Reactome | USP19 [cytosol]

USP19 [cytosol]

Stable Identifier

R-HSA-6781794

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin carboxyl-terminal hydrolase 19, UBP19_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O94966 USP19

Gene Names

USP19, KIAA0891, ZMYND9

Chain

chain:1-1318

Reference Genes

BioGPS Gene:10869 USP19

COSMIC (genes):USP19 USP19

CTD Gene:10869 USP19

dbSNP Gene:10869 USP19

ENSEMBL:ENSG00000172046 USP19

HGNC:12617 USP19

Monarch:10869 USP19

NCBI Gene:10869 USP19

OMIM:614471 USP19

UCSC:O94966 USP19

Reference Transcript

Other Identifiers

10869

11729873_a_at

11747495_a_at

11747496_x_at

11761972_a_at

16953906

214674_PM_at

214674_at

226357_PM_at

226357_at

2673995

2673997

2673999

2674000

2674001

2674002

2674003

2674004

2674005

2674007

2674008

2674009

2674010

2674011

2674012

2674013

2674014

2674015

2674016

2674017

2674018

2674019

2674020

2674021

2674022

2674023

2674024

2674025

2674026

2674027

2674028

2674029

2674030

2674031

2674032

2674033

2674034

2674035

2674036

2674037

2674038

2674039

2674040

2674044

2674045

2674046

2674048

38901_at

49521_at

8087308

A_23_P113789

A_33_P3338116

A_33_P3360301

GE53564

GO:0003824

GO:0004843

GO:0005515

GO:0005783

GO:0005789

GO:0005829

GO:0006508

GO:0008233

GO:0008234

GO:0016020

GO:0016579

GO:0016787

GO:0030163

GO:0031647

GO:0034976

GO:0036503

GO:0043226

GO:0046872

GO:0048642

GO:0050821

GO:0051879

GO:0090068

GO:0140096

GO:1900037

GO:1904292

HMNXSV003041695

HMNXSV003048478

HMNXSV003050736

Hs.301373.0.S1_3p_at

Hs.301373.1.S1_3p_at

ILMN_1718679

PH_hs_0032348

TC03001401.hg

Participates

as a component of

as an input of

USP19 binds HIF1A,BIRC2,BIRC3 (Homo sapiens)

Inferred To

DOA4 [cytosol] (Saccharomyces cerevisiae)

ubp12 [cytosol] (Schizosaccharomyces pombe)

ubp1 [cytosol] (Schizosaccharomyces pombe)

usp19 [cytosol] (Xenopus tropicalis)

Homologues of USP19 [cytosol] (Dictyostelium discoideum)

Homologues of USP19 [cytosol] (Plasmodium falciparum)

Homologues of USP19 [cytosol] (Saccharomyces cerevisiae)

Homologues of USP19 [cytosol] (Schizosaccharomyces pombe)

USP19 [cytosol] (Bos taurus)

USP19 [cytosol] (Caenorhabditis elegans)

USP19 [cytosol] (Canis familiaris)

USP19 [cytosol] (Dictyostelium discoideum)

USP19 [cytosol] (Gallus gallus)

USP19 [cytosol] (Mus musculus)

USP19 [cytosol] (Plasmodium falciparum)

USP19 [cytosol] (Rattus norvegicus)

USP19 [cytosol] (Sus scrofa)

UBP12 [cytosol] (Saccharomyces cerevisiae)

UBP5 [cytosol] (Saccharomyces cerevisiae)

Cross References

ENSEMBL

ENSP00000381863, ENST00000453664, ENST00000434032, ENSP00000400090, ENSP00000381870, ENST00000398888, ENSP00000395260, ENST00000417901, ENST00000398896, ENSP00000401197

OpenTargets

ENSG00000172046

HPA

ENSG00000172046-USP19

PRO

O94966

Pharos - Targets

O94966

GlyGen

O94966

PDB

4X3G, 6K7W, 6KQV, 1WH0, 6KHV

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9WMX2-PRO_0000037551			0.547	2
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.527	7
UniProt:O75344 FKBP6	2	FKBP6 [nucleoplasm] (R-HSA-912512) FKBP6 [cytosol] (R-HSA-5601923)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	6
UniProt:Q99IB8-PRO_0000045602			0.462	5

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