Reactome | TBC1D15 [cytosol]

TBC1D15 [cytosol]

Stable Identifier

R-HSA-8854150

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TBC1 domain family member 15, TBC15_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8TC07 TBC1D15

Gene Names

TBC1D15

Chain

initiator methionine:1, chain:2-691

Reference Genes

BioGPS Gene:64786 TBC1D15

COSMIC (genes):TBC1D15 TBC1D15

CTD Gene:64786 TBC1D15

dbSNP Gene:64786 TBC1D15

ENSEMBL:ENSG00000121749 TBC1D15

ENSEMBL:ENSG00000121749.16 TBC1D15

HGNC:25694 TBC1D15

KEGG Gene (Homo sapiens):64786 TBC1D15

Monarch:64786 TBC1D15

NCBI Gene:64786 TBC1D15

OMIM:612662 TBC1D15

UCSC:Q8TC07 TBC1D15

Reference Transcript

Other Identifiers

11727377_a_at

11727378_at

11757471_s_at

16754208

218268_PM_at

218268_at

230072_PM_at

230072_at

3422327

3422328

3422333

3422334

3422336

3422338

3422339

3422341

3422344

3422345

3422346

3422348

3422350

3422355

3422359

3422364

3422367

3422368

3422370

3422371

3422373

3422374

3422375

3422383

3422384

3422385

46955_at

64420_at

64786

70482_at

76716_at

7957186

82931_at

A_23_P139558

GE56826

GO:0005096

GO:0005515

GO:0005576

GO:0005737

GO:0043087

GO:0090630

GO:0098772

HMNXSV003022168

Hs.146220.0.A1_3p_at

ILMN_1803941

PH_hs_0039971

TC12000628.hg

TC12002446.hg

g12232450_3p_at

This entity regulates

Positively

TBC1D15 accelerates GTP hydrolysis by RAB7 (Homo sapiens)

Inferred To

GYP7 [cytosol] (Saccharomyces cerevisiae)

Tbc1d15 [cytosol] (Mus musculus)

Tbc1d15 [cytosol] (Rattus norvegicus)

tbc-14 [cytosol] (Caenorhabditis elegans)

gyp7 [cytosol] (Schizosaccharomyces pombe)

tbc1d15 [cytosol] (Xenopus tropicalis)

TBC1D15 [cytosol] (Bos taurus)

TBC1D15 [cytosol] (Canis familiaris)

TBC1D15 [cytosol] (Danio rerio)

TBC1D15 [cytosol] (Dictyostelium discoideum)

TBC1D15 [cytosol] (Gallus gallus)

TBC1D15 [cytosol] (Plasmodium falciparum)

TBC1D15 [cytosol] (Sus scrofa)

Tbc1d15-17 [cytosol] (Drosophila melanogaster)

Homologues of TBC1D15 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_073608.4, NP_001139686.1, NP_001139685.2

OpenTargets

ENSG00000121749

GeneCards

Q8TC07

HPA

ENSG00000121749-TBC1D15

Ensembl

ENSP00000318262, ENST00000319106, ENSP00000448182, ENST00000485960, ENSP00000420678, ENSG00000121749, ENST00000550746

PRO

Q8TC07

Pharos - Targets

Q8TC07

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CV9 OPTN	5	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907)	0.805	9
UniProt:Q96MT8 CEP63	1	CEP63 [cytosol] (R-HSA-380267)	0.739	5
UniProt:O95166 GABARAP	3	GABARAP [autophagosome membrane] (R-HSA-5683634) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [cytosol] (R-HSA-975521)	0.591	5
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.556	3
UniProt:Q96MT8-3 CEP63			0.556	3
UniProt:Q9P1Z2 CACO1			0.556	3
UniProt:P60520 GABARAPL2	3	GABARAPL2 [autophagosome membrane] (R-HSA-5683633) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [cytosol] (R-HSA-5671758)	0.544	2
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [autophagosome membrane] (R-HSA-5683637) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [cytosol] (R-HSA-5671757)	0.544	2
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651)	0.544	2
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	2

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