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About
What is Reactome ?
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Digital Preservation
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Go!
p-5Y-PTK2 [cytosol]
Stable Identifier
R-HSA-5218711
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-5Y-FAK1, p(Y397,576,577,861,925)-FAK 1
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Homo sapiens)
p-5Y-PTK2 [cytosol] (Homo sapiens)
HSP90AA1 binds p-6Y-VEGFR2 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Homo sapiens)
p-5Y-PTK2 [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Homo sapiens)
p-5Y-PTK2 [cytosol] (Homo sapiens)
RHOA:GTP:Mg2+ binds ROCK1,ROCK2 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Homo sapiens)
p-5Y-PTK2 [cytosol] (Homo sapiens)
SRC-1 phosphorylates p-Y397-PTK2 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Homo sapiens)
p-5Y-PTK2 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
12387730
Site-specific phosphorylation of platelet focal adhesion kinase by low-density lipoprotein
Akkerman, JW
,
Relou, IA
,
Bax, LA
,
van Rijn, HJ
Biochem J
2003
External Reference Information
External Reference
UniProt:Q05397 PTK2
Gene Names
PTK2, FAK, FAK1
Chain
initiator methionine:, chain:2-1052
Reference Genes
BioGPS Gene:5747 PTK2
COSMIC (genes):PTK2 PTK2
CTD Gene:5747 PTK2
dbSNP Gene:5747 PTK2
ENSEMBL:ENSG00000169398 PTK2
ENSEMBL_homo_sapiens_GENE:ENSG00000169398.20 PTK2
HGNC:9611 PTK2
KEGG Gene (Homo sapiens):5747 PTK2
Monarch:5747 PTK2
NCBI Gene:5747 PTK2
OMIM:600758 PTK2
UCSC:Q05397 PTK2
Reference Transcript
RefSeq:NM_001199649.1 PTK2
RefSeq:NM_153831.3 PTK2
RefSeq:XM_017013673.1 PTK2
Other Identifiers
11716373_a_at
11716374_s_at
11747793_a_at
207821_PM_s_at
207821_s_at
208820_PM_at
208820_at
312_s_at
3156306
3156308
3156309
3156310
3156313
3156315
3156322
3156324
3156328
3156338
3156339
3156342
3156345
3156357
3156358
3156360
3156362
3156366
3156373
3156375
3156377
3156387
3156388
3156392
3156393
3156396
3156397
3156400
3156402
3156404
3156410
3156420
3156425
3156435
3156457
3156464
3156465
36117_at
52392_s_at
5747
8153223
A_23_P22096
A_23_P324679
A_23_P72050
GE79453
GE85906
GO:0000166
GO:0001525
GO:0001725
GO:0001890
GO:0001932
GO:0001934
GO:0002376
GO:0003007
GO:0003779
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0004725
GO:0005178
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0005929
GO:0005938
GO:0006468
GO:0007010
GO:0007155
GO:0007163
GO:0007166
GO:0007172
GO:0007173
GO:0007179
GO:0007229
GO:0007411
GO:0008092
GO:0008284
GO:0008360
GO:0008432
GO:0010033
GO:0010594
GO:0010632
GO:0010634
GO:0010718
GO:0010759
GO:0010763
GO:0012501
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0016787
GO:0018108
GO:0019901
GO:0019903
GO:0022408
GO:0023052
GO:0030010
GO:0030054
GO:0030154
GO:0030155
GO:0030163
GO:0030335
GO:0033628
GO:0034330
GO:0035995
