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ANXA2 [azurophil granule lumen]
Stable Identifier
R-HSA-6798766
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
azurophil granule lumen
Synonyms
Annexin A2, ANXA2_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)
ANXA2 [azurophil granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07355 ANXA2
Gene Names
ANXA2, ANX2, ANX2L4, CAL1H, LPC2D
Chain
initiator methionine:1, chain:2-339
Reference Genes
BioGPS Gene:302 ANXA2
COSMIC (genes):ANXA2 ANXA2
CTD Gene:302 ANXA2
dbSNP Gene:302 ANXA2
ENSEMBL:ENSG00000182718 ANXA2
HGNC:537 ANXA2
KEGG Gene (Homo sapiens):302 ANXA2
Monarch:302 ANXA2
NCBI Gene:302 ANXA2
OMIM:151740 ANXA2
UCSC:P07355 ANXA2
Reference Transcript
RefSeq:XM_017022091.1 ANXA2
RefSeq:NM_004039.2 ANXA2
RefSeq:NM_001002857.1 ANXA2
RefSeq:XM_017022090.1 ANXA2
RefSeq:NM_001136015.2 ANXA2
RefSeq:NM_001002858.2 ANXA2
Other Identifiers
0002480215
11738551_a_at
11738552_x_at
11740879_s_at
11740880_x_at
11747282_x_at
11753399_x_at
11754064_x_at
201590_PM_x_at
201590_x_at
210427_PM_x_at
210427_x_at
213503_PM_x_at
213503_x_at
302
31444_s_at
3167111
3627283
3627284
3627285
3627286
3627287
3627288
3627289
3627291
3627292
3627294
3627295
3627298
3627301
3627307
3627308
3627311
3627316
3627328
3627333
3627337
3627341
3627347
3627348
3627349
3627352
3627353
3627354
3627355
3627356
58798_at
757_at
76043_at
769_s_at
7989335
A_23_P146644
A_32_P94798
D00017_at
D28364_at
GE61578
GE79122
GO:0001525
GO:0001765
GO:0001786
GO:0001921
GO:0002020
GO:0002091
GO:0002376
GO:0003674
GO:0003723
GO:0004859
GO:0004867
GO:0005262
GO:0005509
GO:0005515
GO:0005544
GO:0005546
GO:0005575
GO:0005576
GO:0005604
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005811
GO:0005886
GO:0005912
GO:0006810
GO:0006900
GO:0006950
GO:0007009
GO:0007155
GO:0008092
GO:0008150
GO:0008289
GO:0009056
GO:0009058
GO:0009986
GO:0010756
GO:0010951
GO:0016020
GO:0016192
GO:0016323
GO:0016363
GO:0019834
GO:0019899
GO:0022607
GO:0022857
GO:0030154
GO:0030234
GO:0030312
GO:0030496
GO:0031012
GO:0031340
GO:0031410
GO:0031902
GO:0031982
GO:0032804
GO:0032991
GO:0034641
GO:0035578
GO:0036035
GO:0042470
GO:0042789
GO:0042802
GO:0043086
GO:0043167
GO:0043226
GO:0044090
GO:0044548
GO:0045121
GO:0045921
GO:0045944
GO:0046790
GO:0048306
GO:0048646
GO:0048856
GO:0050767
GO:0051604
GO:0055085
GO:0061024
GO:0062023
GO:0070062
GO:0070588
GO:0090575
GO:0098609
GO:0098641
GO:0098797
GO:1905581
GO:1905597
GO:1905599
GO:1905602
GO:1905686
GO:1990665
GO:1990667
HMNXSV003048221
ILMN_1711899
ILMN_1755937
ILMN_2409167
PH_hs_0030492
TC09000149.hg
TC09001875.hg
TC15001505.hg
g12655074_3p_a_at
g187147_3p_x_at
Participates
as a member of
Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)
Other forms of this molecule
ANXA2 [cytosol]
ANXA2 [external side of plasma membrane]
ANXA2 [extracellular region]
Inferred To
AnxB10 [azurophil granule lumen]
(Drosophila melanogaster)
nex-4 [azurophil granule lumen]
(Caenorhabditis elegans)
nxnA [azurophil granule lumen]
(Dictyostelium discoideum)
Anxa2 [azurophil granule lumen]
