Reactome | ANXA2 [azurophil granule lumen]

ANXA2 [azurophil granule lumen]

Stable Identifier

R-HSA-6798766

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

azurophil granule lumen

Synonyms

Annexin A2, ANXA2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P07355 ANXA2

Gene Names

ANXA2, ANX2, ANX2L4, CAL1H, LPC2D

Chain

initiator methionine:1, chain:2-339

Reference Genes

BioGPS Gene:302 ANXA2

COSMIC (genes):ANXA2 ANXA2

CTD Gene:302 ANXA2

dbSNP Gene:302 ANXA2

ENSEMBL:ENSG00000182718 ANXA2

HGNC:537 ANXA2

KEGG Gene (Homo sapiens):302 ANXA2

Monarch:302 ANXA2

NCBI Gene:302 ANXA2

OMIM:151740 ANXA2

UCSC:P07355 ANXA2

Reference Transcript

Other Identifiers

0002480215

11738551_a_at

11738552_x_at

11740879_s_at

11740880_x_at

11747282_x_at

11753399_x_at

11754064_x_at

1W7B

1XJL

201590_x_at

210427_x_at

213503_x_at

2HYU

2HYV

2HYW

302

31444_s_at

3167111

3627283

3627284

3627285

3627286

3627287

3627288

3627289

3627291

3627292

3627294

3627295

3627298

3627301

3627307

3627308

3627311

3627316

3627328

3627333

3627337

3627352

3627353

3627354

3627355

4311

46964

4DRW

4FTG

4HRH

58798_at

5LPU

5LPX

5LQ0

5LQ2

5N7D

5N7F

5N7G

61798

757_at

76043_at

769_s_at

7989335

A0A024R5Z7

A_23_P146644

A_32_P94798

AAH01388

AAH09564

AAH15834

AAH16774

AAH21114

AAH23990

AAH52558

AAH52567

AAH66955

AAH68065

AAH93056

AAP36100

AC087385

ADO22157

ANXA2

ANXA2-201

ANXA2-202

ANXA2-203

ANXA2-204

BAA00013

BC001388

BC009564

BC015834

BC016774

BC021114

BC023990

BC052558

BC052567

BC066955

BC068065

BC093056

BT007432

BX640598

CAB004311

CAE45704

CCDS10175

CCDS32256

CH471082

D00017

D00017_at

D28364_at

EAW77583

EAW77584

EAW77585

EAW77586

ENSG00000182718

ENSP00000346032

ENSP00000379342

ENSP00000387545

ENSP00000411352

ENST00000332680

ENST00000332680.8

ENST00000396024

ENST00000396024.7

ENST00000421017

ENST00000421017.6

ENST00000451270

ENST00000451270.6

EntrezGene:302

EntrezGene:ANXA2

g12655074_3p_a_at

g187147_3p_x_at

GE61578

GE79122

GO:0001525

GO:0001726

GO:0001765

GO:0001786

GO:0001921

GO:0001934

GO:0002020

GO:0002376

GO:0003417

GO:0003674

GO:0003723

GO:0004859

GO:0005262

GO:0005509

GO:0005515

GO:0005544

GO:0005546

GO:0005575

GO:0005576

GO:0005604

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005769

GO:0005773

GO:0005811

GO:0005829

GO:0005886

GO:0005913

GO:0005938

GO:0006464

GO:0006810

GO:0006900

GO:0006950

GO:0007155

GO:0007165

GO:0007589

GO:0008092

GO:0008150

GO:0008283

GO:0008289

GO:0009056

GO:0009986

GO:0010755

GO:0016020

GO:0016192

GO:0016323

GO:0017137

GO:0019834

GO:0019897

GO:0019899

GO:0022607

GO:0022857

GO:0030154

GO:0030198

GO:0030199

GO:0030234

GO:0030496

GO:0031012

GO:0031214

GO:0031340

GO:0031410

GO:0031902

GO:0031982

GO:0032332

GO:0032804

GO:0032991

GO:0035578

GO:0035722

GO:0035749

GO:0036035

GO:0040007

GO:0042383

GO:0042470

GO:0042592

GO:0042730

GO:0042802

GO:0043086

GO:0043167

GO:0043220

GO:0043226

GO:0043312

GO:0044090

GO:0044147

GO:0044354

GO:0044403

GO:0044548

GO:0044730

GO:0044794

GO:0045121

GO:0046790

GO:0048146

GO:0048306

GO:0048471

GO:0048646

GO:0048856

GO:0051099

GO:0051290

GO:0051480

GO:0051604

GO:0051928

GO:0052362

GO:0052405

GO:0055085

GO:0060956

GO:0061024

GO:0062023

GO:0065003

GO:0070062

GO:0070588

GO:0072659

GO:0097066

GO:0098609

GO:0098641

GO:0098772

GO:0099511

GO:1903902

GO:1905581

GO:1905597

GO:1905599

GO:1905602

GO:1990667

GQ891295

H0YKL9

H0YKN4

H0YKS4

H0YKV8

