Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-CHP1 [plasma membrane]
Stable Identifier
R-HSA-5333747
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
phosphorylated Calcineurin B homologous protein 1, CHP1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates and carbohydrate derivatives (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Hyaluronan metabolism (Homo sapiens)
Hyaluronan degradation (Homo sapiens)
HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ (Homo sapiens)
HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+ [plasma membrane] (Homo sapiens)
SLC9A1:p-CHP:Ca2+ [plasma membrane] (Homo sapiens)
p-CHP1:Ca2+ [plasma membrane] (Homo sapiens)
p-CHP1 [plasma membrane] (Homo sapiens)
SLC9A1:p-CHP:Ca2+ [plasma membrane] (Homo sapiens)
p-CHP1:Ca2+ [plasma membrane] (Homo sapiens)
p-CHP1 [plasma membrane] (Homo sapiens)
HYAL2 hydrolyses HA into 20kDa fragments (Homo sapiens)
HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+ [plasma membrane] (Homo sapiens)
SLC9A1:p-CHP:Ca2+ [plasma membrane] (Homo sapiens)
p-CHP1:Ca2+ [plasma membrane] (Homo sapiens)
p-CHP1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99653 CHP1
Gene Names
CHP1, CHP
Chain
initiator methionine:, chain:2-195
Reference Genes
BioGPS Gene:11261 CHP1
COSMIC (genes):CHP1 CHP1
CTD Gene:11261 CHP1
dbSNP Gene:11261 CHP1
ENSEMBL:ENSG00000187446 CHP1
HGNC:17433 CHP1
KEGG:hsa:11261 CHP1
Monarch:11261 CHP1
NCBI Gene:11261 CHP1
OMIM:606988 CHP1
UCSC:Q99653 CHP1
Reference Transcript
RefSeq:NM_007236.5 CHP1
Other Identifiers
11261
11754517_a_at
11756650_a_at
207993_PM_s_at
207993_s_at
214665_PM_s_at
214665_s_at
2862214
2934425
35018_at
3590342
3590343
3590347
3590348
3590349
3590352
3590353
3590355
3590356
3590359
3590360
3590361
3590362
3590363
3590364
3590366
3590367
3907071
49347_at
7982878
80180_at
84419_at
A_14_P116755
A_23_P100111
A_23_P112801
GE55456
GE59284
GO:0000139
GO:0001578
GO:0001933
GO:0004860
GO:0005215
GO:0005509
GO:0005515
GO:0005634
GO:0005737
GO:0005783
GO:0005793
GO:0005856
GO:0005886
GO:0005925
GO:0006355
GO:0006469
GO:0006611
GO:0006813
GO:0006886
GO:0006913
GO:0007010
GO:0007264
GO:0008017
GO:0008092
GO:0010923
GO:0012505
GO:0015031
GO:0015385
GO:0015459
GO:0015630
GO:0016020
GO:0019900
GO:0022406
GO:0030133
GO:0031122
GO:0031397
GO:0031410
GO:0031953
GO:0032088
GO:0032417
GO:0035725
GO:0042308
GO:0043226
GO:0045121
GO:0046872
GO:0048306
GO:0050821
GO:0051222
GO:0051453
GO:0055085
GO:0060050
GO:0061024
GO:0061025
GO:0070062
GO:0070885
GO:0071073
GO:0071468
GO:0090314
GO:0098772
GO:1990351
HMNXSV003016165
HMNXSV003035406
Hs.85301.3.S1_3p_s_at
ILMN_1779401
PH_hs_0030056
TC15000304.hg
U61538_at
g6005730_3p_a_at
Participates
as a component of
p-CHP1:Ca2+ [plasma membrane] (Homo sapiens)
Inferred To
phospho-chpf-1 [plasma membrane]
(Caenorhabditis elegans)
phospho-chp1 [plasma membrane]
(Xenopus tropicalis)
phospho-CHP1 [plasma membrane]
(Bos taurus)
phospho-CHP1 [plasma membrane]
(Gallus gallus)
phospho-CHP1 [plasma membrane]
(Sus scrofa)
phospho-p-CHP1 [plasma membrane]
(Canis familiaris)
phospho-Chp1 [plasma membrane]
(Mus musculus)
phospho-Chp1 [plasma membrane]
(Rattus norvegicus)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
NP_009167.1
ENSEMBL
ENST00000334660
,
ENSG00000187446
,
ENSP00000335632
OpenTargets
ENSG00000187446
GeneCards
CHP1
HPA
ENSG00000187446-CHP1
PRO
Q99653
Pharos - Targets
Q99653
GlyGen
Q99653
HMDB Protein
HMDBP02240
PDB
7DSV
,
7DSX
,
7X2U
,
2E30
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q86UL3 GPAT4
1
AGPAT6 [endoplasmic reticulum membrane]
(R-HSA-549099)
0.564
2
calcium(2+) [ChEBI:29108]
20
Ca2+ [endosome membrane]
(R-ALL-5210949)
Ca2+ [platelet dense granule lumen]
(R-ALL-114582)
Ca2+ [sarcoplasmic reticulum lumen]
(R-ALL-2855229)
Ca2+ [mitochondrial intermembrane space]
(R-ALL-8949232)
Ca2+ [lysosomal lumen]
(R-ALL-1606834)
Ca2+ [endocytic vesicle lumen]
(R-ALL-8851519)
Ca2+ [mitochondrial matrix]
(R-ALL-8949220)
Ca2+ [endoplasmic reticulum-Golgi intermediate compartment]
(R-ALL-9706979)
Ca2+ [Golgi lumen]
(R-ALL-167012)
Ca2+ [platelet dense tubular network lumen]
(R-ALL-139827)
Ca2+ [platelet dense tubular network membrane]
(R-ALL-141090)
Ca2+ [plasma membrane]
(R-ALL-140648)
Ca2+ [secretory granule lumen]
(R-ALL-216801)
Ca2+ [nuclear envelope]
(R-ALL-2318767)
Ca2+ [nucleoplasm]
(R-ALL-29496)
Ca2+ [mitochondrial inner membrane]
(R-ALL-1524102)
Ca2+ [endoplasmic reticulum membrane]
(R-ALL-1500625)
Ca2+ [cytosol]
(R-ALL-74016)
Ca2+ [extracellular region]
(R-ALL-74112)
Ca2+ [endoplasmic reticulum lumen]
(R-ALL-111875)
0.558
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
4
UniProt:P05919 vpu
6
VPU (P05919) protein [cytosol]
(R-HIV-173223)
VPU (P05919) [endoplasmic reticulum membrane]
(R-HIV-180550)
VPU (P05919) protein [extracellular region]
(R-HIV-175522)
VPU (P05919) protein [nucleoplasm]
(R-HIV-175200)
VPU (P05919) [Golgi membrane]
(R-HIV-3149439)
VPU (P05919) [plasma membrane]
(R-HIV-3149423)
0.462
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text