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TBC1D15 [cytosol]
Stable Identifier
R-HSA-8854150
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
TBC1 domain family member 15, TBC15_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Rab regulation of trafficking (Homo sapiens)
TBC/RABGAPs (Homo sapiens)
TBC1D15 accelerates GTP hydrolysis by RAB7 (Homo sapiens)
TBC1D15 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TC07 TBC1D15
Gene Names
TBC1D15
Chain
initiator methionine:, chain:2-691
Reference Genes
BioGPS Gene:64786 TBC1D15
COSMIC (genes):TBC1D15 TBC1D15
CTD Gene:64786 TBC1D15
dbSNP Gene:64786 TBC1D15
ENSEMBL:ENSG00000121749 TBC1D15
ENSEMBL_homo_sapiens_GENE:ENSG00000121749.16 TBC1D15
HGNC:25694 TBC1D15
KEGG Gene (Homo sapiens):64786 TBC1D15
Monarch:64786 TBC1D15
NCBI Gene:64786 TBC1D15
OMIM:612662 TBC1D15
UCSC:Q8TC07 TBC1D15
Reference Transcript
RefSeq:NM_001146214.1 TBC1D15
RefSeq:NM_022771.4 TBC1D15
RefSeq:NM_001146213.1 TBC1D15
Other Identifiers
11727377_a_at
11727378_at
11757471_s_at
16754208
218268_PM_at
218268_at
230072_PM_at
230072_at
3422327
3422328
3422333
3422334
3422336
3422338
3422339
3422341
3422344
3422345
3422346
3422348
3422350
3422355
3422359
3422364
3422367
3422368
3422370
3422371
3422373
3422374
3422375
3422383
3422384
3422385
46955_at
64420_at
64786
70482_at
76716_at
7957186
82931_at
A_23_P139558
GE56826
GO:0005096
GO:0005515
GO:0005576
GO:0005737
GO:0043087
GO:0098772
HMNXSV003022168
Hs.146220.0.A1_3p_at
ILMN_1803941
PH_hs_0039971
TC12000628.hg
TC12002446.hg
g12232450_3p_at
This entity regulates
Positively
TBC1D15 accelerates GTP hydrolysis by RAB7
(Homo sapiens)
Inferred To
GYP7 [cytosol]
(Saccharomyces cerevisiae)
Tbc1d15 [cytosol]
(Mus musculus)
Tbc1d15 [cytosol]
(Rattus norvegicus)
tbc-14 [cytosol]
(Caenorhabditis elegans)
gyp7 [cytosol]
(Schizosaccharomyces pombe)
tbc1d15 [cytosol]
(Xenopus tropicalis)
TBC1D15 [cytosol]
(Bos taurus)
TBC1D15 [cytosol]
(Canis familiaris)
TBC1D15 [cytosol]
(Dictyostelium discoideum)
TBC1D15 [cytosol]
(Gallus gallus)
TBC1D15 [cytosol]
(Sus scrofa)
Tbc1d15-17 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001139685.2
,
NP_001139686.1
,
NP_073608.4
OpenTargets
ENSG00000121749
HPA
ENSG00000121749-TBC1D15
GeneCards
Q8TC07
Ensembl
ENST00000550746
,
ENSP00000420678
,
ENSG00000121749
,
ENST00000485960
,
ENSP00000318262
,
ENSP00000448182
,
ENST00000319106
PRO
Q8TC07
Pharos - Targets
Q8TC07
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96CV9 OPTN
6
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [cytosol]
(R-HSA-9687907)
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
0.805
9
UniProt:Q96MT8 CEP63
1
CEP63 [cytosol]
(R-HSA-380267)
0.739
5
UniProt:O95166 GABARAP
3
GABARAP [autophagosome membrane]
(R-HSA-5683634)
GABARAP(1-117) [cytosol]
(R-HSA-5682696)
GABARAP [cytosol]
(R-HSA-975521)
0.591
5
UniProt:Q86VP1 TAX1BP1
1
TAX1BP1 [cytosol]
(R-HSA-937346)
0.556
3
UniProt:Q96MT8-3 CEP63
0.556
3
UniProt:Q9P1Z2 CACO1
0.556
3
UniProt:P60520 GABARAPL2
3
GABARAPL2 [autophagosome membrane]
(R-HSA-5683633)
GABARAPL2(1-117) [cytosol]
(R-HSA-5682641)
GABARAPL2 [cytosol]
(R-HSA-5671758)
0.544
2
UniProt:Q9H0R8 GABARAPL1
3
GABARAPL1 [autophagosome membrane]
(R-HSA-5683637)
GABARAPL1(1-117) [cytosol]
(R-HSA-5682659)
GABARAPL1 [cytosol]
(R-HSA-5671757)
0.544
2
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [cytosol]
(R-HSA-5205651)
0.544
2
UniProt:Q8NBM4 UBAC2
0.527
5
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
6
UniProt:P05919 vpu
6
VPU (P05919) protein [cytosol]
(R-HIV-173223)
VPU (P05919) [endoplasmic reticulum membrane]
(R-HIV-180550)
VPU (P05919) protein [extracellular region]
(R-HIV-175522)
VPU (P05919) protein [nucleoplasm]
(R-HIV-175200)
VPU (P05919) [Golgi membrane]
(R-HIV-3149439)
VPU (P05919) [plasma membrane]
(R-HIV-3149423)
0.462
2
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