Reactome | FEN1 [nucleoplasm]

FEN1 [nucleoplasm]

Stable Identifier

R-HSA-54745

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Flap endonuclease-1 , Maturation factor 1, MF1

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - S Phase (Homo sapiens)
    - Synthesis of DNA (Homo sapiens)
      - DNA strand elongation (Homo sapiens)
        
        Lagging Strand Synthesis (Homo sapiens)
        
        Processive synthesis on the lagging strand (Homo sapiens)
        
        Removal of the Flap Intermediate (Homo sapiens)
        
        Removal of remaining Flap (Homo sapiens)
        
        FEN1 [nucleoplasm] (Homo sapiens)
- Chromosome Maintenance (Homo sapiens)
  - Telomere Maintenance (Homo sapiens)
    - Extension of Telomeres (Homo sapiens)
      - Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
        
        Processive synthesis on the C-strand of the telomere (Homo sapiens)
        
        Removal of the Flap Intermediate from the C-strand (Homo sapiens)
        
        Removal of remaining Flap from the C-strand (Homo sapiens)
        
        FEN1 [nucleoplasm] (Homo sapiens)

DNA Replication (Homo sapiens)

- Synthesis of DNA (Homo sapiens)
  - DNA strand elongation (Homo sapiens)
    - Lagging Strand Synthesis (Homo sapiens)
      - Processive synthesis on the lagging strand (Homo sapiens)
        
        Removal of the Flap Intermediate (Homo sapiens)
        
        Removal of remaining Flap (Homo sapiens)
        
        FEN1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P39748 FEN1

Gene Names

FEN1, RAD2

Chain

chain:1-380

Reference Genes

BioGPS Gene:2237 FEN1

COSMIC (genes):FEN1 FEN1

CTD Gene:2237 FEN1

dbSNP Gene:2237 FEN1

ENSEMBL:ENSG00000168496 FEN1

HGNC:3650 FEN1

KEGG:hsa:2237 FEN1

Monarch:2237 FEN1

NCBI Gene:2237 FEN1

OMIM:600393 FEN1

UCSC:P39748 FEN1

Reference Transcript

RefSeq:NM_004111.5 FEN1

Other Identifiers

11751388_a_at

11751389_s_at

11758164_s_at

1515_at

1516_g_at

16725735

204767_PM_s_at

204767_s_at

204768_PM_s_at

204768_s_at

2237

2346374

2346375

2346376

2346381

2346382

2346384

2346388

3333228

3333229

3333231

3333232

3333233

3333234

3333235

3333236

3333237

3333238

41583_at

7940561

A_24_P73158

GE62924

GO:0000287

GO:0000724

GO:0000781

GO:0003677

GO:0003684

GO:0003690

GO:0003824

GO:0004518

GO:0004519

GO:0004523

GO:0004527

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005739

GO:0006260

GO:0006281

GO:0006284

GO:0006287

GO:0006302

GO:0006310

GO:0007613

GO:0008309

GO:0008409

GO:0009650

GO:0016020

GO:0016787

GO:0016788

GO:0017108

GO:0030145

GO:0032200

GO:0032201

GO:0032991

GO:0043137

GO:0043226

GO:0045876

GO:0046872

GO:0048256

GO:0050877

GO:0090304

GO:0140097

GO:0140098

HMNXSV003028411

ILMN_1755834

ILMN_2160929

PH_hs_0024778

TC11000541.hg

g12653112_3p_a_at

g6325465_3p_a_at

Participates

as an output of

as an input of

as a component of

This entity regulates

Positively

Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA (Homo sapiens)

Inferred To

fen1 [nucleoplasm] (Xenopus tropicalis)

FEN1 [nucleoplasm] (Bos taurus)

FEN1 [nucleoplasm] (Caenorhabditis elegans)

FEN1 [nucleoplasm] (Canis familiaris)

FEN1 [nucleoplasm] (Danio rerio)

FEN1 [nucleoplasm] (Dictyostelium discoideum)

FEN1 [nucleoplasm] (Drosophila melanogaster)

FEN1 [nucleoplasm] (Gallus gallus)

FEN1 [nucleoplasm] (Mus musculus)

FEN1 [nucleoplasm] (Plasmodium falciparum)

FEN1 [nucleoplasm] (Rattus norvegicus)

FEN1 [nucleoplasm] (Saccharomyces cerevisiae)

FEN1 [nucleoplasm] (Schizosaccharomyces pombe)

FEN1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_004102.1

OpenTargets

ENSG00000168496

ENSEMBL

ENSP00000305480, ENSG00000168496, ENST00000305885

HPA

ENSG00000168496-FEN1

GeneCards

FEN1

ZINC - Substances

FEN1_HUMAN

ZINC target

P39748

PRO

P39748

Pharos - Targets

P39748

GlyGen

P39748

ZINC - Predictions - Purchasable

FEN1_HUMAN

PDB

5E0V, 7QO1, 6TNZ, 3UVU, 3Q8K, 1UL1, 5KSE, 5ZOF, 5ZOG, 1U7B, 5K97, 5ZOE, 5ZOD, 3Q8M, 5FV7, 3Q8L, 5UM9

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P12004 PCNA	5	PCNA [nucleoplasm] (R-HSA-68439) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861)	0.964	22
UniProt:Q14191 WRN	2	WRN [nucleoplasm] (R-HSA-67387) monoSUMO1-K356,K496,K898-WRN [nucleoplasm] (R-HSA-4568904)	0.822	9
UniProt:P57081 WDR4	1	WDR4 [nucleoplasm] (R-HSA-6782341)	0.659	8
UniProt:P54132 BLM	2	BLM [nucleoplasm] (R-HSA-174881) 4SUMO2,3-BLM [nucleoplasm] (R-HSA-4568883)	0.611	4
UniProt:Q96NY9 MUS81	1	MUS81 [nucleoplasm] (R-HSA-5686443)	0.599	5
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	2
UniProt:P29084 GTF2E2	1	GTF2E2 [nucleoplasm] (R-HSA-65563)	0.527	2
UniProt:O96019 ACTL6A	1	ACTL6A [nucleoplasm] (R-HSA-2980912)	0.527	2
UniProt:Q8WTR2 DUS19			0.527	2
UniProt:Q96K76 USP47	1	USP47 [nucleoplasm] (R-HSA-5696961)	0.527	2
UniProt:P02675 FGB	5	FGB [extracellular region] (R-HSA-140584) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [plasma membrane] (R-HSA-140917) FGB(31-491) [extracellular region] (R-HSA-140846) FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	3

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