Reactome | VTN [extracellular region]

VTN [extracellular region]

Stable Identifier

R-HSA-215971

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Vitronectin

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P04004 VTN

Gene Names

VTN

Chain

signal peptide:1-19, chain:20-478, chain:20-398, peptide:20-63, chain:399-478

Reference Genes

BioGPS Gene:7448 VTN

COSMIC (genes):VTN VTN

CTD Gene:7448 VTN

dbSNP Gene:7448 VTN

ENSEMBL:ENSG00000109072 VTN

HGNC:12724 VTN

KEGG Gene (Homo sapiens):7448 VTN

Monarch:7448 VTN

NCBI Gene:7448 VTN

OMIM:193190 VTN

UCSC:P04004 VTN

Reference Transcript

RefSeq:NM_000638.3 VTN

Other Identifiers

0004050333

11757862_x_at

11757900_a_at

16842602

204534_3p_at

204534_at

33377_at

3750663

3750664

3750665

3750666

3750668

3750670

3750671

3750673

3750674

3750675

3750676

3750677

3750678

3750679

7448

8013606

A_23_P78099

GE59648

GO:0002376

GO:0003674

GO:0005044

GO:0005178

GO:0005198

GO:0005201

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005886

GO:0006464

GO:0006810

GO:0006897

GO:0006950

GO:0006955

GO:0007155

GO:0007160

GO:0007165

GO:0008150

GO:0008201

GO:0009790

GO:0010951

GO:0014911

GO:0016192

GO:0016477

GO:0020003

GO:0030154

GO:0030195

GO:0030198

GO:0030247

GO:0030449

GO:0030949

GO:0031012

GO:0032092

GO:0032991

GO:0033627

GO:0035987

GO:0040011

GO:0043167

GO:0043226

GO:0043231

GO:0048260

GO:0048646

GO:0048856

GO:0048870

GO:0050731

GO:0061302

GO:0062023

GO:0070062

GO:0071062

GO:0072562

GO:0090303

ILMN_1691127

PH_hs_0000304

TC17001296.hg

X03168_at

g10835190_3p_at

g10835190_3p_s_at

Participant Of

hasComponent

input

hasMember

Elastic fibre-asociated proteins [extracellular region]

Inferred To

VTN [extracellular region] (Canis familiaris)

VTN [extracellular region] (Gallus gallus)

VTN [extracellular region] (Sus scrofa)

vtn [extracellular region] (Xenopus tropicalis)

EG:8D8.2 [extracellular region] (Drosophila melanogaster)

vtnb [extracellular region] (Danio rerio)

Vtn [extracellular region] (Mus musculus)

Vtn [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_000629.3

OpenTargets

ENSG00000109072

GeneCards

P04004

HPA

ENSG00000109072-VTN

Ensembl

ENSP00000226218, ENSG00000109072, ENST00000226218

PRO

P04004

PDB

2JQ8, 3BT2, 6O5E, 1SSU, 1OC0, 1S4G, 4K24, 3BT1

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07021 C1QBP	3	C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123) C1QBP [cytosol] (R-HSA-9645690)	0.702	9
UniProt:Q9HD26 GOPC	3	GOPC [plasma membrane] (R-HSA-5626572) GOPC [lysosomal membrane] (R-HSA-5627281) GOPC [Golgi-associated vesicle membrane] (R-HSA-5627067)	0.666	4
UniProt:Q4KTX9 Q4KTX9			0.602	12
UniProt:A0A024A2C9 A0A024A2C9			0.602	7
UniProt:P18084 ITGB5	2	ITGB5 [plasma membrane] (R-HSA-215948) ITGB5 [phagocytic vesicle] (R-HSA-1236749)	0.564	2
UniProt:Q9NSN8 SNTG1			0.556	3
UniProt:Q92796 DLG3	2	DLG3 [cytosol] (R-HSA-6794232) DLG3 [plasma membrane] (R-HSA-443609)	0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:Q9HD26-2 GOPC			0.556	3
UniProt:Q15700 DLG2	2	DLG2 [plasma membrane] (R-HSA-9610662) DLG2 [cytosol] (R-HSA-6794230)	0.556	3
UniProt:Q96PY6 NEK1			0.508	2
UniProt:C5MHM7 C5MHM7			0.462	2
UniProt:G8BA52 G8BA52			0.462	2
UniProt:G8BE22 G8BE22			0.462	2
UniProt:G8BFS5 G8BFS5			0.462	2
UniProt:G8BCH3 G8BCH3			0.462	2
UniProt:G8B999 G8B999			0.462	2

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