Reactome | SLC25A22 [mitochondrial inner membrane]

SLC25A22 [mitochondrial inner membrane]

Stable Identifier

R-HSA-5216091

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Mitochondrial glutamate carrier 1, GHC1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9H936 SLC25A22

Gene Names

SLC25A22, GC1

Chain

chain:1-323

Reference Genes

BioGPS Gene:79751 SLC25A22

COSMIC (genes):SLC25A22 SLC25A22

CTD Gene:79751 SLC25A22

dbSNP Gene:79751 SLC25A22

ENSEMBL:ENSG00000177542 SLC25A22

HGNC:19954 SLC25A22

KEGG:hsa:79751 SLC25A22

Monarch:79751 SLC25A22

NCBI Gene:79751 SLC25A22

OMIM:609302 SLC25A22

UCSC:Q9H936 SLC25A22

Reference Transcript

Other Identifiers

11718010_at

11747741_a_at

16734097

218725_PM_at

218725_at

3358400

3358402

3358403

3358404

3358405

3358406

3358407

3358408

3358409

3358410

3358411

3358412

3358413

3358414

3358415

3358416

3358418

3358419

3358420

3358422

3358423

3358424

52890_at

7945539

79751

A_23_P409386

GE62038

GO:0005215

GO:0005280

GO:0005313

GO:0005739

GO:0005743

GO:0006811

GO:0015183

GO:0015293

GO:0015810

GO:0015813

GO:0016020

GO:0043226

GO:0043490

GO:0050796

GO:0055085

GO:0070778

GO:1902600

HMNXSV003010873

ILMN_1687958

PH_hs_0005549

TC11001247.hg

g13375982_3p_at

g13375982_3p_x_at

Participates

as a member of

SLC25A18,A22 [mitochondrial inner membrane] (Homo sapiens)

Inferred To

slc-25a18.2 [mitochondrial inner membrane] (Caenorhabditis elegans)

slc-25a18.1 [mitochondrial inner membrane] (Caenorhabditis elegans)

Slc25a22 [mitochondrial inner membrane] (Mus musculus)

Slc25a22 [mitochondrial inner membrane] (Rattus norvegicus)

slc25a22l [mitochondrial inner membrane] (Xenopus tropicalis)

GC2 [mitochondrial inner membrane] (Drosophila melanogaster)

SLC25A22 [mitochondrial inner membrane] (Bos taurus)

SLC25A22 [mitochondrial inner membrane] (Canis familiaris)

SLC25A22 [mitochondrial inner membrane] (Dictyostelium discoideum)

SLC25A22 [mitochondrial inner membrane] (Gallus gallus)

SLC25A22 [mitochondrial inner membrane] (Sus scrofa)

GC1 [mitochondrial inner membrane] (Drosophila melanogaster)

AGC1 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

Homologues of SLC25A22 [mitochondrial inner membrane] (Caenorhabditis elegans)

Homologues of SLC25A22 [mitochondrial inner membrane] (Danio rerio)

Homologues of SLC25A22 [mitochondrial inner membrane] (Drosophila melanogaster)

slc25a55a [mitochondrial inner membrane] (Danio rerio)

slc25a55b [mitochondrial inner membrane] (Danio rerio)

Cross References

RefSeq

NP_001177990.1, XP_011518671.1, NP_078974.1, NP_001177989.1, XP_011518672.1, XP_011518673.1

Guide to Pharmacology - Targets

1058

ENSEMBL

ENST00000320230, ENSP00000322020, ENSP00000486058, ENST00000628067, ENST00000531214, ENSP00000437236

OpenTargets

ENSG00000177542

HPA

ENSG00000177542-SLC25A22

PRO

Q9H936

Pharos - Targets

Q9H936

GlyGen

Q9H936

Orphanet

SLC25A22

HMDB Protein

HMDBP07235

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7

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