Visualize and interact with Reactome biological pathways
Merges pathway identifier mapping,
over-representation, and expression analysis
Designed to find pathways and network patterns related to cancer and other types of diseases
Information to browse the database and use its principal tools for data analysis
With current treatments, focal segmental glomerulosclerosis (FSGS), the largest cause of nephrotic syndrome, frequently progresses to end stage kidney disease. Gebeshuber et al. in the September 2023 issue of Translational Research assembled 376 FSGS-associated proteins into a FSGS pathophysiology model, major components of which were Reactome pathways for Signal transduction and Hemostasis. The 39 proteins shared between FSGS model and a 102-protein model for the antiplatelet drug clopidogrel included 20 therapeutic targets of the drug. Tested in a FSGS mouse model, clopidogrel significantly attenuated disease severity, repositioning the drug as an attractive candidate for human clinical trials for FSGS.
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