cancer and other types of diseases
Documentation
Information to browse the database and use its principal tools for data analysis
Reactome Research Spotlight
Analysis of all constituents of entire Reactome pathways identified by the presence of upregulated or mutated genes helped Valdivia et al. in the February, 2023 issue of Translational Vision Science & Technology to identify druggable targets and potential drugs for the treatment of diabetic retinopathy (DR). Drugs affecting MMP13 and LGALS3 in the regulation of myeloid cell differentiation by RUNX2 were notable candidates.
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Why Reactome
Reactome is a free, open-source, curated and peer-reviewed pathway database. Our goal is to provide intuitive bioinformatics tools for the visualization, interpretation and analysis of pathway knowledge to support basic research, genome analysis, modeling, systems biology and education.
The development of Reactome is supported by grants from the US National Institutes of Health (U24 HG012198) and the European Molecular Biology Laboratory.
Version 83 released on December 7, 2022
2,610
Human Pathways
14,471
Reactions
11,442
Proteins
2,002
Small Molecules
1,113
Drugs
36,290
Literature References
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