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HSPA9 [cytosol]
Stable Identifier
R-HSA-5251993
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
HSPA9 (mtHsp70), Stress-70 protein, mitochondrial, GRP75_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
HSP110s exchange ATP for ADP on HSP70s:ADP (Homo sapiens)
HSP70s:ADP [cytosol] (Homo sapiens)
HSPA9:ADP [cytosol] (Homo sapiens)
HSPA9 [cytosol] (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA9:ATP [cytosol] (Homo sapiens)
HSPA9 [cytosol] (Homo sapiens)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Homo sapiens)
HSP70s:ADP [cytosol] (Homo sapiens)
HSPA9:ADP [cytosol] (Homo sapiens)
HSPA9 [cytosol] (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA9:ATP [cytosol] (Homo sapiens)
HSPA9 [cytosol] (Homo sapiens)
Hikeshi binds HSP70s:ATP (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA9:ATP [cytosol] (Homo sapiens)
HSPA9 [cytosol] (Homo sapiens)
Hikeshi:HSP70s:ATP [cytosol] (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA9:ATP [cytosol] (Homo sapiens)
HSPA9 [cytosol] (Homo sapiens)
NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Homo sapiens)
Hikeshi:HSP70s:ATP [cytosol] (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA9:ATP [cytosol] (Homo sapiens)
HSPA9 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P38646 HSPA9
Gene Names
HSPA9, Stress-70 protein, mitochondrial, GRP75, HSPA9B, mt-HSP70
Chain
transit peptide:1-46, chain:47-679
Reference Genes
BioGPS Gene:3313 HSPA9
COSMIC (genes):HSPA9 HSPA9
CTD Gene:3313 HSPA9
dbSNP Gene:3313 HSPA9
ENSEMBL:ENSG00000113013 HSPA9
ENSEMBL_homo_sapiens_GENE:ENSG00000113013.16 HSPA9
HGNC:5244 HSPA9
KEGG Gene (Homo sapiens):3313 HSPA9
Monarch:3313 HSPA9
NCBI Gene:3313 HSPA9
OMIM:600548 HSPA9
UCSC:P38646 HSPA9
Reference Transcript
RefSeq:NM_004134.6 HSPA9
Other Identifiers
11742920_a_at
11742921_s_at
11750745_a_at
11752595_a_at
11759417_s_at
17000485
200690_PM_at
200690_at
200691_PM_s_at
200691_s_at
200692_PM_s_at
200692_s_at
241840_PM_at
241840_at
2529286
2529292
2529293
2877509
2877510
2877511
2877512
2877513
2877514
2877515
2877516
2877518
2877519
2877521
2877524
2877531
2877533
2877535
2877537
2877538
2877541
2877543
2877546
2877547
2877550
2877551
3313
41509_at
41510_s_at
75250_s_at
8114455
86392_at
A_24_P77676
A_24_P934295
GO:0000166
GO:0001401
GO:0002376
GO:0003723
GO:0003824
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005730
GO:0005737
GO:0005739
GO:0005743
GO:0005744
GO:0005759
GO:0005925
GO:0006457
GO:0006611
GO:0006790
GO:0006886
GO:0006913
GO:0007005
GO:0007007
GO:0012501
GO:0016226
GO:0016787
GO:0016887
GO:0019899
GO:0030154
GO:0030218
GO:0031072
GO:0031625
GO:0042026
GO:0042645
GO:0043066
GO:0043226
GO:0044183
GO:0045646
GO:0045647
GO:0048856
GO:0051082
GO:0051085
GO:0061024
GO:0070062
GO:0140275
GO:0140657
GO:0140662
GO:1902037
GO:1903707
HMNXSV003015869
Hs.184233.0.A1_3p_at
ILMN_1679209
L11066_at
L15189_s_at
PH_hs_0029370
TC05001832.hg
g12653414_3p_a_at
g4758569_3p_a_at
Participates
as a component of
HSPA9:ADP [cytosol] (Homo sapiens)
HSPA9:ATP [cytosol] (Homo sapiens)
Other forms of this molecule
HSPA9 [mitochondrial matrix]
HSPA9 [mitochondrial inner membrane]
HSPA9(1-679) [cytosol]
HSPA9(1-679) [mitochondrial intermembrane space]
HSPA9 [nucleoplasm]
Inferred To
mhsp70 [cytosol]
