Reactome | SEC61A1 [phagocytic vesicle membrane]

SEC61A1 [phagocytic vesicle membrane]

Stable Identifier

R-HSA-1236813

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

phagocytic vesicle membrane

Synonyms

Protein transport protein Sec61 subunit alpha isoform 1, S61A1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P61619 SEC61A1

Gene Names

SEC61A1, SEC61A

Chain

chain:1-476

Reference Genes

BioGPS Gene:29927 SEC61A1

COSMIC (genes):SEC61A1 SEC61A1

CTD Gene:29927 SEC61A1

dbSNP Gene:29927 SEC61A1

ENSEMBL:ENSG00000058262 SEC61A1

HGNC:18276 SEC61A1

KEGG Gene (Homo sapiens):29927 SEC61A1

Monarch:29927 SEC61A1

NCBI Gene:29927 SEC61A1

OMIM:609213 SEC61A1

UCSC:P61619 SEC61A1

Reference Transcript

RefSeq:NM_013336.3 SEC61A1

Other Identifiers

0000540497

11739107_a_at

11749955_a_at

11755426_x_at

16945189

217716_s_at

222385_x_at

2641041

2641042

2641043

2641044

2641045

2641046

2641047

2641048

2641049

2641050

2641052

2641053

2641057

2641058

2641061

2641063

2641064

2641065

2641066

2641067

2641068

2641069

2641070

2641071

2641072

29927

45766_at

8082408

A_14_P100422

A_23_P212458

GE81823

GO:0003674

GO:0005048

GO:0005262

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005783

GO:0005784

GO:0005789

GO:0005829

GO:0006605

GO:0006613

GO:0006614

GO:0006616

GO:0006620

GO:0006810

GO:0007029

GO:0008150

GO:0008320

GO:0015031

GO:0016020

GO:0016021

GO:0022857

GO:0030176

GO:0031204

GO:0032991

GO:0039019

GO:0043022

GO:0043226

GO:0045047

GO:0048856

GO:0055085

GO:0070588

HMNXSV003028370

ILMN_1659564

ILMN_1696952

PH_hs_0015718

TC03000670.hg

g13517988_3p_s_at

g7019414_3p_s_at

Participates

as a member of

SEC61 alpha [phagocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

SEC61A1 [endoplasmic reticulum membrane]

Cross References

RefSeq

NP_037468.1

OpenTargets

ENSG00000058262

HPA

ENSG00000058262-SEC61A1

GeneCards

P61619

Ensembl

ENST00000424880, ENSP00000411445, ENSG00000058262, ENSP00000243253, ENST00000243253

PRO

P61619

Orphanet

26176

PDB

6W6L

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27824 CANX	2	CANX [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.597	4
UniProt:P11021 HSPA5	6	HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.558	3
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	5
UniProt:P04578 env	7	Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Surface protein gp120 [viral envelope] (R-HIV-171211) ENV [viral envelope] (R-HIV-173439)	0.462	2

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