Reactome | KCNN4 [plasma membrane]

KCNN4 [plasma membrane]

Stable Identifier

R-HSA-977543

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Intermediate conductance calcium-activated potassium channel protein 4, KCNN4_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O15554 KCNN4

Gene Names

KCNN4, IK1, IKCA1, KCA4, SK4

Chain

chain:1-427

Reference Genes

BioGPS Gene:3783 KCNN4

COSMIC (genes):KCNN4 KCNN4

CTD Gene:3783 KCNN4

dbSNP Gene:3783 KCNN4

ENSEMBL:ENSG00000104783 KCNN4

ENSEMBL_homo_sapiens_GENE:ENSG00000104783.15 KCNN4

HGNC:6293 KCNN4

KEGG Gene (Homo sapiens):3783 KCNN4

Monarch:3783 KCNN4

NCBI Gene:3783 KCNN4

OMIM:602754 KCNN4

UCSC:O15554 KCNN4

Reference Transcript

RefSeq:NM_002250.2 KCNN4

Other Identifiers

11719227_x_at

11763785_x_at

11763806_x_at

16873087

204401_PM_at

204401_at

3783

3864647

3864648

3864649

3864650

3864651

3864654

3864656

3864659

3864660

3864661

3864665

3864666

3864667

3864668

3864669

3864670

3864671

3864674

3864675

3864676

41106_at

8037408

A_23_P67529

GE54173

GO:0002376

GO:0005215

GO:0005267

GO:0005515

GO:0005516

GO:0005829

GO:0005886

GO:0006811

GO:0006813

GO:0006816

GO:0006884

GO:0006952

GO:0008076

GO:0015269

GO:0016020

GO:0016286

GO:0019903

GO:0022600

GO:0022894

GO:0023052

GO:0030322

GO:0031982

GO:0034220

GO:0043005

GO:0043025

GO:0043226

GO:0045332

GO:0046541

GO:0050714

GO:0050862

GO:0051649

GO:0055085

GO:0061024

GO:0071805

GO:1901381

HMNXSV003032397

ILMN_1709937

PH_hs_0030982

TC19001595.hg

g4504858_3p_at

Inferred To

kcnl-1 [plasma membrane] (Caenorhabditis elegans)

kcnn4 [plasma membrane] (Xenopus tropicalis)

kcnl-4 [plasma membrane] (Caenorhabditis elegans)

Homologues of KCNN4 [plasma membrane] (Caenorhabditis elegans)

kcnl-3 [plasma membrane] (Caenorhabditis elegans)

kcnl-2 [plasma membrane] (Caenorhabditis elegans)

SK [plasma membrane] (Drosophila melanogaster)

Kcnn4 [plasma membrane] (Mus musculus)

Kcnn4 [plasma membrane] (Rattus norvegicus)

KCNN4 [plasma membrane] (Canis familiaris)

KCNN4 [plasma membrane] (Dictyostelium discoideum)

KCNN4 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_002241.1

ZINC - World Drugs

KCNN4_HUMAN

Guide to Pharmacology - Targets

384

OpenTargets

ENSG00000104783

ZINC - FDA approved

KCNN4_HUMAN

ZINC - Substances

KCNN4_HUMAN

ZINC target

O15554

PRO

O15554

PDB

6CNN, 6CNO, 6D42, 6CNM

ZINC - Investigational

KCNN4_HUMAN

HPA

ENSG00000104783-KCNN4

GeneCards

O15554

Ensembl

ENST00000648319, ENSG00000104783, ENSP00000496939

Pharos - Targets

O15554

Orphanet

23430

ZINC - Predictions - Purchasable

KCNN4_HUMAN

HMDB Protein

HMDBP07760

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.602	5
UniProt:P62158 CALM			0.587	2
UniProt:P61266 STX1B	3	STX1B(1-?) [cytosol] (R-HSA-5246520) STX1B(?-288) [plasma membrane] (R-HSA-5246519) STX1B [plasma membrane] (R-HSA-181479)	0.556	3
UniProt:Q8TDT2 GP152			0.556	3
UniProt:Q8TBE1 CNIH3	3	CNIH3 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689785) CNIH3 [ER to Golgi transport vesicle membrane] (R-HSA-5689783) CNIH3 [endoplasmic reticulum membrane] (R-HSA-5689443)	0.556	3
UniProt:Q14802-3 FXYD3			0.556	3
UniProt:Q13323 BIK			0.556	3
UniProt:Q01453 PMP22	1	PMP22 [plasma membrane] (R-HSA-9615623)	0.556	3
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.556	3

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