(Mus musculus)
Anxa2 [azurophil granule lumen]
(Rattus norvegicus)
ANXA2 [azurophil granule lumen]
(Bos taurus)
ANXA2 [azurophil granule lumen]
(Canis familiaris)
ANXA2 [azurophil granule lumen]
(Dictyostelium discoideum)
ANXA2 [azurophil granule lumen]
(Gallus gallus)
ANXA2 [azurophil granule lumen]
(Sus scrofa)
anxa2a [azurophil granule lumen]
(Danio rerio)
Homologues of ANXA2 [azurophil granule lumen]
(Canis familiaris)
Homologues of ANXA2 [azurophil granule lumen]
(Dictyostelium discoideum)
anxa2 [azurophil granule lumen]
(Xenopus tropicalis)
Cross References
RefSeq
XP_016877579.1
,
XP_016877580.1
,
NP_001002858.1
,
NP_001002857.1
,
NP_001129487.1
,
NP_004030.1
OpenTargets
ENSG00000182718
GeneCards
P07355
HPA
ENSG00000182718-ANXA2
Ensembl
ENSP00000503855
,
ENSP00000503757
,
ENST00000678061
,
ENSG00000182718
,
ENST00000421017
,
ENSP00000504164
,
ENST00000557906
,
ENSP00000387545
,
ENSP00000346032
,
ENST00000332680
,
ENST00000451270
,
ENST00000558558
,
ENST00000678870
,
ENSP00000504035
,
ENSP00000453859
,
ENSP00000452981
,
ENSP00000453694
,
ENSP00000411352
,
ENST00000679109
,
ENSP00000503447
,
ENST00000677968
,
ENST00000559956
,
ENSP00000452858
,
ENSP00000379342
,
ENST00000559818
,
ENST00000678450
,
ENSP00000452895
,
ENST00000560468
,
ENST00000396024
PRO
P07355
Pharos - Targets
P07355
HMDB Protein
HMDBP02277
PDB
5LQ2
,
5N7F
,
6TWQ
,
6TWU
,
5N7G
,
2HYU
,
2HYV
,
4FTG
,
2HYW
,
5LPU
,
5LQ0
,
5N7D
,
6TWY
,
5LPX
,
4DRW
,
4HRH
,
6TWX
,
1XJL
,
1W7B
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15363 P37
0.78
24
UniProt:Q14508 WFDC2
0.736
36
UniProt:Q15599 NHRF2
0.65
6
UniProt:P10636-8 MAPT
2
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.641
7
UniProt:P07355 ANXA2
4
ANXA2 [cytosol]
(R-HSA-5263667)
ANXA2 [external side of plasma membrane]
(R-HSA-5336164)
ANXA2 [extracellular region]
(R-HSA-6806242)
ANXA2 [azurophil granule lumen]
(R-HSA-6798766)
0.622
5
UniProt:P75409 CARDS
0.619
6
UniProt:Q8NBP7 PCSK9
5
PCSK9 [endolysosome membrane]
(R-HSA-6784823)
PCSK9 [lysosomal membrane]
(R-HSA-8855128)
PCSK9 [extracellular region]
(R-HSA-6784727)
p-PCSK9 [endoplasmic reticulum lumen]
(R-HSA-8956943)
PCSK9 [endoplasmic reticulum lumen]
(R-HSA-8956745)
0.61
7
UniProt:P60903 S100A10
1
S100A10 [external side of plasma membrane]
(R-HSA-5336168)
0.602
4
UniProt:P40692 MLH1
3
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 [nucleoplasm]
(R-HSA-912495)
0.602
7
UniProt:P12004 PCNA
5
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
PCNA [nucleoplasm]
(R-HSA-68439)
0.573
2
UniProt:Q99IB8-PRO_0000045602
0.57
5
IntAct:EBI-6863782 NS3
0.564
2
UniProt:B7UM99 TIR
0.557
3
UniProt:Q7DB77 TIR
0.527
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
2
UniProt:Q15811-1 ITSN1
0.524
2
UniProt:Q9NUX5 POT1
1
POT1 [nucleoplasm]
(R-HSA-174890)
0.508
2
UniProt:P03950 ANG
2
ANG [cytosol]
(R-HSA-9708345)
ANG [extracellular region]
(R-HSA-5692435)
0.484
6
UniProt:P27958-PRO_0000037575
0.463
2
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.463
3
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