Reactome | DSP [ficolin-1-rich granule membrane]

DSP [ficolin-1-rich granule membrane]

Stable Identifier

R-HSA-6801396

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ficolin-1-rich granule membrane

Synonyms

Desmoplakin

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P15924 DSP

Gene Names

DSP

Chain

chain:1-2871

Reference Genes

BioGPS Gene:1832 DSP

COSMIC (genes):DSP DSP

CTD Gene:1832 DSP

dbSNP Gene:1832 DSP

ENSEMBL:ENSG00000096696 DSP

ENSEMBL:ENSG00000096696.15 DSP

HGNC:3052 DSP

KEGG Gene (Homo sapiens):1832 DSP

Monarch:1832 DSP

NCBI Gene:1832 DSP

OMIM:125647 DSP

UCSC:P15924 DSP

Reference Transcript

Other Identifiers

11739501_a_at

11757507_s_at

17004612

1832

200606_PM_at

200606_at

2893795

2893796

2893797

2893800

2893801

2893802

2893804

2893807

2893808

2893809

2893810

2893811

2893812

2893813

2893814

2893815

2893816

2893817

2893818

2893819

2893820

2893821

2893822

2893823

2893824

2893825

2893826

2893827

2893828

2893829

2893830

2893831

2893832

2893833

2893834

2893835

2893836

2893837

2893838

2893839

2893840

36133_at

8116780

A_32_P157945

A_33_P3402565

GE56076

GO:0001533

GO:0002934

GO:0003012

GO:0003013

GO:0003223

GO:0003723

GO:0005080

GO:0005198

GO:0005200

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005856

GO:0005882

GO:0005886

GO:0005911

GO:0005912

GO:0005916

GO:0007010

GO:0007155

GO:0008544

GO:0014704

GO:0016020

GO:0016323

GO:0018149

GO:0023052

GO:0030057

GO:0030154

GO:0030216

GO:0031410

GO:0034330

GO:0034332

GO:0036211

GO:0042060

GO:0043226

GO:0043588

GO:0045104

GO:0045109

GO:0048856

GO:0070062

GO:0070161

GO:0086073

GO:0086083

GO:0086091

GO:0090136

GO:0097110

GO:0098609

GO:0098631

GO:0098911

GO:0101003

GO:0110165

GO:0150105

HMNXSV003057465

ILMN_1655614

ILMN_1659749

ILMN_1677032

PH_hs_0032773

TC06000060.hg

g4758199_3p_at

g4758199_3p_s_at

Participates

as a member of

Ficolin-rich granule membrane proteins [ficolin-1-rich granule membrane] (Homo sapiens)

Other forms of this molecule

DSP [cornified envelope]

DSP(?-?) [plasma membrane]

DSP [plasma membrane]

Inferred To

dsp [ficolin-1-rich granule membrane] (Xenopus tropicalis)

shot [ficolin-1-rich granule membrane] (Drosophila melanogaster)

DSP [ficolin-1-rich granule membrane] (Bos taurus)

DSP [ficolin-1-rich granule membrane] (Canis familiaris)

DSP [ficolin-1-rich granule membrane] (Danio rerio)

DSP [ficolin-1-rich granule membrane] (Gallus gallus)

DSP [ficolin-1-rich granule membrane] (Sus scrofa)

Dsp [ficolin-1-rich granule membrane] (Mus musculus)

Dsp [ficolin-1-rich granule membrane] (Rattus norvegicus)

vab-10 [ficolin-1-rich granule membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001305963.1, NP_004406.2, NP_001008844.1

OpenTargets

ENSG00000096696

GeneCards

P15924

HPA

ENSG00000096696-DSP

Ensembl

ENST00000379802, ENST00000418664, ENSP00000369129, ENSG00000096696, ENSP00000396591

PRO

P15924

Pharos - Targets

P15924

Orphanet

15895

PDB

3R6N, 1LM5, 5DZZ, 1LM7

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.626	7
UniProt:P14923 JUP	6	JUP [cytosol] (R-HSA-201598) JUP [cornified envelope] (R-HSA-8847739) JUP [specific granule lumen] (R-HSA-6799534) JUP [extracellular region] (R-HSA-6806309) JUP [ficolin-1-rich granule lumen] (R-HSA-6801028) JUP [plasma membrane] (R-HSA-437260)	0.573	3
UniProt:P07332 FES	1	FES [cytosol] (R-HSA-396937)	0.564	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	10
UniProt:Q76353 Q76353			0.462	2

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