Find Reactions, Proteins and Pathways
Pathway Browser
Visualize and interact with Reactome biological pathways
Analysis Tools
Merges pathway identifier mapping,
over-representation, and expression analysis
ReactomeFIViz
Designed to find pathways and network patterns related to cancer and other types of diseases
Documentation
Information to browse the database and use its principal tools for data analysis
Reactome Research Spotlight
With current treatments, focal segmental glomerulosclerosis (FSGS), the largest cause of nephrotic syndrome, frequently progresses to end stage kidney disease. Gebeshuber et al. in the September 2023 issue of Translational Research assembled 376 FSGS-associated proteins into a FSGS pathophysiology model, major components of which were Reactome pathways for Signal transduction and Hemostasis. The 39 proteins shared between FSGS model and a 102-protein model for the antiplatelet drug clopidogrel included 20 therapeutic targets of the drug. Tested in a FSGS mouse model, clopidogrel significantly attenuated disease severity, repositioning the drug as an attractive candidate for human clinical trials for FSGS.
Why Reactome
Reactome is a free, open-source, curated and peer-reviewed pathway database. Our goal is to provide intuitive bioinformatics tools for the visualization, interpretation and analysis of pathway knowledge to support basic research, genome analysis, modeling, systems biology and education.
The development of Reactome is supported by grants from the US National Institutes of Health (U24 HG012198) and the European Molecular Biology Laboratory.
Version 86 released on September 13th, 2023
2,647
Human Pathways
14,803
Reactions
11,148
Proteins
2,025
Small Molecules
1,119
Drugs
37,156
Literature References
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