Find Reactions, Proteins and Pathways

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SURVEY

Pathway Browser

Visualize and interact with Reactome biological pathways

Analysis Tools

Merges pathway identifier mapping,
over-representation, and expression analysis

ReactomeFIViz

Designed to find pathways and network patterns related to cancer and other types of diseases

Documentation

Information to browse the database and use its principal tools for data analysis

Reactome Research Spotlight

[January 2, 2025] In the October 2024 issue of Cell Reports Medicine, Tindle et al. identified two Crohn’s disease (CD) molecular subtypes - immune-deficient infectious CD (IDICD) and stress and senescence-induced fibrostenotic CD (S2FCD) - through multi-omics and functional analyses of patient-derived organoids. Reactome pathway enrichment analysis revealed subtype-specific dysregulations. In IDICD, the Nuclear receptor transcription factor pathway, Butyrophilin family interactions and Intestinal infectious disease events were upregulated while Cytokine signaling in immune system events were downregulated. In S2FCD, Oncogene- and Oxidative stress-induced senescence pathways were upregulated and Signaling by TGF-beta receptor complex events were downregulated suggesting distinct subtype-specific therapeutic strategies.

ARCHIVE

Why Reactome

Reactome is a free, open-source, curated and peer-reviewed pathway database. Our goal is to provide intuitive bioinformatics tools for the visualization, interpretation and analysis of pathway knowledge to support basic research, genome analysis, modeling, systems biology and education. 

European Bioinformatics Institute (EMBL-EBI)
NYU Langone Health
Oregon Health & Science University
Ontario Institute for Cancer Research

The development of Reactome is supported by grants from the US National Institutes of Health (U24 HG012198) and the European Molecular Biology Laboratory.

Version 91 released on December 4, 2024

2,751

Human Pathways

15,591

Reactions

11,541

Proteins

2,125

Small Molecules

1,057

Drugs

39,806

Literature References

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