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SEC61A1 [phagocytic vesicle membrane]
Stable Identifier
R-HSA-1236813
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
phagocytic vesicle membrane
Synonyms
Protein transport protein Sec61 subunit alpha isoform 1, S61A1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
ER-Phagosome pathway (Homo sapiens)
Egress of internalized antigen to the cytosol via sec61 (Homo sapiens)
Translocon [phagocytic vesicle membrane] (Homo sapiens)
SEC61 alpha [phagocytic vesicle membrane] (Homo sapiens)
SEC61A1 [phagocytic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P61619 SEC61A1
Gene Names
SEC61A1, SEC61A
Chain
chain:1-476
Reference Genes
BioGPS Gene:29927 SEC61A1
COSMIC (genes):SEC61A1 SEC61A1
CTD Gene:29927 SEC61A1
dbSNP Gene:29927 SEC61A1
ENSEMBL:ENSG00000058262 SEC61A1
HGNC:18276 SEC61A1
KEGG Gene (Homo sapiens):29927 SEC61A1
Monarch:29927 SEC61A1
NCBI Gene:29927 SEC61A1
OMIM:609213 SEC61A1
UCSC:P61619 SEC61A1
Reference Transcript
RefSeq:NM_013336.3 SEC61A1
Other Identifiers
0000540497
11739107_a_at
11749955_a_at
11755426_x_at
16945189
217716_s_at
222385_x_at
2641041
2641042
2641043
2641044
2641045
2641046
2641047
2641048
2641049
2641050
2641052
2641053
2641057
2641058
2641061
2641063
2641064
2641065
2641066
2641067
2641068
2641069
2641070
2641071
2641072
29927
45766_at
8082408
A_14_P100422
A_23_P212458
GE81823
GO:0002376
GO:0003674
GO:0005048
GO:0005262
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005783
GO:0005784
GO:0005789
GO:0005791
GO:0006605
GO:0006613
GO:0006614
GO:0006616
GO:0006620
GO:0006810
GO:0006950
GO:0007029
GO:0008150
GO:0008320
GO:0015031
GO:0016020
GO:0016021
GO:0022857
GO:0030176
GO:0031204
GO:0032991
GO:0034341
GO:0039019
GO:0043022
GO:0043226
GO:0045047
GO:0048856
GO:0055085
GO:0070588
HMNXSV003028370
ILMN_1659564
ILMN_1696952
PH_hs_0015718
TC03000670.hg
g13517988_3p_s_at
g7019414_3p_s_at
Participates
as a member of
SEC61 alpha [phagocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
SEC61A1 [endoplasmic reticulum membrane]
Cross References
RefSeq
NP_037468.1
OpenTargets
ENSG00000058262
GeneCards
P61619
HPA
ENSG00000058262-SEC61A1
Ensembl
ENST00000424880
,
ENSP00000243253
,
ENSP00000411445
,
ENSG00000058262
,
ENST00000243253
PRO
P61619
Pharos - Targets
P61619
Orphanet
26176
GlyGen
P61619
PDB
6W6L
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27824 CANX
2
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
CANX [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
0.597
4
UniProt:P11021 HSPA5
6
HSPA5 [extracellular region]
(R-HSA-351322)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
0.558
3
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.527
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.527
5
UniProt:P04578 env
7
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
0.462
2
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