Find Reactions, Proteins and Pathways
Pathway Browser
Visualize and interact with Reactome biological pathways
Analysis Tools
Merges pathway identifier mapping,
over-representation, and expression analysis
AI Chatbot
Meet the React-to-Me AI Chatbot! Designed to answer your questions about Reactome Pathways.
ReactomeFIViz
Designed to find pathways and network patterns related to cancer and other types of diseases
Documentation
Information to browse the database and use its principal tools for data analysis
Reactome Research Spotlight
In their October 2025 Nature article “Reprogramming neuroblastoma by diet-enhanced polyamine depletion”, Cherkaoui et al. perform a novel enrichment analysis of codons in genes that encode components of Reactome pathways in order to elucidate the mechanism of the therapeutic effect of polyamine reduction on MYCN-driven neuroblastoma. With lower levels of polyamines, translation tended to stall preferentially at codons with adenosine at the third position, and enrichment of these codons is observed in the cell cycle pathway compared with the neuronal system pathway, accounting for the ability of translational stalling at these codons to specifically inhibit cell proliferation.
Why Reactome
Reactome is a free, open-source, curated and peer-reviewed pathway database. Our goal is to provide intuitive bioinformatics tools for the visualization, interpretation and analysis of pathway knowledge to support basic research, genome analysis, modeling, systems biology and education.
The development of Reactome is supported by grants from the US National Institutes of Health (U24 HG012198) and the European Molecular Biology Laboratory.
Version 94 released on September 17, 2025
Human Pathways
Reactions
Proteins
Small Molecules
Drugs
Literature References
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