Reactome | ELOC [cytosol]

ELOC [cytosol]

Stable Identifier

R-HSA-180535

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TCEB1, Transcription elongation factor B polypeptide 1, RNA polymerase II transcription factor SIII subunit C, SIII p15, Elongin-C, EloC, Elongin 15 kDa subunit

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to hypoxia (Homo sapiens)
    - Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
      - Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
      - Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
      - Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
      - Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Homo sapiens)
        
        hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
      - Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
        
        hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
      - Proteasome proteolyzes ub-HIF-alpha (Homo sapiens)
        
        VBC complex (with or without LIMD1) [cytosol] (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
        
        ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Homo sapiens)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
        
        PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Homo sapiens)
        
        ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
        
        RBX1-CUL2-EloB,C-VHL [cytosol] (Homo sapiens)
        
        VBC complex [cytosol] (Homo sapiens)
        
        ELOC [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15369 ELOC

Gene Names

ELOC, TCEB1

Chain

chain:1-112

Reference Genes

BioGPS Gene:6921 ELOC

COSMIC (genes):ELOC ELOC

CTD Gene:6921 ELOC

dbSNP Gene:6921 ELOC

ENSEMBL:ENSG00000154582 ELOC

HGNC:11617 ELOC

KEGG Gene (Homo sapiens):6921 ELOC

Monarch:6921 ELOC

NCBI Gene:6921 ELOC

OMIM:600788 ELOC

UCSC:Q15369 ELOC

Reference Transcript

Other Identifiers

0005900068

11744535_s_at

11744536_x_at

11759081_x_at

1399_at

17078342

17121176

202823_at

202824_s_at

3140836

3140837

3140838

3140839

3140840

3140841

3140844

3140847

3140850

3140855

3140856

3140857

3140858

3140859

3140860

3590502

3590503

6921

78247_at

8151413

8180298

A_23_P60028

A_24_P243881

GE61310

GE79008

GO:0003674

GO:0003723

GO:0003746

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006357

GO:0006366

GO:0006368

GO:0006412

GO:0006414

GO:0006464

GO:0006511

GO:0006950

GO:0008135

GO:0008150

GO:0009056

GO:0009058

GO:0016032

GO:0016567

GO:0031462

GO:0032991

GO:0034641

GO:0043226

GO:0043687

GO:0044403

GO:0061418

GO:0070449

HMNXSV003052908

ILMN_1704873

ILMN_2066020

L34587_at

PH_hs_0037535

TC08001332.hg

g5032160_3p_a_at

Participates

as a component of

as an output of

SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Homo sapiens)

as an input of

SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 (Homo sapiens)

Other forms of this molecule

TCEB1 [nucleoplasm]

Inferred To

ELC1 [cytosol] (Saccharomyces cerevisiae)

ELOC [cytosol] (Bos taurus)

ELOC [cytosol] (Canis familiaris)

ELOC [cytosol] (Danio rerio)

ELOC [cytosol] (Sus scrofa)

elc1 [cytosol] (Schizosaccharomyces pombe)

elc-1 [cytosol] (Caenorhabditis elegans)

TCEB1 [cytosol] (Gallus gallus)

Eloc [cytosol] (Mus musculus)

Eloc [cytosol] (Rattus norvegicus)

Homologues of ELOC [cytosol] (Danio rerio)

eloca [cytosol] (Danio rerio)

tceb1 [cytosol] (Dictyostelium discoideum)

elocb [cytosol] (Danio rerio)

EloC [cytosol] (Drosophila melanogaster)

eloc [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001191790.1, NP_001191793.1, NP_001191792.1, NP_001191786.1, NP_001191788.1, NP_001191791.1, NP_005639.1, NP_001191789.1, NP_001191787.1, XP_011515883.1, XP_011515882.1

OpenTargets

ENSG00000154582

GeneCards

Q15369

HPA

ENSG00000154582-ELOC

Ensembl

ENSP00000428171, ENSP00000428074, ENSP00000429596, ENST00000518127, ENSP00000478121, ENSP00000428334, ENST00000520242, ENSP00000429906, ENSP00000430224, ENST00000522337, ENST00000520210, ENST00000523815, ENST00000519487, ENSP00000284811, ENSG00000154582, ENST00000284811, ENST00000622804