GO:0036064
GO:0036211
GO:0038007
GO:0038096
GO:0042060
GO:0042127
GO:0042169
GO:0042995
GO:0043066
GO:0043087
GO:0043197
GO:0043226
GO:0043231
GO:0045667
GO:0045860
GO:0046777
GO:0048010
GO:0048013
GO:0048471
GO:0048856
GO:0048870
GO:0051128
GO:0051239
GO:0051493
GO:0051893
GO:0051897
GO:0060396
GO:0065003
GO:0065008
GO:0070161
GO:0090303
GO:0098772
GO:0120041
GO:0140096
GO:0140677
GO:1900024
GO:1902531
GO:2000060
GO:2000811
HMNXSV003030583
Hs.740.1.S2_3p_at
Hs.740.1.S2_3p_x_at
ILMN_1676305
ILMN_1714364
PH_hs_0025321
g5032000_3p_a_at
Participates
as a component of
VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
pY-PTK2 [cytosol]
p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
p-Y194,Y397-PTK2 [cytosol]
p-5Y,S732-PTK2 [cytosol]
p-6Y,S732-PTK2 [cytosol]
PTK2(773-1052) [cytosol]
PTK2(1-772) [cytosol]
PTK2 [cytosol]
p-Y397-PTK2 [cytosol]
p-6Y-PTK2 [cytosol]
Inferred To
phospho-PTK2 [cytosol]
(Canis familiaris)
Ghost homologue of p-5Y-PTK2 [cytosol]
(Sus scrofa)
phospho-p-5Y-PTK2 [cytosol]
(Bos taurus)
phospho-p-5Y-PTK2 [cytosol]
(Gallus gallus)
phospho-p-5Y-PTK2 [cytosol]
(Mus musculus)
phospho-p-5Y-PTK2 [cytosol]
(Rattus norvegicus)
Modified Residues
Name
O4'-phospho-L-tyrosine at 397
Coordinate
397
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 576
Coordinate
576
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 577
Coordinate
577
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 861
Coordinate
861
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 925
Coordinate
925
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001186578.1
,
XP_016869162.1
,
NP_722560.1
ZINC - World Drugs
FAK1_HUMAN
Guide to Pharmacology - Targets
2180
OpenTargets
ENSG00000169398
ZINC - FDA approved
FAK1_HUMAN
ZINC - Substances
FAK1_HUMAN
ZINC - Biogenic
FAK1_HUMAN
ZINC target
Q05397
PRO
Q05397
PDB
1OW8
,
6YQ1
,
4NY0
,
3PXK
,
4EBV
,
1OW7
,
7PI4
,
1OW6
,
4GU6
,
6LES
,
3S9O
,
4Q9S
,
6YVS
,
7W7Z
,
6YOJ
,
7W8B
,
2IJM
,
4GU9
,
4EBW
,
1K05
,
7W9U
,
6YXV
,
4KAB
,
6YVY
,
3BZ3
,
7W8I
,
3B71
,
1K04
,
6PW8
,
4I4E
,
6YT6
,
2ETM
,
4KAO
,
1MP8
,
6YR9
,
4K8A
,
4K9Y
,
6I8Z
,
4I4F
ZINC - Investigational
FAK1_HUMAN
ZINC - Metabolites
FAK1_HUMAN
HPA
ENSG00000169398-PTK2
GeneCards
Q05397
Ensembl
ENST00000395218
,
ENST00000521059
,
ENSP00000429474
,
ENSP00000429911
,
ENSG00000169398
,
ENSP00000341189
,
ENST00000522684
,
ENSP00000378644
,
ENST00000340930
Pharos - Targets
Q05397
ZINC - Predictions - Purchasable
FAK1_HUMAN
HMDB Protein
HMDBP01281
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49023 PXN
4
p-Y-PXN [plasma membrane]
(R-HSA-9031680)
PXN [plasma membrane]
(R-HSA-180493)
PXN [cytosol]
(R-HSA-210014)
p-Y31,Y118-PXN [cytosol]
(R-HSA-5218693)
0.942
19
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.924
9
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.751
13
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.745
