Reactome | ERLIN1 [endoplasmic reticulum membrane]

ERLIN1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-8866518

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Erlin-1, ERLN1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O75477 ERLIN1

Gene Names

ERLIN1, C10orf69, KE04, KEO4, SPFH1

Chain

chain:1-348

Reference Genes

BioGPS Gene:10613 ERLIN1

COSMIC (genes):ERLIN1 ERLIN1

CTD Gene:10613 ERLIN1

dbSNP Gene:10613 ERLIN1

ENSEMBL:ENSG00000107566 ERLIN1

ENSEMBL_homo_sapiens_GENE:ENSG00000107566.14 ERLIN1

HGNC:16947 ERLIN1

KEGG Gene (Homo sapiens):10613 ERLIN1

Monarch:10613 ERLIN1

NCBI Gene:10613 ERLIN1

OMIM:611604 ERLIN1

UCSC:O75477 ERLIN1

Reference Transcript

Other Identifiers

10613

11720444_s_at

11730914_a_at

11730915_a_at

16717452

202441_PM_at

202441_at

202444_PM_s_at

202444_s_at

3303271

3303272

3303274

3303276

3303279

3303281

3303284

3303285

3303286

3303287

3303289

3303292

3303293

3303294

3303295

3303296

36219_at

57042_at

7935692

A_23_P52219

GE54585

GO:0005515

GO:0005783

GO:0005789

GO:0006629

GO:0008202

GO:0008203

GO:0008289

GO:0015485

GO:0016020

GO:0023052

GO:0030163

GO:0030433

GO:0031625

GO:0032933

GO:0032991

GO:0043226

GO:0045121

GO:0045540

GO:0045541

GO:0045717

GO:0110165

HMNXSV003004179

Hs.285818.0.S2_3p_at

ILMN_1730731

PH_hs_0014786

PH_hs_0032500

PH_hs_0038770

TC10002930.hg

g5453705_3p_a_at

Participates

as a component of

ERLIN1:ERLIN2 [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

erlin1 [endoplasmic reticulum membrane] (Danio rerio)

erlin1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Erlin1 [endoplasmic reticulum membrane] (Mus musculus)

Erlin1 [endoplasmic reticulum membrane] (Rattus norvegicus)

ERLIN1 [endoplasmic reticulum membrane] (Bos taurus)

ERLIN1 [endoplasmic reticulum membrane] (Canis familiaris)

ERLIN1 [endoplasmic reticulum membrane] (Gallus gallus)

Ghost homologue of ERLIN1 [endoplasmic reticulum membrane] (Drosophila melanogaster)

Ghost homologue of ERLIN1 [endoplasmic reticulum membrane] (Sus scrofa)

erl-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001334788.1, NP_001334786.1, NP_006450.2, NP_001334790.1, NP_001094096.1, NP_001334789.1

OpenTargets

ENSG00000107566

HPA

ENSG00000107566-ERLIN1

GeneCards

O75477

Ensembl

ENST00000421367, ENST00000407654, ENSP00000384900, ENSG00000107566, ENSP00000410964

PRO

O75477

Pharos - Targets

O75477

Orphanet

22897

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q86TM6 SYVN1	1	SYVN1(1-617) [endoplasmic reticulum membrane] (R-HSA-535496)	0.564	2
UniProt:P15303	4	phospho-p-S738,T744 SEC23A [cytosol] (R-SCE-5685740) SEC23A [ER to Golgi transport vesicle membrane] (R-SCE-204024) SEC23A [cytosol] (R-SCE-203972) SEC23A [endoplasmic reticulum membrane] (R-SCE-203976)	0.556	3
UniProt:Q15436 SEC23A	4	p-S738,T744 SEC23A [cytosol] (R-HSA-5685740) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) SEC23A [cytosol] (R-HSA-203972) SEC23A [endoplasmic reticulum membrane] (R-HSA-203976)	0.556	3
UniProt:Q12982 BNIP2	1	BNIP2 [cytosol] (R-HSA-200792)	0.556	3
UniProt:Q7L5A8 FA2H	1	FA2H [endoplasmic reticulum membrane] (R-HSA-5693771)	0.556	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	9

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