Reactome | UQCRC2 [mitochondrial inner membrane]

UQCRC2 [mitochondrial inner membrane]

Stable Identifier

R-HSA-164280

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Ubiquinol-cytochrome-c reductase complex core protein II, Complex III core protein II

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P22695 UQCRC2

Gene Names

UQCRC2

Chain

transit peptide:1-14, chain:15-453

Reference Genes

BioGPS Gene:7385 UQCRC2

COSMIC (genes):UQCRC2 UQCRC2

CTD Gene:7385 UQCRC2

dbSNP Gene:7385 UQCRC2

ENSEMBL:ENSG00000140740 UQCRC2

ENSEMBL_homo_sapiens_GENE:ENSG00000140740.11 UQCRC2

HGNC:12586 UQCRC2

KEGG Gene (Homo sapiens):7385 UQCRC2

Monarch:7385 UQCRC2

NCBI Gene:7385 UQCRC2

OMIM:191329 UQCRC2

UCSC:P22695 UQCRC2

Reference Transcript

RefSeq:NM_003366.3 UQCRC2

Other Identifiers

11744059_a_at

11744060_s_at

16816739

200883_PM_at

200883_at

212600_PM_s_at

212600_s_at

3652231

3652233

3652234

3652235

3652239

3652241

3652242

3652243

3652246

3652248

3652249

3652250

3652252

3652258

3652260

3652261

3652262

40854_at

7385

7993872

A_23_P118002

GE57520

GO:0003824

GO:0004222

GO:0005515

GO:0005634

GO:0005654

GO:0005739

GO:0005743

GO:0005750

GO:0005751

GO:0006091

GO:0006119

GO:0006122

GO:0006508

GO:0009060

GO:0016020

GO:0016787

GO:0043226

GO:0045333

GO:0046872

GO:0070469

GO:0140096

HMNXSV003055371

Hs.173554.1.A1_3p_a_at

ILMN_1718853

J04973_at

PH_hs_0010402

TC16000239.hg

Participates

as a member of

Substrate of LONP1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)

as a component of

Ubiquinol-cytochrome c reductase [mitochondrial inner membrane] (Homo sapiens)

Inferred To

MAS2 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

mppA1 [mitochondrial inner membrane] (Dictyostelium discoideum)

UQCRC2 [mitochondrial inner membrane] (Bos taurus)

UQCRC2 [mitochondrial inner membrane] (Canis familiaris)

UQCRC2 [mitochondrial inner membrane] (Gallus gallus)

UQCRC2 [mitochondrial inner membrane] (Sus scrofa)

mppA2 [mitochondrial inner membrane] (Dictyostelium discoideum)

mas2 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

Uqcrc2 [mitochondrial inner membrane] (Mus musculus)

Uqcrc2 [mitochondrial inner membrane] (Rattus norvegicus)

UQCR-C2 [mitochondrial inner membrane] (Drosophila melanogaster)

Homologues of UQCRC2 [mitochondrial inner membrane] (Dictyostelium discoideum)

ucr-2.1 [mitochondrial inner membrane] (Caenorhabditis elegans)

uqcrc2 [mitochondrial inner membrane] (Danio rerio)

Cross References

RefSeq

NP_003357.2

OpenTargets

ENSG00000140740

HPA

ENSG00000140740-UQCRC2

GeneCards

P22695

Ensembl

ENST00000268379, ENSG00000140740, ENSP00000268379

PRO

P22695

Pharos - Targets

P22695

Orphanet

21895

HMDB Protein

HMDBP00985

PDB

5XTH, 5XTI, 5XTE

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12

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