Reactome | ELOC [cytosol]

ELOC [cytosol]

Stable Identifier

R-HSA-180535

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TCEB1, Transcription elongation factor B polypeptide 1, RNA polymerase II transcription factor SIII subunit C, SIII p15, Elongin-C, EloC, Elongin 15 kDa subunit

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to hypoxia (Homo sapiens)
    - Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
      - Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
      - Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
      - Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
      - Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Homo sapiens)
        
        hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
      - Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
        
        hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
      - Proteasome proteolyzes ub-HIF-alpha (Homo sapiens)
        
        VBC complex (with or without LIMD1) [cytosol] (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
        
        ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Homo sapiens)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Homo sapiens)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15369 ELOC

Gene Names

ELOC, TCEB1

Chain

chain:1-112

Reference Genes

BioGPS Gene:6921 ELOC

COSMIC (genes):ELOC ELOC

CTD Gene:6921 ELOC

dbSNP Gene:6921 ELOC

ENSEMBL:ENSG00000154582.18 ELOC

HGNC:11617 ELOC

KEGG Gene (Homo sapiens):6921 ELOC

Monarch:6921 ELOC

NCBI Gene:6921 ELOC

OMIM:600788 ELOC

UCSC:Q15369 ELOC

Reference Transcript

Other Identifiers

0005900068

11744535_s_at

11744536_x_at

11759081_x_at

1399_at

17078342

17121176

202823_PM_at

202823_at

202824_PM_s_at

202824_s_at

3140836

3140837

3140838

3140839

3140840

3140841

3140843

3140844

3140847

3140850

3140855

3140856

3140857

3140858

3140859

3140860

3590502

3590503

6921

78247_at

8151413

8180298

A_23_P60028

A_24_P243881

GE61310

GE79008

GO:0001222

GO:0003746

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006367

GO:0006414

GO:0006511

GO:0016567

GO:0030163

GO:0030674

GO:0031462

GO:0031466

GO:0032991

GO:0036211

GO:0043226

GO:0045182

GO:0060090

GO:0070449

HMNXSV003052908

ILMN_1704873

ILMN_2066020

L34587_at

PH_hs_0037535

TC08001332.hg

g5032160_3p_a_at

Participates

as an output of

SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Homo sapiens)

as a component of

as an input of

SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 (Homo sapiens)

Other forms of this molecule

TCEB1 [nucleoplasm]

Inferred To

ELOC [cytosol] (Bos taurus)

ELOC [cytosol] (Canis familiaris)

ELOC [cytosol] (Danio rerio)

ELOC [cytosol] (Sus scrofa)

elc-1 [cytosol] (Caenorhabditis elegans)

tceb1b [cytosol] (Danio rerio)

TCEB1 [cytosol] (Gallus gallus)

Eloc [cytosol] (Mus musculus)

Eloc [cytosol] (Rattus norvegicus)

Homologues of ELOC [cytosol] (Danio rerio)

zgc:101879 [cytosol] (Danio rerio)

tceb1 [cytosol] (Dictyostelium discoideum)

EloC [cytosol] (Drosophila melanogaster)

eloc [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_005639.1, NP_001191789.1, NP_001191788.1, NP_001191786.1, NP_001191787.1, XP_011515883.1, NP_001191790.1, XP_011515882.1, NP_001191793.1, NP_001191791.1, NP_001191792.1

OpenTargets

ENSG00000154582

GeneCards

Q15369

HPA

ENSG00000154582-ELOC

Ensembl

ENST00000520210, ENSP00000430224, ENST00000519487, ENST00000520242, ENST00000522337, ENSP00000478121, ENSG00000154582, ENSP00000284811, ENST00000284811, ENST00000622804, ENST00000518127, ENSP00000428171, ENSP00000429596, ENSP00000428074, ENST00000523815, ENSP00000428334, ENSP00000429906

PRO

Q15369

Pharos - Targets

Q15369

PDB

6GMX, 6I7R, 4W9G, 3ZTD, 6FMK, 1LM8, 6P59, 6FMJ, 4AJY, 6GMR, 3ZTC, 5NVV, 7PLO, 4BKS, 6BVB, 6FMI, 6GMQ, 3DCG, 6R7N, 2C9W, 4W9K, 4W9C, 4W9D, 5NW2, 6V9H, 4WQO, 2IZV, 6R7H, 3ZKJ, 4W9I, 5NW1, 4W9J, 6C5X, 5NVZ, 6R7F, 6GFZ, 5NW0, 6HR2, 5NVY, 6GFY, 5NVX, 6ZHC, 6GFX, 4W9H, 4B9K, 3ZRF, 6I5N, 3ZUN, 7CJB, 4BKT, 5NVW, 3ZNG, 3ZRC, 7PI4, 6I5J, 4W9F, 6SIS, 7M6T, 4W9E, 7JTO, 6GMN, 7JTP, 4W9L, 6HAY, 1VCB, 4B95, 5LLI, 6I4X, 1LQB, 5T35, 4N9F, 7Q2J, 5BO4, 6HAX, 7KHH, 5N4W, 4AWJ, 2MA9

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15370 ELOB	2	TCEB2 [nucleoplasm] (R-HSA-112423) ELOB [cytosol] (R-HSA-180551)	0.952	20
UniProt:Q13617 CUL2	3	G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511) CUL2 [cytosol] (R-HSA-416982) CUL2 [nucleoplasm] (R-HSA-1234126)	0.802	10
UniProt:P40337 VHL	3	monoSUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697) VHL [nucleoplasm] (R-HSA-1234127) VHL [cytosol] (R-HSA-391423)	0.784	7
UniProt:Q5VZV1 MT21C			0.781	9
UniProt:Q16665 HIF1A	7	HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.702	5
UniProt:O15524 SOCS1	1	SOCS1 [cytosol] (R-HSA-204910)	0.678	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.643	7
UniProt:A0A663DJA2 ORF10			0.643	3
UniProt:O14508 SOCS2	1	SOCS2 [cytosol] (R-HSA-1169204)	0.573	2
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.564	5
UniProt:Q96A44 SPSB4	1	SPSB4 [cytosol] (R-HSA-976023)	0.564	2
UniProt:Q8N668 COMMD1	2	COMMD1 [nucleoplasm] (R-HSA-8955094) COMMD1 [cytosol] (R-HSA-8955110)	0.564	2
UniProt:Q99619 SPSB2	1	SPSB2 [cytosol] (R-HSA-976048)	0.564	3
UniProt:P12504 VIF			0.558	5
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q96G25 MED8	1	MED8 [nucleoplasm] (R-HSA-556784)	0.548	3
UniProt:P40337-3 VHL			0.547	2
UniProt:Q13618 CUL3	3	CUL3 [cytosol] (R-HSA-975979) CUL3 [nucleoplasm] (R-HSA-5635033) G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516)	0.547	3
UniProt:Q96DX5 ASB9	1	ASB9 [cytosol] (R-HSA-975424)	0.547	3
UniProt:P78395 PRAME			0.532	6
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.527	5
UniProt:Q9BQ90 KLHDC3	1	KLHDC3 [cytosol] (R-HSA-535552)	0.527	3
UniProt:Q9NWX5 ASB6	1	ASB6 [cytosol] (R-HSA-975412)	0.527	3
UniProt:Q96S21 RAB40C	2	GGC-RAB40C [cytosol] (R-HSA-8874025) RAB40C [cytosol] (R-HSA-8873693)	0.525	2

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