Reactome | UQCRC2 [mitochondrial inner membrane]

UQCRC2 [mitochondrial inner membrane]

Stable Identifier

R-HSA-164280

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Ubiquinol-cytochrome-c reductase complex core protein II, Complex III core protein II

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P22695 UQCRC2

Gene Names

UQCRC2

Chain

transit peptide:1-14, chain:15-453

Reference Genes

BioGPS Gene:7385 UQCRC2

COSMIC (genes):UQCRC2 UQCRC2

CTD Gene:7385 UQCRC2

dbSNP Gene:7385 UQCRC2

ENSEMBL:ENSG00000140740 UQCRC2

HGNC:12586 UQCRC2

KEGG:hsa:7385 UQCRC2

Monarch:7385 UQCRC2

NCBI Gene:7385 UQCRC2

OMIM:191329 UQCRC2

UCSC:P22695 UQCRC2

Reference Transcript

RefSeq:NM_003366.4 UQCRC2

Other Identifiers

11744059_a_at

11744060_s_at

16816739

200883_PM_at

200883_at

212600_PM_s_at

212600_s_at

239465_PM_at

239465_at

241755_PM_at

241755_at

3652228

3652230

3652231

3652233

3652234

3652235

3652236

3652237

3652238

3652239

3652240

3652241

3652242

3652243

3652244

3652245

3652246

3652248

3652249

3652250

3652252

3652253

3652255

3652256

3652257

3652258

3652260

3652261

3652262

40854_at

7385

7993872

A_14_P124516

A_23_P118002

GE57520

GE86494

GO:0004222

GO:0005515

GO:0005654

GO:0005739

GO:0005743

GO:0006091

GO:0006119

GO:0006122

GO:0006508

GO:0009060

GO:0016020

GO:0045275

GO:0045333

GO:0046872

HMNXSV003055371

Hs.173554.1.A1_3p_a_at

Hs.265591.1.A1_3p_at

ILMN_1718853

J04973_at

PH_hs_0010402

PH_hs_0040405

TC16000239.hg

Participates

as a member of

Substrate of LONP1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)

as an input of

Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH (Homo sapiens)

as a component of

Inferred To

MAS2 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

mppA1 [mitochondrial inner membrane] (Dictyostelium discoideum)

UQCRC2 [mitochondrial inner membrane] (Bos taurus)

UQCRC2 [mitochondrial inner membrane] (Canis familiaris)

UQCRC2 [mitochondrial inner membrane] (Gallus gallus)

UQCRC2 [mitochondrial inner membrane] (Sus scrofa)

mppA2 [mitochondrial inner membrane] (Dictyostelium discoideum)

uqcrc2b [mitochondrial inner membrane] (Danio rerio)

mas2 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

Uqcrc2 [mitochondrial inner membrane] (Mus musculus)

Uqcrc2 [mitochondrial inner membrane] (Rattus norvegicus)

UQCR-C2 [mitochondrial inner membrane] (Drosophila melanogaster)

Homologues of UQCRC2 [mitochondrial inner membrane] (Dictyostelium discoideum)

ucr-2.1 [mitochondrial inner membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_003357.2

ENSEMBL

ENSP00000268379, ENSG00000140740, ENST00000268379

OpenTargets

ENSG00000140740

GeneCards

UQCRC2

HPA

ENSG00000140740-UQCRC2

PRO

P22695

Pharos - Targets

P22695

GlyGen

P22695

Orphanet

UQCRC2

HMDB Protein

HMDBP00985

PDB

5XTE, 5XTI, 5XTH

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31930 UQCRC1	1	UQCRC1 [mitochondrial inner membrane] (R-HSA-164284)	0.688	4
UniProt:P14927 UQCRB	1	UQCRB [mitochondrial inner membrane] (R-HSA-164287)	0.643	4
UniProt:P07919 UQCRH	1	UQCRH [mitochondrial inner membrane] (R-HSA-164286)	0.643	3
UniProt:O14949 UQCRQ	1	UQCRQ [mitochondrial inner membrane] (R-HSA-164283)	0.643	3
UniProt:Q8N7T0 Q8N7T0			0.556	3
UniProt:Q9H2C1 LHX5			0.556	3
UniProt:Q15027 ACAP1			0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:O00555 CACNA1A	1	CACNA1A [plasma membrane] (R-HSA-210490)	0.508	2
UniProt:P27105 STOM	4	STOM [specific granule membrane] (R-HSA-6799569) STOM [plasma membrane] (R-HSA-6806258) STOM [azurophil granule membrane] (R-HSA-6800997) STOM [tertiary granule membrane] (R-HSA-6800960)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	12
UniProt:P13073 COX4I1	2	COX4I1 [mitochondrial inner membrane] (R-HSA-164305) COX4I1 [mitochondrial intermembrane space] (R-HSA-9865413)	0.483	2
UniProt:A0A096LP01 SIM26			0.462	3

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