Pathway Browser

Visualize and interact with Reactome biological pathways

Analysis Tools

Merges pathway identifier mapping,
over-representation, and expression analysis

ReactomeFIViz

Designed to find pathways and network patterns related to cancer and other types of diseases

Documentation

Information to browse the database and use its principal tools for data analysis

Reactome Research Spotlight

[February 20, 2024] In the July 2023 issue of BMB Reports, Lee et al. (2023) employed the Reactome pathway database and tools to predict the anti-cancer effects of rutin, a natural phytochemical identified as a lead chemotherapeutic against breast cancer by text mining Korean traditional medicinal compendia from 1596 CE and 1613 CE. Genes that may be associated with rutin's effects were analyzed for pathway enrichment and functional interactions by the ReactomeFIViz Functional Interaction(FI)plugin app of Cytoscape. Focal adhesion and Apoptosis were among the pathways predicted to be affected by rutin and these effects were confirmed by treatment of breast cancer cells with rutin in vitro and in xenografts in mice.

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Why Reactome

Reactome is a free, open-source, curated and peer-reviewed pathway database. Our goal is to provide intuitive bioinformatics tools for the visualization, interpretation and analysis of pathway knowledge to support basic research, genome analysis, modeling, systems biology and education. 

European Bioinformatics Institute (EMBL-EBI)
NYU Langone Health
Oregon Health & Science University
Ontario Institute for Cancer Research

The development of Reactome is supported by grants from the US National Institutes of Health (U24 HG012198) and the European Molecular Biology Laboratory.

Version 87 released on December 6th, 2023

2,673

Human Pathways

15,046

Reactions

11,392

Proteins

2,120

Small Molecules

1,046

Drugs

37,933

Literature References

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