Reactome | ELOB [cytosol]

ELOB [cytosol]

Stable Identifier

R-HSA-180551

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TCEB2, Transcription elongation factor B polypeptide 2, RNA polymerase II transcription factor SIII subunit B, SIII p18, Elongin-B, Elongin 18 kDa subunit

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to hypoxia (Homo sapiens)
    - Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
      - Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOB [cytosol] (Homo sapiens)
      - Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOB [cytosol] (Homo sapiens)
      - Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOB [cytosol] (Homo sapiens)
      - Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Homo sapiens)
        
        hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOB [cytosol] (Homo sapiens)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOB [cytosol] (Homo sapiens)
      - Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOB [cytosol] (Homo sapiens)
        
        hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOB [cytosol] (Homo sapiens)
      - Proteasome proteolyzes ub-HIF-alpha (Homo sapiens)
        
        VBC complex (with or without LIMD1) [cytosol] (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOB [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOB [cytosol] (Homo sapiens)
        
        ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Homo sapiens)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOB [cytosol] (Homo sapiens)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOB [cytosol] (Homo sapiens)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Homo sapiens)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOB [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15370 ELOB

Gene Names

ELOB, TCEB2

Chain

chain:1-118

Reference Genes

BioGPS Gene:6923 ELOB

COSMIC (genes):ELOB ELOB

CTD Gene:6923 ELOB

dbSNP Gene:6923 ELOB

ENSEMBL:ENSG00000103363.16 ELOB

HGNC:11619 ELOB

KEGG Gene (Homo sapiens):6923 ELOB

Monarch:6923 ELOB

NCBI Gene:6923 ELOB

OMIM:600787 ELOB

UCSC:Q15370 ELOB

Reference Transcript

Other Identifiers

0001660711

11716607_a_at

16823193

18671099

18671100

18671101

18671102

18671103

18671105

200085_PM_s_at

200085_s_at

213877_PM_x_at

213877_x_at

3506227

3677165

3677166

3677167

3677168

3677169

3677170

3677172

3677173

3677175

3677176

3677178

39184_at

6923

7892995

7893217

7893454

7893481

7895604

7895832

7895908

7895933

7896472

7998852

A_23_P100392

A_23_P312181

GE554817

GE61523

GO:0001222

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006367

GO:0006368

GO:0016567

GO:0030163

GO:0030891

GO:0031462

GO:0031466

GO:0031625

GO:0032436

GO:0032991

GO:0036211

GO:0043226

GO:0065003

GO:0070449

HMNXSV003018932

HMNXSV003028757

Hs.172772.0.A1_3p_x_at

Hs.172772.2.A1_3p_a_at

ILMN_1733927

ILMN_2377185

PH_hs_0029324

TC16000791.hg

Participates

as an output of

SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Homo sapiens)

as a component of

as an input of

SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 (Homo sapiens)

Other forms of this molecule

TCEB2 [nucleoplasm]

Inferred To

TCEB2 [cytosol] (Bos taurus)

ELOB [cytosol] (Canis familiaris)

ELOB [cytosol] (Sus scrofa)

EloB [cytosol] (Drosophila melanogaster)

elob [cytosol] (Xenopus tropicalis)

Ghost homologue of ELOB [cytosol] (Danio rerio)

Ghost homologue of ELOB [cytosol] (Dictyostelium discoideum)

Ghost homologue of ELOB [cytosol] (Gallus gallus)

Elob [cytosol] (Mus musculus)

Elob [cytosol] (Rattus norvegicus)

elb-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_996896.1, NP_009039.1

OpenTargets

ENSG00000103363

HPA

ENSG00000103363-ELOB

GeneCards

Q15370

Ensembl

ENSP00000386652, ENSG00000103363, ENST00000409906, ENST00000262306, ENSP00000262306

PRO

Q15370

Pharos - Targets

Q15370

PDB

6R7I, 5T35, 2JZ3, 4W9G, 3ZKJ, 7CJB, 6GMX, 5NVZ, 5N4W, 6R7H, 6HAY, 3DCG, 5NVW, 6GFY, 6GMR, 6GFZ, 4W9F, 4W9L, 4W9K, 6HAX, 7KHH, 6FMI, 2IZV, 6I4X, 6GMQ, 7Q2J, 4AJY, 3ZRF, 4BKS, 4W9D, 6FMJ, 4N9F, 6I7Q, 6V9H, 7JTP, 6SIS, 7JTO, 4WQO, 5NVY, 5NW0, 4W9H, 7PLO, 1LM8, 7M6T, 2MA9, 7PI4, 5BO4, 6I5J, 5NW1, 4W9I, 4BKT, 6R7F, 4W9E, 6ZHC, 3ZTC, 6FMK, 5NVX, 3ZTD, 6C5X, 1LQB, 4AWJ, 3ZRC, 4B9K, 5NVV, 2C9W, 3ZUN, 3ZNG, 6I7R, 6GFX, 4B95, 5NW2, 6P59, 6R7N, 6GMN, 1VCB, 4W9J, 5LLI, 6HR2, 4W9C, 6BVB, 6I5N, 6R6H

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15369 ELOC	2	TCEB1 [nucleoplasm] (R-HSA-112422) ELOC [cytosol] (R-HSA-180535)	0.952	20
UniProt:P40337 VHL	3	monoSUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697) VHL [nucleoplasm] (R-HSA-1234127) VHL [cytosol] (R-HSA-391423)	0.928	11
UniProt:Q16665 HIF1A	7	HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.789	8
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.643	12
UniProt:Q13617 CUL2	3	G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511) CUL2 [cytosol] (R-HSA-416982) CUL2 [nucleoplasm] (R-HSA-1234126)	0.643	8
UniProt:A0A663DJA2 ORF10			0.643	3
UniProt:P12504 VIF			0.558	5
UniProt:Q96EL3 MRPL53	1	MRPL53 [mitochondrial inner membrane] (R-HSA-5368226)	0.556	5
UniProt:Q96G25 MED8	1	MED8 [nucleoplasm] (R-HSA-556784)	0.548	5
UniProt:P40337-3 VHL			0.547	2
UniProt:P78395 PRAME			0.532	4
UniProt:Q9NWX5 ASB6	1	ASB6 [cytosol] (R-HSA-975412)	0.527	3
UniProt:Q6PD62 CTR9	1	CTR9 [nucleoplasm] (R-HSA-8866694)	0.527	2
UniProt:Q96S21 RAB40C	2	GGC-RAB40C [cytosol] (R-HSA-8874025) RAB40C [cytosol] (R-HSA-8873693)	0.525	2

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