Reactome | ANXA2 [azurophil granule lumen]

ANXA2 [azurophil granule lumen]

Stable Identifier

R-HSA-6798766

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

azurophil granule lumen

Synonyms

Annexin A2, ANXA2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P07355 ANXA2

Gene Names

ANXA2, ANX2, ANX2L4, CAL1H, LPC2D

Chain

initiator methionine:1, chain:2-339

Reference Genes

BioGPS Gene:302 ANXA2

COSMIC (genes):ANXA2 ANXA2

CTD Gene:302 ANXA2

dbSNP Gene:302 ANXA2

ENSEMBL:ENSG00000182718 ANXA2

HGNC:537 ANXA2

KEGG Gene (Homo sapiens):302 ANXA2

Monarch:302 ANXA2

NCBI Gene:302 ANXA2

OMIM:151740 ANXA2

UCSC:P07355 ANXA2

Reference Transcript

Other Identifiers

0002480215

11738551_a_at

11738552_x_at

11740879_s_at

11740880_x_at

11747282_x_at

11753399_x_at

11754064_x_at

201590_x_at

210427_x_at

213503_x_at

302

31444_s_at

3167111

3627283

3627284

3627285

3627286

3627287

3627288

3627289

3627291

3627292

3627294

3627295

3627298

3627301

3627307

3627308

3627311

3627316

3627328

3627333

3627337

3627352

3627353

3627354

3627355

58798_at

757_at

76043_at

769_s_at

7989335

A_23_P146644

A_32_P94798

D00017_at

D28364_at

GE61578

GE79122

GO:0001525

GO:0001765

GO:0001786

GO:0001921

GO:0002020

GO:0002376

GO:0003674

GO:0003723

GO:0004859

GO:0004867

GO:0005262

GO:0005509

GO:0005515

GO:0005544

GO:0005546

GO:0005575

GO:0005576

GO:0005604

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005811

GO:0005886

GO:0005912

GO:0006810

GO:0006900

GO:0007155

GO:0007165

GO:0008092

GO:0008150

GO:0008289

GO:0009056

GO:0009986

GO:0010951

GO:0016020

GO:0016032

GO:0016192

GO:0016323

GO:0019834

GO:0019899

GO:0022607

GO:0022857

GO:0030154

GO:0030234

GO:0030496

GO:0031012

GO:0031267

GO:0031340

GO:0031410

GO:0031902

GO:0031982

GO:0032804

GO:0032991

GO:0035578

GO:0035722

GO:0036035

GO:0042470

GO:0042802

GO:0043086

GO:0043167

GO:0043226

GO:0043312

GO:0044090

GO:0044147

GO:0044403

GO:0044548

GO:0045121

GO:0046790

GO:0048306

GO:0048646

GO:0048856

GO:0052362

GO:0052405

GO:0055085

GO:0061024

GO:0062023

GO:0070062

GO:0070588

GO:0098609

GO:0098641

GO:1905581

GO:1905597

GO:1905599

GO:1905602

GO:1990665

GO:1990667

HMNXSV003048221

ILMN_1711899

ILMN_1755937

ILMN_2409167

PH_hs_0030492

TC09000149.hg

TC09001875.hg

TC15001505.hg

g12655074_3p_a_at

g187147_3p_x_at

Participates

as a member of

Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)

Other forms of this molecule

ANXA2 [cytosol]

ANXA2 [external side of plasma membrane]

ANXA2 [extracellular region]

Inferred To

nxnA [azurophil granule lumen] (Dictyostelium discoideum)

Anxa2 [azurophil granule lumen] (Mus musculus)

Anxa2 [azurophil granule lumen] (Rattus norvegicus)

ANXA2 [azurophil granule lumen] (Bos taurus)

ANXA2 [azurophil granule lumen] (Canis familiaris)

ANXA2 [azurophil granule lumen] (Dictyostelium discoideum)

ANXA2 [azurophil granule lumen] (Gallus gallus)

anxa2a [azurophil granule lumen] (Danio rerio)

Homologues of ANXA2 [azurophil granule lumen] (Canis familiaris)

Homologues of ANXA2 [azurophil granule lumen] (Dictyostelium discoideum)

Cross References

RefSeq

XP_016877579.1, NP_004030.1, NP_001002857.1, NP_001129487.1, NP_001002858.1, XP_016877580.1

Target Pathogen

5b354852be737e166372e7c6

OpenTargets

ENSG00000182718

GeneCards

P07355

HPA

ENSG00000182718-ANXA2

Ensembl

ENST00000396024, ENST00000451270, ENST00000421017, ENST00000332680, ENSP00000379342, ENSP00000346032, ENSP00000387545, ENSP00000411352, ENSG00000182718

PRO

P07355

HMDB Protein

HMDBP02277

PDB

4HRH, 2HYU, 5LQ0, 4DRW, 6TWQ, 5N7D, 5N7F, 6TWX, 5LPX, 6TWY, 2HYW, 4FTG, 1W7B, 5N7G, 2HYV, 5LQ2, 6TWU, 5LPU, 1XJL

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15363 P37			0.78	24
UniProt:Q14508 WFDC2			0.736	36
UniProt:Q15599 NHRF2			0.65	6
UniProt:P10636-8 MAPT	2	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.641	7
UniProt:P07355 ANXA2	4	ANXA2 [external side of plasma membrane] (R-HSA-5336164) ANXA2 [cytosol] (R-HSA-5263667) ANXA2 [extracellular region] (R-HSA-6806242) ANXA2 [azurophil granule lumen] (R-HSA-6798766)	0.622	5
UniProt:P75409 CARDS			0.619	6
UniProt:Q8NBP7 PCSK9	5	PCSK9 [lysosomal membrane] (R-HSA-8855128) PCSK9 [endolysosome membrane] (R-HSA-6784823) PCSK9 [extracellular region] (R-HSA-6784727) p-PCSK9 [endoplasmic reticulum lumen] (R-HSA-8956943) PCSK9 [endoplasmic reticulum lumen] (R-HSA-8956745)	0.61	7
UniProt:P40692 MLH1	3	MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 [nucleoplasm] (R-HSA-912495)	0.602	7
UniProt:P60903 S100A10	1	S100A10 [external side of plasma membrane] (R-HSA-5336168)	0.602	4
UniProt:P12004 PCNA	5	K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) SUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.573	2
UniProt:Q99IB8-PRO_0000045602			0.57	5
IntAct:EBI-6863782 NS3			0.564	2
UniProt:B7UM99 TIR			0.557	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:Q7DB77 TIR			0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q9NUX5 POT1	1	POT1 [nucleoplasm] (R-HSA-174890)	0.508	2
UniProt:P03950 ANG	2	ANG [extracellular region] (R-HSA-5692435) ANG [cytosol] (R-HSA-9708345)	0.484	6
UniProt:P27958-PRO_0000037575			0.463	2
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.463	3

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