Reactome | BAG5 [cytosol]

BAG5 [cytosol]

Stable Identifier

R-HSA-5255453

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

BAG family molecular chaperone regulator 5, BAG5_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to heat stress (Homo sapiens)
    - Regulation of HSF1-mediated heat shock response (Homo sapiens)
      - HSP110s exchange ATP for ADP on HSP70s:ADP (Homo sapiens)
        
        HSP70 NEFs [cytosol] (Homo sapiens)
        
        BAG1-5 [cytosol] (Homo sapiens)
        
        BAG5 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UL15 BAG5

Gene Names

BAG5, KIAA0873

Chain

chain:1-447

Reference Genes

BioGPS Gene:9529 BAG5

COSMIC (genes):BAG5 BAG5

CTD Gene:9529 BAG5

dbSNP Gene:9529 BAG5

ENSEMBL:ENSG00000166170 BAG5

ENSEMBL_homo_sapiens_GENE:ENSG00000166170.12 BAG5

HGNC:941 BAG5

KEGG Gene (Homo sapiens):9529 BAG5

Monarch:9529 BAG5

NCBI Gene:9529 BAG5

OMIM:603885 BAG5

UCSC:Q9UL15 BAG5

Reference Transcript

Other Identifiers

11733914_a_at

11739188_a_at

11742885_a_at

11742886_s_at

11742887_a_at

16797014

202984_PM_s_at

202984_s_at

202985_PM_s_at

202985_s_at

230427_3p_s_at

230427_PM_s_at

230427_s_at

3470416

3580792

3580793

3580794

3580795

3580796

3580797

3580798

3580799

36463_at

57702_at

7896045

7981439

9529

A_23_P37076

A_24_P130026

A_24_P82094

GE58349

GO:0000774

GO:0005515

GO:0005634

GO:0005737

GO:0005739

GO:0005829

GO:0006457

GO:0007030

GO:0010977

GO:0012501

GO:0016020

GO:0016234

GO:0019901

GO:0023052

GO:0030154

GO:0030163

GO:0030314

GO:0031397

GO:0031625

GO:0032435

GO:0036211

GO:0043226

GO:0048471

GO:0048856

GO:0050821

GO:0051087

GO:0051438

GO:0051444

GO:0061084

GO:0090083

GO:0098772

GO:1902176

HMNXSV003028425

Hs.5443.0.S1_3p_a_at

Hs.71436.0.A1_3p_at

Hs.71436.0.A1_3p_s_at

Hs.71436.0.A1_3p_x_at

ILMN_1728514

ILMN_1751396

ILMN_2361695

PH_hs_0000561

TC14001539.hg

g6631076_3p_a_at

Participates

as a member of

BAG1-5 [cytosol] (Homo sapiens)

Inferred To

Bag5 [cytosol] (Mus musculus)

Bag5 [cytosol] (Rattus norvegicus)

bag102 [cytosol] (Schizosaccharomyces pombe)

BAG5 [cytosol] (Canis familiaris)

BAG5 [cytosol] (Sus scrofa)

bag5 [cytosol] (Xenopus tropicalis)

Homologues of BAG5 [cytosol] (Schizosaccharomyces pombe)

bag101 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_004864.1, NP_001015048.1, NP_001015049.1

OpenTargets

ENSG00000166170

GeneCards

Q9UL15

HPA

ENSG00000166170-BAG5

Ensembl

ENSP00000299204, ENST00000445922, ENST00000299204, ENSP00000391713, ENSG00000166170, ENST00000337322, ENSP00000338814

PRO

Q9UL15

Pharos - Targets

Q9UL15

PDB

2D9D, 3A8Y

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.832	9
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.718	6
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.718	12
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.671	9
UniProt:Q8N9N5 BANP	1	BANP [nucleoplasm] (R-HSA-3221973)	0.556	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.527	4
UniProt:P0DTD2 9b	3	p-S53-9b [cytosol] (R-COV-9758478) 9b [cytosol] (R-COV-9694649) 9b [mitochondrial outer membrane] (R-COV-9709803)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	8

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