Reactome | VTN [extracellular region]

VTN [extracellular region]

Stable Identifier

R-HSA-215971

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Vitronectin

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P04004 VTN

Gene Names

VTN

Chain

signal peptide:1-19, chain:20-478, chain:20-398, peptide:20-63, chain:399-478

Reference Genes

BioGPS Gene:7448 VTN

COSMIC (genes):VTN VTN

CTD Gene:7448 VTN

dbSNP Gene:7448 VTN

ENSEMBL:ENSG00000109072 VTN

HGNC:12724 VTN

KEGG:hsa:7448 VTN

Monarch:7448 VTN

NCBI Gene:7448 VTN

OMIM:193190 VTN

UCSC:P04004 VTN

Reference Transcript

RefSeq:NM_000638.3 VTN

Other Identifiers

11757862_x_at

11757900_a_at

16842602

204534_3p_at

204534_PM_at

204534_at

33377_at

3750663

3750664

3750665

3750666

3750668

3750669

3750670

3750671

3750672

3750673

3750674

3750675

3750676

3750677

3750678

3750679

7448

8013606

A_23_P78099

GE59648

GO:0002376

GO:0005044

GO:0005178

GO:0005198

GO:0005201

GO:0005515

GO:0005518

GO:0005576

GO:0005604

GO:0005615

GO:0005783

GO:0005796

GO:0006955

GO:0007155

GO:0007160

GO:0008201

GO:0010811

GO:0010951

GO:0014911

GO:0016192

GO:0016477

GO:0030154

GO:0030155

GO:0030195

GO:0030198

GO:0030247

GO:0030312

GO:0030949

GO:0031012

GO:0032092

GO:0033627

GO:0035987

GO:0038024

GO:0042802

GO:0043226

GO:0043231

GO:0048237

GO:0048260

GO:0048709

GO:0048856

GO:0048870

GO:0050731

GO:0050840

GO:0051258

GO:0051918

GO:0061302

GO:0062023

GO:0065003

GO:0070062

GO:0071062

GO:0072562

GO:0090303

GO:0097421

GO:0098637

GO:1904090

HMNXSV003052259

ILMN_1691127

PH_hs_0000304

TC17001296.hg

X03168_at

g10835190_3p_at

g10835190_3p_s_at

Participates

as a component of

as an input of

as a member of

Elastic fibre-asociated proteins [extracellular region] (Homo sapiens)

as a candidate of

(FN1 dimer, VTN) [extracellular region] (Homo sapiens)

Inferred To

SEBOX [extracellular region] (Canis familiaris)

vtna [extracellular region] (Danio rerio)

Homologues of VTN [extracellular region] (Drosophila melanogaster)

VTN [extracellular region] (Bos taurus)

VTN [extracellular region] (Gallus gallus)

VTN [extracellular region] (Sus scrofa)

vtn [extracellular region] (Xenopus tropicalis)

EG:8D8.2 [extracellular region] (Drosophila melanogaster)

anon-WO0140519.208 [extracellular region] (Drosophila melanogaster)

Vtn [extracellular region] (Mus musculus)

Vtn [extracellular region] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000109072

ENSEMBL

ENSP00000226218, ENST00000226218, ENSG00000109072

GeneCards

VTN

HPA

ENSG00000109072-VTN

PRO

P04004

Pharos - Targets

P04004

GlyGen

P04004

PDB

7RJ9, 1S4G, 1SSU, 3BT2, 1OC0, 3BT1, 4K24, 2JQ8, 6O5E

Interactors (41)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.767	10
UniProt:Q9HD26 GOPC	3	GOPC [Golgi-associated vesicle membrane] (R-HSA-5627067) GOPC [plasma membrane] (R-HSA-5626572) GOPC [lysosomal membrane] (R-HSA-5627281)	0.666	4
UniProt:A0A024A2C9 A0A024A2C9			0.602	7
UniProt:Q4KTX9 Q4KTX9			0.602	12
UniProt:Q92796 DLG3	2	DLG3 [plasma membrane] (R-HSA-443609) DLG3 [cytosol] (R-HSA-6794232)	0.556	3
UniProt:Q15700 DLG2	2	DLG2 [plasma membrane] (R-HSA-9610662) DLG2 [cytosol] (R-HSA-6794230)	0.556	3
UniProt:Q9NSN8 SNTG1			0.556	3
UniProt:Q9HD26-2 GOPC			0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:Q7Z2K8 GPRIN1	1	GPRIN1 [plasma membrane] (R-HSA-9022059)	0.527	2
UniProt:Q9BZF9 UACA	1	UACA [cytosol] (R-HSA-6804636)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.527	8
UniProt:Q14CZ7 FAKD3			0.527	2
UniProt:Q14999 CUL7	1	CUL7 [cytosol] (R-HSA-535534)	0.527	2
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.527	2
UniProt:P18084 ITGB5	2	ITGB5 [phagocytic vesicle] (R-HSA-1236749) ITGB5 [plasma membrane] (R-HSA-215948)	0.527	2
UniProt:Q8TF39 ZNF483	1	ZNF483 [nucleoplasm] (R-HSA-1247869)	0.527	2
UniProt:Q8WV60 PTCD2			0.527	2
UniProt:Q7Z6M2 FBX33			0.527	2
UniProt:Q01804 OTUD4			0.527	2
UniProt:P10075 GLI4			0.527	2
UniProt:Q9HD23 MRS2	1	MRS2 [mitochondrial inner membrane] (R-HSA-5216072)	0.527	2
UniProt:P17482 HXB9			0.527	2
UniProt:Q9C0J8 WDR33	1	WDR33 [nucleoplasm] (R-HSA-8938784)	0.527	2
UniProt:Q6P1A2 LPCAT3	1	LPCAT3 [endoplasmic reticulum membrane] (R-HSA-428994)	0.527	2
UniProt:O95707 POP4	1	POP4 [nucleoplasm] (R-HSA-5696789)	0.527	2
UniProt:P55209 NP1L1			0.527	2
UniProt:Q96CN7 ISOC1			0.527	2
UniProt:Q9ULD5 ZNF777	1	ZNF777 [nucleoplasm] (R-HSA-3110238)	0.527	2
UniProt:Q9UBS8 RNF14	1	RNF14 [cytosol] (R-HSA-5688974)	0.527	2
UniProt:P56182 RRP1	1	RRP1 [nucleoplasm] (R-HSA-6792441)	0.527	2
UniProt:Q9UH62 ARMCX3	1	ARMCX3 [mitochondrial outer membrane] (R-HSA-9714514)	0.527	2
UniProt:Q9H7X3 ZNF696	1	ZNF696 [nucleoplasm] (R-HSA-2454138)	0.527	2
UniProt:O43822 CF410			0.508	2
UniProt:Q96PY6 NEK1	1	NEK1 [cytosol] (R-HSA-9861542)	0.508	2
UniProt:G8BCH3 G8BCH3			0.462	2
UniProt:G8BFS5 G8BFS5			0.462	2
UniProt:G8BE22 G8BE22			0.462	2
UniProt:G8B999 G8B999			0.462	2
UniProt:G8BA52 G8BA52			0.462	2
UniProt:C5MHM7 C5MHM7			0.462	2

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