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SLC25A6 [mitochondrial inner membrane]
Stable Identifier
R-HSA-49745
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
ADP/ATP translocase 3 monomer, ADP,ATP carrier protein, liver isoform T2, adenine nucleotide translocator 3, ADP/ATP translocase 3, Adenine nucleotide translocator 3, ANT 3
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
Interactions of Vpr with host cellular proteins (Homo sapiens)
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization (Homo sapiens)
Association of Vpr with ANT1 (Homo sapiens)
ADP/ATP translocase monomer (generic) [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 [mitochondrial inner membrane] (Homo sapiens)
ANT1:Vpr complex [mitochondrial inner membrane] (Homo sapiens)
ADP/ATP translocase monomer (generic) [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 [mitochondrial inner membrane] (Homo sapiens)
Influenza Infection (Homo sapiens)
Influenza Virus Induced Apoptosis (Homo sapiens)
PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis (Homo sapiens)
PB1-F2: ANT 3 Complex [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 [mitochondrial inner membrane] (Homo sapiens)
Protein localization (Homo sapiens)
Mitochondrial protein import (Homo sapiens)
TIMM9:TIMM10 binds hydrophobic proteins (Homo sapiens)
TIMM9:TIMM10:Protein [mitochondrial inner membrane] (Homo sapiens)
Proteins Chaperoned by TIMM9:TIMM10 [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 [mitochondrial inner membrane] (Homo sapiens)
TIMM9:TIMM10 transfers proteins to TIMM22 (Homo sapiens)
TIMM9:TIMM10:Protein [mitochondrial inner membrane] (Homo sapiens)
Proteins Chaperoned by TIMM9:TIMM10 [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 [mitochondrial inner membrane] (Homo sapiens)
TIMM9:TIMM10:TIMM10B:TIM22:Protein [mitochondrial inner membrane] (Homo sapiens)
Proteins Chaperoned by TIMM9:TIMM10 [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 [mitochondrial inner membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of vitamins, nucleosides, and related molecules (Homo sapiens)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Homo sapiens)
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Homo sapiens)
SLC25A5,6 dimers [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 dimer [mitochondrial inner membrane] (Homo sapiens)
SLC25A6 [mitochondrial inner membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
12450408
The human mitochondrial ADP/ATP carriers: kinetic properties and biogenesis of wild-type and mutant proteins in the yeast S. cerevisiae.
De Marcos Lousa, C
,
Trézéguet, V
,
Dianoux, AC
,
Brandolin, G
,
Lauquin, GJ
Biochemistry
2002
External Reference Information
External Reference
UniProt:P12236 SLC25A6
Gene Names
SLC25A6, ANT3, CDABP0051
Chain
initiator methionine:1, chain:1-298, chain:2-298
Reference Genes
BioGPS Gene:293 SLC25A6
COSMIC (genes):SLC25A6 SLC25A6
CTD Gene:293 SLC25A6
dbSNP Gene:293 SLC25A6
ENSEMBL:ENSG00000169100 SLC25A6
HGNC:10992 SLC25A6
KEGG Gene (Homo sapiens):293 SLC25A6
Monarch:293 SLC25A6
NCBI Gene:293 SLC25A6
OMIM:300151 SLC25A6
OMIM:403000 SLC25A6
Reference Transcript
RefSeq:NM_001636.3 SLC25A6
Other Identifiers
0006420100
11729584_a_at
11729585_x_at
17116720
212085_at
212826_s_at
293
3997375
3997376
3997377
3997378
3997380
3997381
3997386
3997387
3997390
4033176
4033177
4033178
4033179
4033181
4033182
4033187
4033188
4033191
40435_at
40436_g_at
8171111
8177003
88085_at
A_23_P33752
A_33_P3411397
A_33_P3589217
GO:0003674
GO:0005347
GO:0005471
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005743
GO:0005744
GO:0006605
GO:0006626
GO:0006810
GO:0006915
GO:0007005
GO:0007267
GO:0008150
GO:0008219
GO:0015031
GO:0015866
GO:0015867
GO:0016020
GO:0016021
GO:0016032
GO:0022857
GO:0032991
GO:0043226
GO:0044403
GO:0050796
GO:0055085
Hs.164280.0.A1_3p_a_at
Hs.164280.1.A1_3p_at
ILMN_1671466
ILMN_3240838
J03592_at
PH_hs_0016939
TC0X000798.hg
TC0Y000115.hg
Participant Of
hasMember
ADP/ATP translocase monomer (generic) [mitochondrial inner membrane]
Proteins Chaperoned by TIMM9:TIMM10 [mitochondrial inner membrane]
hasComponent
PB1-F2: ANT 3 Complex [mitochondrial inner membrane]
SLC25A6 dimer [mitochondrial inner membrane]
input
PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis
Other forms of this molecule
SLC25A6 [mitochondrial intermembrane space]
Inferred To
slc25a5 [mitochondrial inner membrane] (Danio rerio)
slc25a5 [mitochondrial inner membrane] (Xenopus tropicalis)
sesB [mitochondrial inner membrane] (Drosophila melanogaster)
ant-1.4 [mitochondrial inner membrane] (Caenorhabditis elegans)
ant-1.1 [mitochondrial inner membrane] (Caenorhabditis elegans)
Homologues of SLC25A5 [mitochondrial inner membrane] (Caenorhabditis elegans)
Homologues of SLC25A5 [mitochondrial inner membrane] (Drosophila melanogaster)
ant-1.3 [mitochondrial inner membrane] (Caenorhabditis elegans)
ant-1.2 [mitochondrial inner membrane] (Caenorhabditis elegans)
Ant2 [mitochondrial inner membrane] (Drosophila melanogaster)
SLC25A6 [mitochondrial inner membrane] (Bos taurus)
SLC25A6 [mitochondrial inner membrane] (Canis familiaris)
SLC25A6 [mitochondrial inner membrane] (Gallus gallus)
SLC25A5 [mitochondrial inner membrane] (Caenorhabditis elegans)
Cross References
RefSeq
NP_001627.2
Target Pathogen
5b354852be737e166372e7c4
,
5b354852be737e166372ea71
OpenTargets
ENSG00000169100
HPA
ENSG00000169100-SLC25A6
GeneCards
P12236
Ensembl
ENSG00000169100
,
ENSP00000370808
,
ENST00000381401
PRO
P12236
HMDB Protein
HMDBP03918
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63010 AP2B1
4
AP2B1 [plasma membrane]
(R-HSA-167690)
AP2B1 [endolysosome membrane]
(R-HSA-6784827)
AP2B1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130489)
AP2B1 [cytosol]
(R-HSA-182166)
0.666
4
UniProt:Q5JR59 MTUS2
0.666
4
UniProt:P0C0U1 PB1
2
PB1-F2 [cytosol]
(R-FLU-169216)
PB1-F2 [mitochondrial intermembrane space]
(R-FLU-5146789)
0.591
5
UniProt:P21796 VDAC1
4
PolyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-6783079)
VDAC1 [mitochondrial intermembrane space]
(R-HSA-1267960)
K48polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-5205624)
VDAC1 [mitochondrial outer membrane]
(R-HSA-1267988)
0.564
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.564
2
UniProt:Q8WW24 TEKT4
0.556
3
UniProt:Q7Z3S9 NT2NA
0.556
3
UniProt:P36406 TRI23
0.556
3
UniProt:Q9UJV3-2 MID2
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:Q15654 TRIP6
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:Q77M19 Q77M19
0.527
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
2
UniProt:Q9HCL2 GPAM
1
GPAM(1-828) [mitochondrial outer membrane]
(R-HSA-61855)
0.499
3
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