PRO

Q15369

Pharos - Targets

Q15369

GlyGen

Q15369

PDB

6R7N, 4W9D, 6GMN, 4W9E, 5NVV, 6GMQ, 5BO4, 6R7H, 6R7F, 4W9J, 6HAY, 4W9C, 6SIS, 4W9K, 4AWJ, 6GFY, 6I7R, 3ZNG, 6FMK, 5NW0, 5NVZ, 6C5X, 5NW1, 4BKT, 6GFZ, 3ZTD, 1LQB, 6FMI, 4W9F, 6V9H, 1LM8, 4W9G, 3ZTC, 3DCG, 6GFX, 6P59, 7KHH, 4W9L, 3ZKJ, 2MA9, 6BVB, 4B95, 6I4X, 6HAX, 4BKS, 4B9K, 4WQO, 5LLI, 5NW2, 2C9W, 6ZHC, 3ZUN, 4W9H, 5NVY, 4AJY, 5T35, 3ZRC, 5N4W, 4W9I, 6HR2, 2IZV, 4N9F, 1VCB, 6GMR, 6FMJ, 6I5J, 5NVW, 5NVX, 3ZRF, 6GMX, 6I5N

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15370 ELOB	2	ELOB [cytosol] (R-HSA-180551) TCEB2 [nucleoplasm] (R-HSA-112423)	0.952	20
UniProt:Q13617 CUL2	3	G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511) CUL2 [cytosol] (R-HSA-416982) CUL2 [nucleoplasm] (R-HSA-1234126)	0.802	10
UniProt:P40337 VHL	3	VHL [nucleoplasm] (R-HSA-1234127) VHL [cytosol] (R-HSA-391423) SUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697)	0.784	7
UniProt:Q5VZV1 MT21C			0.781	9
UniProt:Q16665 HIF1A	7	p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) 2xHP-HIF1A [cytosol] (R-HSA-1234131) HIF1A [cytosol] (R-HSA-1234102) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HIF1A [nucleoplasm] (R-HSA-1234135) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HN-HIF1A [cytosol] (R-HSA-1234110)	0.702	5
UniProt:O15524 SOCS1	1	SOCS1 [cytosol] (R-HSA-204910)	0.678	4
UniProt:P13569 CFTR	17	CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR [plasma membrane] (R-HSA-383188) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR [endosome membrane] (R-HSA-6782965) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) CFTR N1303K [plasma membrane] (R-HSA-5678983) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) ub-CFTR F508del [cytosol] (R-HSA-8866838) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.643	7
UniProt:O14508 SOCS2	1	SOCS2 [cytosol] (R-HSA-1169204)	0.573	2
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.564	5
UniProt:Q96A44 SPSB4	1	SPSB4 [cytosol] (R-HSA-976023)	0.564	2
UniProt:Q8N668 COMMD1	2	COMMD1 [nucleoplasm] (R-HSA-8955094) COMMD1 [cytosol] (R-HSA-8955110)	0.564	2
UniProt:Q99619 SPSB2	1	SPSB2 [cytosol] (R-HSA-976048)	0.564	3
UniProt:P12504 VIF			0.558	5
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q96G25 MED8	1	MED8 [nucleoplasm] (R-HSA-556784)	0.548	3
UniProt:P40337-3 VHL			0.547	2
UniProt:Q13618 CUL3	3	CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979) G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516)	0.547	3
UniProt:Q96DX5 ASB9	1	ASB9 [cytosol] (R-HSA-975424)	0.547	3
UniProt:P78395 PRAME			0.532	6
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.527	5
UniProt:Q9BQ90 KLHDC3	1	KLHDC3 [cytosol] (R-HSA-535552)	0.527	3
UniProt:Q9NWX5 ASB6	1	ASB6 [cytosol] (R-HSA-975412)	0.527	3
UniProt:A0A663DJA2 A0A663DJA2			0.527	2
UniProt:Q96S21 RAB40C	2	RAB40C [cytosol] (R-HSA-8873693) GGC-RAB40C [cytosol] (R-HSA-8874025)	0.525	2

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