Reactome | SLC25A22 [mitochondrial inner membrane]

SLC25A22 [mitochondrial inner membrane]

Stable Identifier

R-HSA-5216091

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Mitochondrial glutamate carrier 1, GHC1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9H936 SLC25A22

Gene Names

SLC25A22, GC1

Chain

chain:1-323

Reference Genes

BioGPS Gene:79751 SLC25A22

COSMIC (genes):SLC25A22 SLC25A22

CTD Gene:79751 SLC25A22

dbSNP Gene:79751 SLC25A22

ENSEMBL:ENSG00000177542 SLC25A22

HGNC:19954 SLC25A22

KEGG:hsa:79751 SLC25A22

Monarch:79751 SLC25A22

NCBI Gene:79751 SLC25A22

OMIM:609302 SLC25A22

UCSC:Q9H936 SLC25A22

Reference Transcript

Other Identifiers

11718010_at

11724124_a_at

11747741_a_at

16734097

218725_PM_at

218725_at

219019_PM_at

219019_at

221640_PM_s_at

221640_s_at

3358400

3358402

3358403

3358404

3358405

3358406

3358407

3358408

3358409

3358410

3358411

3358412

3358413

3358414

3358415

3358416

3358418

3358419

3358420

3358421

3358422

3358423

3358424

3358426

3358427

3358428

3358429

3358430

3358431

3358432

52890_at

57583_at

7945539

79751

A_23_P409386

A_32_P117145

A_33_P3309319

GE62038

GO:0005280

GO:0005313

GO:0005739

GO:0005743

GO:0006811

GO:0015183

GO:0015293

GO:0015810

GO:0015813

GO:0016020

GO:0043490

GO:0050796

GO:0055085

GO:0070778

GO:1902600

HMNXSV003010873

HMNXSV003011559

ILMN_1687958

ILMN_2400352

ILMN_2406552

PH_hs_0005549

PH_hs_0020829

TC11001247.hg

g10130018_3p_a_at

g13375982_3p_at

g13375982_3p_x_at

g8923912_3p_x_at

Participates

as a member of

SLC25A18,A22 [mitochondrial inner membrane] (Homo sapiens)

Inferred To

slc-25a18.1 [mitochondrial inner membrane] (Caenorhabditis elegans)

Slc25a22 [mitochondrial inner membrane] (Mus musculus)

Slc25a22 [mitochondrial inner membrane] (Rattus norvegicus)

SLC25A22 [mitochondrial inner membrane] (Bos taurus)

SLC25A22 [mitochondrial inner membrane] (Canis familiaris)

SLC25A22 [mitochondrial inner membrane] (Gallus gallus)

SLC25A22 [mitochondrial inner membrane] (Sus scrofa)

GC1 [mitochondrial inner membrane] (Drosophila melanogaster)

mcfO [mitochondrial inner membrane] (Dictyostelium discoideum)

AGC1 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

slc25a22a [mitochondrial inner membrane] (Danio rerio)

Cross References

RefSeq

XP_011518671.1, NP_001412266.1, XP_054225941.1, XP_054225942.1, NP_001412267.1, XP_024304457.1, NP_001177990.1, XP_024304455.1, NP_001412268.1, XP_054225943.1, XP_054225935.1, XP_054225939.1, XP_054225937.1, XP_054225936.1, XP_047283556.1, XP_024304456.1, XP_047283555.1, XP_047283557.1, NP_001177989.1, NP_078974.1, XP_011518673.1, XP_011518672.1

Guide to Pharmacology - Targets

1058

OpenTargets

ENSG00000177542

ENSEMBL

ENSP00000437236, ENST00000320230, ENSP00000322020, ENSP00000486058, ENST00000628067, ENST00000531214, ENSG00000177542

HPA

ENSG00000177542-SLC25A22

GeneCards

SLC25A22

PRO

Q9H936

Pharos - Targets

Q9H936

Orphanet

SLC25A22

GlyGen

Q9H936

HMDB Protein

HMDBP07235

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	7

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