7
UniProt:P05480 Src
13
SRC-2 [cytosol]
(R-MMU-191648)
phospho-MyrG-p-Y419-SRC [plasma membrane]
(R-MMU-1810408)
SRC-1 [plasma membrane]
(R-MMU-65043)
phospho-MyrG,p-Y530-SRC [plasma membrane]
(R-MMU-377598)
phospho-p-Y419-SRC [cytosol]
(R-MMU-377592)
Src [cytosol]
(R-MMU-418782)
phospho-p-Y419-SRC-1 [plasma membrane]
(R-MMU-112331)
MyrG-SRC [plasma membrane]
(R-MMU-8876922)
phospho-p-Y419-SRC [cytosol]
(R-MMU-8964276)
SRC [cytosol]
(R-MMU-9628701)
MyrG-p-Y424-Src [plasma membrane]
(R-MMU-9011258)
Activated Src [nucleoplasm]
(R-MMU-8937700)
p-Y416-Src [cytosol]
(R-MMU-8964306)
0.683
5
UniProt:O43294 TGFI1
0.678
3
UniProt:O60711 LPXN
0.659
4
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.659
4
UniProt:Q9H3S7 PTPN23
1
PTPN23 [nucleoplasm]
(R-HSA-9008924)
0.639
4
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.635
3
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.632
3
UniProt:Q96SB4 SRPK1
2
SRPK1 [nucleoplasm]
(R-HSA-9821984)
SRPK1 [cytosol]
(R-HSA-9729349)
0.59
2
UniProt:P56945 BCAR1
4
p-Y-BCAR1 [cytosol]
(R-HSA-372645)
p-Y12-BCAR1 [cytosol]
(R-HSA-5218739)
p-Y165,Y664-BCAR1 [cytosol]
(R-HSA-8848723)
BCAR1 [cytosol]
(R-HSA-201625)
0.589
2
UniProt:P07948 LYN
7
MyrG2-PalmC3-LYN [lysosomal membrane]
(R-HSA-9707903)
MyrG2-PalmC3-LYN [endocytic vesicle membrane]
(R-HSA-9705728)
LYN [plasma membrane]
(R-HSA-197943)
p-Y397-LYN [cytosol]
(R-HSA-8942608)
p-Y397-LYN [plasma membrane]
(R-HSA-2454229)
MyrG2-PalmC3-LYN [plasma membrane]
(R-HSA-9606875)
LYN [cytosol]
(R-HSA-354251)
0.573
2
UniProt:Q14451 GRB7
1
GRB7 [cytosol]
(R-HSA-204819)
0.57
3
UniProt:P29350-3 PTPN6
0.57
3
UniProt:Q9NP31 SH2D2A
1
SH2D2A [cytosol]
(R-HSA-4420125)
0.57
3
UniProt:Q68CZ2 TNS3
1
TNS3 [cytosol]
(R-HSA-8875524)
0.556
3
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.547
3
UniProt:Q824H6 Q824H6
0.543
3
UniProt:P78396 CCNA1
3
PolyUb-CCNA1 [nucleoplasm]
(R-HSA-6783068)
CCNA1 [cytosol]
(R-HSA-157446)
CCNA1 [nucleoplasm]
(R-HSA-68891)
0.536
2
UniProt:P42224 STAT1
8
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-Y701,S727-STAT1 [cytosol]
(R-HSA-9850842)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
STAT1 [cytosol]
(R-HSA-629622)
0.536
3
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.536
2
UniProt:P05120 SERPINB2
2
SERPINB2 [plasma membrane]
(R-HSA-159004)
SERPINB2 [extracellular region]
(R-HSA-158997)
0.527
2
UniProt:Q62219 TGFI1
0.524
3
UniProt:P16144 ITGB4
1
ITGB4 [plasma membrane]
(R-HSA-215947)
0.524
7
UniProt:P08631-2 HCK
0.508
2
UniProt:P29317 EPHA2
2
EPHA2 [plasma membrane]
(R-HSA-211422)
p-Y588,Y594-EPHA2 [plasma membrane]
(R-HSA-3928380)
0.488
3
UniProt:Q8TEW6 DOK4
1
DOK4 [cytosol]
(R-HSA-8847701)
0.488
2
UniProt:O60880 SH2D1A
1
SH2D1A [cytosol]
(R-HSA-5685108)
0.488
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
10
UniProt:Q80ZW7 Q80ZW7
0.463
2
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