(Dictyostelium discoideum)
SSC1 [cytosol]
(Saccharomyces cerevisiae)
Hspa9 [cytosol]
(Mus musculus)
Hspa9 [cytosol]
(Rattus norvegicus)
HSPA9 [cytosol]
(Bos taurus)
HSPA9 [cytosol]
(Canis familiaris)
HSPA9 [cytosol]
(Plasmodium falciparum)
HSPA9 [cytosol]
(Sus scrofa)
ssc1 [cytosol]
(Schizosaccharomyces pombe)
hspa9 [cytosol]
(Danio rerio)
hspa9 [cytosol]
(Xenopus tropicalis)
hsp-6 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_004125.3
OpenTargets
ENSG00000113013
GeneCards
P38646
HPA
ENSG00000113013-HSPA9
Ensembl
ENST00000297185
,
ENSG00000113013
,
ENSP00000297185
PRO
P38646
Pharos - Targets
P38646
Orphanet
23644
PDB
6PMT
,
6NHK
,
4KBO
,
3N8E
,
6P2U
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.811
6
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.745
5
UniProt:Q8IWL3 HSCB
5
HSCB [mitochondrial matrix]
(R-HSA-1299438)
HSCB(1-30) [mitochondrial matrix]
(R-HSA-8986120)
HSCB(1-235) [mitochondrial inner membrane]
(R-HSA-1299443)
HSCB [mitochondrial inner membrane]
(R-HSA-1299447)
HSCB(1-235) [mitochondrial intermembrane space]
(R-HSA-1299456)
0.742
14
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.706
23
UniProt:Q9HAV7 GRPEL1
1
GRPEL1 [mitochondrial inner membrane]
(R-HSA-1252062)
0.669
5
UniProt:P21912 SDHB
2
SDHB [mitochondrial matrix]
(R-HSA-9854983)
SDHB [mitochondrial inner membrane]
(R-HSA-70985)
0.662
10
UniProt:O15350 TP73
3
PolyUb-TP73 [cytosol]
(R-HSA-8957256)
TP73 [cytosol]
(R-HSA-8957239)
TP73 [nucleoplasm]
(R-HSA-6798094)
0.637
11
UniProt:Q9H6A0 DENND2D
1
DENND2D [cytosol]
(R-HSA-8876071)
0.623
3
UniProt:P13693 TCTP
0.567
4
UniProt:A4D2J0 A4D2J0
0.556
3
UniProt:P38340 NTM1
0.556
3
UniProt:P53051 MALX3
0.556
3
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.527
2
UniProt:P15056 BRAF
20
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
0.527
2
UniProt:Q99592 ZBT18
0.527
2
UniProt:Q5SXM8 DNLZ
0.527
2
UniProt:O75165 DNAJC13
3
DNAJC13 [secretory granule membrane]
(R-HSA-6800951)
DNAJC13 [plasma membrane]
(R-HSA-6806255)
DNAJC13 [azurophil granule membrane]
(R-HSA-6799140)
0.527
2
UniProt:Q96NG3 ODAD4
0.527
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
5
UniProt:Q8ND83 SLAI1
0.527
2
UniProt:Q92733 PRCC
1
PRCC [nucleoplasm]
(R-HSA-8867896)
0.527
2
UniProt:Q13620 CUL4B
2
CUL4B [nucleoplasm]
(R-HSA-975973)
G76-NEDD8-K859-CUL4B [nucleoplasm]
(R-HSA-8952522)
0.527
2
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.527
3
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.527
3
UniProt:Q8WX92 NELFB
3
NELFB [nucleoplasm]
(R-HSA-112427)
NELFB [cytosol]
(R-HSA-9603526)
NELFB [mitochondrial outer membrane]
(R-HSA-9603553)
0.524
2
UniProt:Q99650 OSMR
1
OSMR [plasma membrane]
(R-HSA-448654)
0.499
4
UniProt:Q9H1K1 ISCU
1
ISCU [cytosol]
(R-HSA-9771680)
0.499
3
UniProt:Q8TDU6 GPBAR1
1
GPBAR1 [plasma membrane]
(R-HSA-444640)
0.463
3
UniProt:Q8N0X7 SPART
0.462
2
UniProt:Q00005 2ABB
0.462
2
UniProt:Q5U5X0 LYRM7
1
LYRM7 [mitochondrial matrix]
(R-HSA-9866252)
0.462
2
UniProt:P47985 UQCRFS1
3
UQCRFS1(1-274) [mitochondrial inner membrane]
(R-HSA-9906005)
UQCRFS1(1-274) [mitochondrial matrix]
(R-HSA-9906006)
UQCRFS1(79-274) [mitochondrial inner membrane]
(R-HSA-164278)
0.462
4
UniProt:A6NFY7 SDHAF1
1
SDHAF1 [mitochondrial matrix]
(R-HSA-9854988)
0.462
2
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