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KLHL22 [cytosol]
Stable Identifier
R-HSA-8863210
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Kelch-like protein 22, KLH22_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL22 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL22 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL22 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL22 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL22 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL22 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL22 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL22 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL22 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL22 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL22 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL22 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL22 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL22 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL22 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL22 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q53GT1 KLHL22
Gene Names
KLHL22
Chain
initiator methionine:1, chain:2-634
Reference Genes
BioGPS Gene:84861 KLHL22
COSMIC (genes):KLHL22 KLHL22
CTD Gene:84861 KLHL22
dbSNP Gene:84861 KLHL22
ENSEMBL:ENSG00000099910 KLHL22
HGNC:25888 KLHL22
KEGG Gene (Homo sapiens):84861 KLHL22
Monarch:84861 KLHL22
NCBI Gene:84861 KLHL22
OMIM:618020 KLHL22
UCSC:Q53GT1 KLHL22
Reference Transcript
RefSeq:NM_032775.3 KLHL22
RefSeq:XM_017029021.1 KLHL22
Other Identifiers
0001740494
11720778_a_at
11720779_a_at
16932584
221837_at
221838_at
3953557
3953558
3953559
3953560
3953562
3953563
3953568
3953571
3953574
3953586
3953587
3953594
40766
46177_at
4920776C_3p_x_at
49329_at
8074632
84861
A_23_P143580
A_24_P117323
AAH15923
AC007731
AK027266
AK222850
AK290669
AK294682
BAB55007
BAD96570
BAF83358
BAH11847
BC015923
C9J191
C9J2T1
C9J5F8
C9JHG1
C9JLE9
C9JRG9
CAG30238
CCDS13780
CH471176
CR456352
EAX02961
EAX02962
EAX02963
ENSG00000099910
ENSP00000331682
ENST00000328879
ENST00000328879.8
EntrezGene:84861
EntrezGene:KLHL22
GE83514
GE88716
GO:0000070
GO:0000278
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005764
GO:0005773
GO:0005813
GO:0005815
GO:0005819
GO:0005827
GO:0005829
GO:0005856
GO:0006464
GO:0006513
GO:0006914
GO:0007049
GO:0007059
GO:0007094
GO:0007165
GO:0008150
GO:0009056
GO:0010507
GO:0016567
GO:0030307
GO:0031463
GO:0032991
GO:0040007
GO:0043161
GO:0043226
GO:0043687
GO:0051276
GO:0051301
GO:0071230
GO:0071233
GO:0071889
GO:0072686
GO:0140014
GO:1904263
HGNC:25888
HPA040766
Hs.181341.1.A1_3p_at
Hs.181341.1.A2_3p_s_at
ILMN_1705390
IPR000210
IPR006652
IPR011333
IPR011705
IPR015915
IPR017096
IPR030575
KLHL22
KLHL22-201
MIM:618020
NM_032775
NP_116164
NR_033825
PF00651
PF01344
PF07707
PF13415
PF13964
PH_hs_0023940
SM00225
SM00612
SM00875
TC22001224.hg
TC22001484.hg
UPI0000072F37
XM_017029018
XM_017029019
XM_017029020
XM_017029021
XM_017029022
XM_017029023
XM_017029024
XM_017029025
XP_016884507
XP_016884508
XP_016884509
XP_016884510
XP_016884511
XP_016884512
XP_016884513
XP_016884514
Participant Of
hasMember
BTB proteins [cytosol]
Inferred To
KLHL22 [cytosol] (Bos taurus)
KLHL22 [cytosol] (Danio rerio)
KLHL22 [cytosol] (Dictyostelium discoideum)
KLHL22 [cytosol] (Drosophila melanogaster)
KLHL22 [cytosol] (Gallus gallus)
KLHL22 [cytosol] (Mus musculus)
KLHL22 [cytosol] (Rattus norvegicus)
KLHL22 [cytosol] (Sus scrofa)
KLHL22 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
XP_016884510.1
,
NP_116164.2
OpenTargets
ENSG00000099910
GeneCards
Q53GT1
PRO
Q53GT1
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