Reactome | UQCRC2 [mitochondrial inner membrane]

UQCRC2 [mitochondrial inner membrane]

Stable Identifier

R-HSA-164280

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Ubiquinol-cytochrome-c reductase complex core protein II, Complex III core protein II

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P22695 UQCRC2

Gene Names

UQCRC2

Chain

transit peptide:1-14, chain:15-453

Reference Genes

BioGPS Gene:7385 UQCRC2

COSMIC (genes):UQCRC2 UQCRC2

CTD Gene:7385 UQCRC2

dbSNP Gene:7385 UQCRC2

ENSEMBL:ENSG00000140740 UQCRC2

HGNC:12586 UQCRC2

KEGG:hsa:7385 UQCRC2

Monarch:7385 UQCRC2

NCBI Gene:7385 UQCRC2

OMIM:191329 UQCRC2

UCSC:P22695 UQCRC2

Reference Transcript

RefSeq:NM_003366.3 UQCRC2

Other Identifiers

11744059_a_at

11744060_s_at

16816739

200883_PM_at

200883_at

212600_PM_s_at

212600_s_at

239465_PM_at

239465_at

241755_PM_at

241755_at

3652230

3652231

3652233

3652234

3652235

3652236

3652237

3652238

3652239

3652240

3652241

3652242

3652243

3652244

3652245

3652246

3652248

3652249

3652250

3652252

3652253

3652257

3652258

3652260

3652261

3652262

40854_at

43661_at

7385

7993872

A_14_P124516

A_23_P118002

GE57520

GE86494

GO:0003824

GO:0004222

GO:0005515

GO:0005654

GO:0005739

GO:0005743

GO:0006091

GO:0006119

GO:0006122

GO:0006508

GO:0009060

GO:0016787

GO:0043226

GO:0045275

GO:0045333

GO:0046872

GO:0140096

HMNXSV003055371

Hs.173554.1.A1_3p_a_at

Hs.265591.1.A1_3p_at

ILMN_1718853

J04973_at

PH_hs_0010402

PH_hs_0040405

TC16000239.hg

Participates

as a member of

Substrate of LONP1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)

as an input of

Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH (Homo sapiens)

as a component of

Inferred To

MAS2 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

mppA1 [mitochondrial inner membrane] (Dictyostelium discoideum)

UQCRC2 [mitochondrial inner membrane] (Bos taurus)

UQCRC2 [mitochondrial inner membrane] (Canis familiaris)

UQCRC2 [mitochondrial inner membrane] (Gallus gallus)

UQCRC2 [mitochondrial inner membrane] (Sus scrofa)

mppA2 [mitochondrial inner membrane] (Dictyostelium discoideum)

uqcrc2b [mitochondrial inner membrane] (Danio rerio)

mas2 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

Uqcrc2 [mitochondrial inner membrane] (Mus musculus)

Uqcrc2 [mitochondrial inner membrane] (Rattus norvegicus)

UQCR-C2 [mitochondrial inner membrane] (Drosophila melanogaster)

Homologues of UQCRC2 [mitochondrial inner membrane] (Dictyostelium discoideum)

ucr-2.1 [mitochondrial inner membrane] (Caenorhabditis elegans)

Cross References

ENSEMBL

ENST00000268379, ENSP00000268379, ENSG00000140740

OpenTargets

ENSG00000140740

GeneCards

UQCRC2

HPA

ENSG00000140740-UQCRC2

PRO

P22695

Pharos - Targets

P22695

GlyGen

P22695

Orphanet

UQCRC2

HMDB Protein

HMDBP00985

PDB

5XTE, 5XTI, 5XTH

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31930 UQCRC1	1	UQCRC1 [mitochondrial inner membrane] (R-HSA-164284)	0.688	4
UniProt:Q8N7T0 Q8N7T0			0.556	3
UniProt:Q9H2C1 LHX5			0.556	3
UniProt:Q15027 ACAP1			0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:P07919 UQCRH	1	UQCRH [mitochondrial inner membrane] (R-HSA-164286)	0.527	2
UniProt:O14949 UQCRQ	1	UQCRQ [mitochondrial inner membrane] (R-HSA-164283)	0.527	2
UniProt:P14927 UQCRB	1	UQCRB [mitochondrial inner membrane] (R-HSA-164287)	0.527	3
UniProt:O00555 CACNA1A	1	CACNA1A [plasma membrane] (R-HSA-210490)	0.508	2
UniProt:P27105 STOM	4	STOM [tertiary granule membrane] (R-HSA-6800960) STOM [plasma membrane] (R-HSA-6806258) STOM [specific granule membrane] (R-HSA-6799569) STOM [azurophil granule membrane] (R-HSA-6800997)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12
UniProt:P13073 COX4I1	2	COX4I1 [mitochondrial intermembrane space] (R-HSA-9865413) COX4I1 [mitochondrial inner membrane] (R-HSA-164305)	0.483	2
UniProt:A0A096LP01 SIM26			0.462	3

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