Reactome | TFG(1-193)-p-7Y-ALK(1058-1620) [cytosol]

TFG(1-193)-p-7Y-ALK(1058-1620) [cytosol]

Stable Identifier

R-HSA-9702029

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein TFG, TFG_HUMAN, TFGl

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
10556217	TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations Hernández, L, Pinyol, M, Hernández, S, Beà, S, Pulford, K, Rosenwald, A, Lamant, L, Falini, B, Ott, G, Mason, DY, Delsol, G, Campo, E	Blood	1999

External Reference Information

External Reference

UniProt:Q92734 TFG

Gene Names

TFG

Chain

chain:1-400

Reference Genes

BioGPS Gene:10342 Q05BK6

COSMIC (genes):TFG TFG

CTD Gene:10342 Q05BK6

dbSNP Gene:10342 Q05BK6

ENSEMBL:ENSG00000114354 TFG

HGNC:11758 TFG

KEGG:hsa:10342 TFG

Monarch:10342 Q05BK6

NCBI Gene:10342 Q05BK6

OMIM:602498 TFG

UCSC:Q92734 TFG

Reference Transcript

Other Identifiers

10342

11715598_at

16943375

217839_PM_at

217839_at

239385_PM_at

239385_at

244614_PM_at

244614_at

2633774

2633775

2633776

2633777

2633778

2633779

2633780

2633781

2633782

2633784

2633787

2633788

2633789

2633790

2633791

2633796

2633797

2633798

2633799

2633800

2633801

2633802

2633805

2633806

2633807

2633809

70744_at

77377_at

8081316

88110_at

A_14_P134937

A_14_P136435

A_23_P29517

A_24_P345822

GE61614

GE738883

GE85285

GO:0005515

GO:0005737

GO:0005783

GO:0005829

GO:0006888

GO:0016192

GO:0042802

GO:0043123

GO:0048208

GO:0065003

GO:0070971

HMNXSV003004113

HMNXSV003056027

Hs.142230.0.A1_3p_at

Hs.209245.0.A1_3p_at

ILMN_1779213

ILMN_1812474

ILMN_2341815

PH_hs_0026111

TC03000512.hg

g5174718_3p_at

Participates

as a component of

TFG(1-193)-p-7Y ALK(1058-1620) dimer [cytosol] (Homo sapiens)

Other forms of this molecule

TFG [cytosol]

TFG(1-240)-ALK(1058-1620) fusion [cytosol]

TFG(1-138)-ALK(1058-1620) fusion [cytosol]

TFG(1-193)-ALK(1058-1620) fusion [cytosol]

TFG(1-240)-p-7Y-ALK(1058-1620) fusion [cytosol]

TFG(1-138)-p-7Y-ALK(1058-1620) fusion [cytosol]

Modified Residues

Name

Insertion of residues 1058 to 1620 at 194 from UniProt:Q9UM73 ALK

Coordinate

194

Name

O4'-phospho-L-tyrosine at 1096

Coordinate

1096

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1278

Coordinate

1278

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1282

Coordinate

1282

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1283

Coordinate

1283

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1359

Coordinate

1359

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1507

Coordinate

1507

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1604

Coordinate

1604

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
anaplastic large cell lymphoma	DOID:0050744
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Cross References

RefSeq

XP_054200899.1, NP_001182407.1, XP_054200901.1, XP_054200896.1, XP_054200894.1, XP_016861019.1, XP_006713536.1, XP_006713535.1, XP_016861018.1, XP_016861016.1, NP_006061.2, XP_054200898.1, NP_001007566.1, NP_001182408.1, XP_005247123.1, XP_047303200.1, XP_016861017.1, XP_054200897.1, XP_047303199.1, XP_054200895.1, XP_047303197.1, XP_011510636.1, XP_047303198.1, XP_054200900.1

COSMIC

COSF430

OpenTargets

ENSG00000114354

ENSEMBL

ENSG00000114354, ENST00000674615, ENST00000240851, ENST00000674758, ENST00000620299, ENST00000675543, ENSP00000501892, ENST00000675553, ENST00000476228, ENSP00000419504, ENST00000463568, ENST00000615993, ENSP00000240851, ENSP00000419960, ENSP00000502139, ENSP00000502516, ENST00000676308, ENSP00000502697, ENSP00000420797, ENSP00000502698, ENSP00000479269, ENSP00000502071, ENST00000487505, ENSP00000502734, ENSP00000479981, ENSP00000502450, ENST00000490574, ENST00000675499, ENSP00000502497, ENST00000674645, ENST00000675047, ENSP00000417952, ENSP00000501815, ENST00000675586, ENST00000675420, ENSP00000502592, ENSP00000502502, ENST00000676395, ENST00000676111, ENST00000675243, ENSP00000502329, ENST00000676431, ENSP00000502229

Mondo

0020325

GeneCards

TFG

HPA

ENSG00000114354-TFG

PRO

Q92734

Pharos - Targets

Q92734

GlyGen

Q92734

Orphanet

TFG

PDB

8TEQ, 9E7C, 8TER

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.718	8
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.707	7
UniProt:P52597 HNRNPF	2	HNRNPF [nucleoplasm] (R-HSA-71937) HNRNPF [plasma membrane] (R-HSA-8950714)	0.556	3
UniProt:O75593 FOXH1	1	FOXH1 [nucleoplasm] (R-HSA-1225914)	0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:Q71SY5 MED25	1	MED25 [nucleoplasm] (R-HSA-212414)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q8TDS5 OXER1	1	OXER1 [plasma membrane] (R-HSA-416425)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.547	2
UniProt:P55735 SEC13	4	SEC13 [cytosol] (R-HSA-203981) SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994) SEC13 [lysosomal membrane] (R-HSA-9638246)	0.527	2
UniProt:O94979 SEC31A	5	SEC31A [ER to Golgi transport vesicle membrane] (R-HSA-204010) SEC31A [cytosol] (R-HSA-203983) SEC31A [endoplasmic reticulum membrane] (R-HSA-204000) SEC31A(1-989)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713478) SEC31A(1-989)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713475)	0.527	2