Find Reactions, Proteins and Pathways

Reactome strives to save you valuable time by placing biological knowledge, vizualizations, and analysis tools at your fingertips. If we have made a difference to your work, please take 5 minutes to fill in the Reactome User Survey, let us know what matters most to you and how we can serve you better.

SURVEY

Pathway Browser

Visualize and interact with Reactome biological pathways

Analysis Tools

Merges pathway identifier mapping,
over-representation, and expression analysis

ReactomeFIViz

Designed to find pathways and network patterns related to cancer and other types of diseases

Documentation

Information to browse the database and use its principal tools for data analysis

Reactome Research Spotlight

[November 1, 2024] In PLOS Computational Biology, Wieder et al. (2024) employ the Reactome database and PathIntegrate, a pathway-based multi-omics integration tool based on single-sample pathway analysis and machine learning, to translate multi-omics datasets from molecular abundance measurements to pathway activity scores, enabling integration of disparate types of omics data according to a common scale. PathIntegrate provides higher sensitivity at low signal levels and efficiently identifies perturbed pathways from multi-omics datasets in COVID-19 and chronic obstructive pulmonary disease (COPD) examples, providing a readily interpretable predictive model.

ARCHIVE

Why Reactome

Reactome is a free, open-source, curated and peer-reviewed pathway database. Our goal is to provide intuitive bioinformatics tools for the visualization, interpretation and analysis of pathway knowledge to support basic research, genome analysis, modeling, systems biology and education. 

European Bioinformatics Institute (EMBL-EBI)
NYU Langone Health
Oregon Health & Science University
Ontario Institute for Cancer Research

The development of Reactome is supported by grants from the US National Institutes of Health (U24 HG012198) and the European Molecular Biology Laboratory.

Version 90 released on October 2, 2024

2,742

Human Pathways

15,492

Reactions

11,506

Proteins

2,053

Small Molecules

1,057

Drugs

39,318

Literature References

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