H0YKX9

H0YKZ7

H0YL33

H0YLE2

H0YLV6

H0YMD0

H0YMD9

H0YMM1

H0YMT9

H0YMU9

H0YMW4

H0YN28

H0YN42

H0YN52

H0YNA0

H0YNB8

H0YNP5

HGNC:537

HPA046964

HPA061798

ILMN_1711899

ILMN_1755937

ILMN_2409167

IPR001464

IPR002389

IPR018252

IPR018502

IPR037104

MIM:151740

NM_001002857

NM_001002858

NM_001136015

NM_004039

NP_001002857

NP_001002858

NP_001129487

NP_004030

PF00191

PH_hs_0030492

PR00196

PR00198

SM00335

TC09000149.hg

TC09001875.hg

TC15001505.hg

UPI0000161B7A

UPI0000366A50

XM_017022090

XM_017022091

XM_017022092

XM_017022093

XM_024449908

XP_016877579

XP_016877580

XP_016877581

XP_016877582

XP_024305676

Participant Of

hasMember

Azurophil granule lumen proteins [azurophil granule lumen]

Other forms of this molecule

ANXA2 [cytosol]

ANXA2 [external side of plasma membrane]

ANXA2 [extracellular region]

Inferred To

AnxB10 [azurophil granule lumen] (Drosophila melanogaster)

nxnA [azurophil granule lumen] (Dictyostelium discoideum)

Anxa2 [azurophil granule lumen] (Mus musculus)

Anxa2 [azurophil granule lumen] (Rattus norvegicus)

ANXA2 [azurophil granule lumen] (Bos taurus)

ANXA2 [azurophil granule lumen] (Canis familiaris)

ANXA2 [azurophil granule lumen] (Dictyostelium discoideum)

ANXA2 [azurophil granule lumen] (Gallus gallus)

ANXA2 [azurophil granule lumen] (Sus scrofa)

anxa2a [azurophil granule lumen] (Danio rerio)

Homologues of ANXA2 [azurophil granule lumen] (Dictyostelium discoideum)

anxa2 [azurophil granule lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_001002857.1, NP_001002858.1, XP_016877580.1, XP_016877579.1, NP_001129487.1, NP_004030.1

Target Pathogen

5b354852be737e166372e7c6

OpenTargets

ENSG00000182718

GeneCards

P07355

HPA

ENSG00000182718-ANXA2

Ensembl

ENSP00000346032, ENST00000451270, ENST00000332680, ENSP00000379342, ENST00000396024, ENSP00000387545, ENST00000421017, ENSP00000411352, ENSG00000182718

PRO

P07355

HMDB Protein

HMDBP02277

PDB

5N7F, 5LQ2, 5N7G, 4FTG, 2HYV, 1W7B, 2HYW, 1XJL, 5N7D, 5LPU, 4DRW, 5LPX, 5LQ0, 2HYU, 4HRH

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15363 P37			0.78	24
UniProt:Q14508 WFDC2			0.736	37
UniProt:P10636-8 MAPT	2	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.641	7
UniProt:P07355 ANXA2	4	ANXA2 [external side of plasma membrane] (R-HSA-5336164) ANXA2 [cytosol] (R-HSA-5263667) ANXA2 [extracellular region] (R-HSA-6806242) ANXA2 [azurophil granule lumen] (R-HSA-6798766)	0.622	5
UniProt:P75409 CARDS			0.619	6
UniProt:Q8NBP7 PCSK9	5	PCSK9 [lysosomal membrane] (R-HSA-8855128) PCSK9 [endolysosome membrane] (R-HSA-6784823) PCSK9 [extracellular region] (R-HSA-6784727) p-PCSK9 [endoplasmic reticulum lumen] (R-HSA-8956943) PCSK9 [endoplasmic reticulum lumen] (R-HSA-8956745)	0.61	7
UniProt:P40692 MLH1	3	MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 [nucleoplasm] (R-HSA-912495)	0.602	7
UniProt:P60903 S100A10	1	S100A10 [external side of plasma membrane] (R-HSA-5336168)	0.602	4
UniProt:P12004 PCNA	5	K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) SUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.573	2
UniProt:Q99IB8-PRO_0000045602			0.57	5
IntAct:EBI-6863782 NS3			0.564	2
UniProt:P03950 ANG	1	ANG [extracellular region] (R-HSA-5692435)	0.537	6
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q9NUX5 POT1	1	POT1 [nucleoplasm] (R-HSA-174890)	0.508	2
UniProt:P46092 CCR10	1	CCR10 [plasma membrane] (R-HSA-373126)	0.499	2
UniProt:P27958-PRO_0000037575			0.463	2
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.463	3

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