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PSMC2 [nucleoplasm]
Stable Identifier
R-HSA-174332
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
26S protease regulatory subunit 7, MSS1 protein
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC2 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC2 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC2 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC2 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC2 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC2 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC2 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35998 PSMC2
Gene Names
PSMC2, MSS1
Chain
initiator methionine:1, chain:2-433
Reference Genes
BioGPS Gene:5701 PSMC2
COSMIC (genes):PSMC2 PSMC2
CTD Gene:5701 PSMC2
dbSNP Gene:5701 PSMC2
ENSEMBL:ENSG00000161057 PSMC2
HGNC:9548 PSMC2
KEGG Gene (Homo sapiens):5701 PSMC2
Monarch:5701 PSMC2
NCBI Gene:5701 PSMC2
OMIM:154365 PSMC2
UCSC:P35998 PSMC2
Reference Transcript
RefSeq:NM_001204453.1 PSMC2
RefSeq:NM_002803.3 PSMC2
Other Identifiers
0005550364
11715901_a_at
11758736_at
17049965
201067_at
201068_s_at
238020_at
2642700
2642708
2642709
3017208
3017209
3017214
3017216
3017217
3017224
3017226
3017228
3017230
3017231
3017233
3017234
3017235
3017236
3017237
3017238
3017239
35353_at
47823_r_at
51032_at
5701
8135250
A_23_P304287
D11094_at
GE550496
GE61412
GO:0000165
GO:0000166
GO:0000209
GO:0000278
GO:0000502
GO:0000932
GO:0001649
GO:0002223
GO:0002376
GO:0002479
GO:0003674
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006511
GO:0006520
GO:0006521
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008134
GO:0008150
GO:0008540
GO:0009056
GO:0009058
GO:0010972
GO:0016020
GO:0016192
GO:0016579
GO:0016787
GO:0016887
GO:0017025
GO:0022607
GO:0022624
GO:0030154
GO:0030163
GO:0031145
GO:0031146
GO:0031410
GO:0032991
GO:0033209
GO:0034641
GO:0034655
GO:0034774
GO:0036402
GO:0036464
GO:0038061
GO:0038095
GO:0043161
GO:0043167
GO:0043197
GO:0043226
GO:0043312
GO:0043488
GO:0043687
GO:0044281
GO:0045899
GO:0048856
GO:0050852
GO:0055085
GO:0060071
GO:0061418
GO:0065003
GO:0070498
GO:0090090
GO:0090263
GO:1901800
GO:1901990
GO:1902036
GO:1904813
Hs.68467.0.S1_3p_at
ILMN_1768784
PH_hs_0003882
PH_hs_0040205
TC07000673.hg
g4506208_3p_a_at
Participant Of
hasComponent
26S proteasome [nucleoplasm]
Other forms of this molecule
PSMC2 [ficolin-1-rich granule lumen]
PSMC2 [extracellular region]
PSMC2 [secretory granule lumen]
PSMC2 [cytosol]
Inferred To
Rpt1 [nucleoplasm] (Drosophila melanogaster)
psmC2 [nucleoplasm] (Dictyostelium discoideum)
rpt-1 [nucleoplasm] (Caenorhabditis elegans)
PSMC2 [nucleoplasm] (Canis familiaris)
PSMC2 [nucleoplasm] (Sus scrofa)
psmc2 [nucleoplasm] (Danio rerio)
psmc2 [nucleoplasm] (Xenopus tropicalis)
Psmc2 [nucleoplasm] (Mus musculus)
Psmc2 [nucleoplasm] (Rattus norvegicus)
Cross References
RefSeq
NP_002794.1
,
NP_001191382.1
Target Pathogen
5b354852be737e166372ed6a
OpenTargets
ENSG00000161057
GeneCards
P35998
HPA
ENSG00000161057-PSMC2
Ensembl
ENSP00000292644
,
ENST00000292644
,
ENST00000435765
,
ENSP00000391211
,
ENSG00000161057
PRO
P35998
PDB
5VFS
,
5VGZ
,
6MSD
,
6MSE
,
5VHN
,
5VFT
,
5VHF
,
5VHO
,
5T0C
,
5LN3
,
5L4G
,
5VHM
,
6MSB
,
5T0J
,
5VFQ
,
5VFR
,
6MSK
,
5T0H
,
6MSJ
,
5VHI
,
5VHR
,
5VFP
,
6MSH
,
5VHJ
,
5T0I
,
5VHS
,
5GJQ
,
6MSG
,
5VFU
,
5M32
,
5VHP
,
5VHH
,
5VHQ
,
5T0G
,
5GJR
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [nucleoplasm]
(R-HSA-5689584)
UCHL5 [cytosol]
(R-HSA-1629778)
0.669
4
UniProt:O00487 PSMD14
5
PSMD14 [extracellular region]
(R-HSA-6806511)
PSMD14 [ficolin-1-rich granule lumen]
(R-HSA-6800419)
PSMD14 [secretory granule lumen]
(R-HSA-6800926)
PSMD14 [nucleoplasm]
(R-HSA-174329)
PSMD14 [cytosol]
(R-HSA-68722)
0.564
2
UniProt:Q96CV9 OPTN
4
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
0.556
3
UniProt:Q16186 ADRM1
1
ADRM1 [cytosol]
(R-HSA-5665939)
0.527
3
UniProt:P38936 CDKN1A
5
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
CDKN1A [cytosol]
(R-HSA-182512)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
CDKN1A [nucleoplasm]
(R-HSA-182585)
0.488
2
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