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VTN [extracellular region]
Stable Identifier
R-HSA-215971
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Vitronectin
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
ECM proteoglycans (Homo sapiens)
VTN binds Plasminogen activator inhibitor- 1 (Homo sapiens)
VTN [extracellular region] (Homo sapiens)
Vitronectin:Plasminogen activator inhibitor 1 [extracellular region] (Homo sapiens)
VTN [extracellular region] (Homo sapiens)
VTN binds collagens I, IV and VI (Homo sapiens)
VTN [extracellular region] (Homo sapiens)
VTN:Collagen type I,IV,VI [extracellular region] (Homo sapiens)
VTN [extracellular region] (Homo sapiens)
VTN binds collagens II, III and V (Homo sapiens)
VTN [extracellular region] (Homo sapiens)
VTN:Collagen types II,III,V [extracellular region] (Homo sapiens)
VTN [extracellular region] (Homo sapiens)
VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Homo sapiens)
VTN [extracellular region] (Homo sapiens)
VTN:Integrins alphaVbeta1, alphaVbeta3, alphaVbeta5, alpha2bbeta3 [plasma membrane] (Homo sapiens)
VTN [extracellular region] (Homo sapiens)
Elastic fibre formation (Homo sapiens)
Molecules associated with elastic fibres (Homo sapiens)
Elastic fibres bind associated proteins (Homo sapiens)
Elastic fibre with associated proteins [extracellular region] (Homo sapiens)
Elastic fibre-asociated proteins [extracellular region] (Homo sapiens)
VTN [extracellular region] (Homo sapiens)
Elastic fibre-asociated proteins [extracellular region] (Homo sapiens)
VTN [extracellular region] (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Homo sapiens)
VTN [extracellular region] (Homo sapiens)
VTN:Integrin alphaVbeta3, 5, 8 [plasma membrane] (Homo sapiens)
VTN [extracellular region] (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Syndecan interactions (Homo sapiens)
Syndecans 1, 2 & 4 bind VTN (Homo sapiens)
Syndecan-1, 2 & 4:VTN [plasma membrane] (Homo sapiens)
VTN [extracellular region] (Homo sapiens)
VTN [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
Formation of soluble VTN:C5b-C9 (Homo sapiens)
VTN:C5b:C6:C7 [extracellular region] (Homo sapiens)
VTN [extracellular region] (Homo sapiens)
VTN:C5b:C6:C7:C8:C9 [extracellular region] (Homo sapiens)
VTN:C5b:C6:C7 [extracellular region] (Homo sapiens)
VTN [extracellular region] (Homo sapiens)
Vitronectin (VTN) binds to C5b:C6:C7 (Homo sapiens)
VTN [extracellular region] (Homo sapiens)
VTN:C5b:C6:C7 [extracellular region] (Homo sapiens)
VTN [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04004 VTN
Gene Names
VTN
Chain
signal peptide:1-19, chain:20-478, chain:20-398, peptide:20-63, chain:399-478
Reference Genes
BioGPS Gene:7448 VTN
COSMIC (genes):VTN VTN
CTD Gene:7448 VTN
dbSNP Gene:7448 VTN
ENSEMBL:ENSG00000109072 VTN
ENSEMBL_homo_sapiens_GENE:ENSG00000109072.14 VTN
HGNC:12724 VTN
KEGG Gene (Homo sapiens):7448 VTN
Monarch:7448 VTN
NCBI Gene:7448 VTN
OMIM:193190 VTN
UCSC:P04004 VTN
Reference Transcript
RefSeq:NM_000638.3 VTN
Other Identifiers
11757862_x_at
11757900_a_at
16842602
204534_3p_at
204534_PM_at
204534_at
33377_at
3750663
3750664
3750665
3750666
3750668
3750670
3750671
3750673
3750674
3750675
3750676
3750677
3750678
3750679
7448
8013606
A_23_P78099
GE59648
GO:0002376
GO:0005044
GO:0005178
GO:0005198
GO:0005201
GO:0005515
GO:0005518
GO:0005576
GO:0005604
GO:0005615
GO:0005783
GO:0005794
GO:0005796
GO:0005886
GO:0006897
GO:0006955
GO:0007155
GO:0007160
GO:0008201
GO:0010811
GO:0010951
GO:0014911
GO:0016192
GO:0016477
GO:0020003
GO:0023052
GO:0030154
GO:0030155
GO:0030195
GO:0030198
GO:0030247
GO:0030312
GO:0030949
GO:0031012
GO:0032092
GO:0033627
GO:0035987
GO:0036211
GO:0038024
GO:0042060
GO:0042802
GO:0043226
GO:0043231
GO:0048237
GO:0048260
GO:0048709
GO:0048856
GO:0048870
GO:0050731
GO:0050840
GO:0051258
GO:0051918
GO:0061302
GO:0062023
GO:0065003
GO:0070062
GO:0071062
GO:0072562
GO:0090303
GO:0097421
GO:0098637
GO:0110165
GO:1904090
HMNXSV003052259
ILMN_1691127
PH_hs_0000304
TC17001296.hg
X03168_at
g10835190_3p_at
g10835190_3p_s_at
Participates
as a component of
VTN:Collagens I, IV, VI [extracellular region] (Rattus norvegicus)
VTN:Collagen type I,IV,VI [extracellular region] (Homo sapiens)
VTN:Collagen types II,III,V [extracellular region] (Homo sapiens)
Vitronectin:Plasminogen activator inhibitor 1 [extracellular region] (Homo sapiens)
VTN:Integrins alphaVbeta1, alphaVbeta3, alphaVbeta5, alpha2bbeta3 [plasma membrane] (Homo sapiens)
Syndecan-1, 2 & 4:VTN [plasma membrane] (Homo sapiens)
VTN:Integrin alphaVbeta3, 5, 8 [plasma membrane] (Homo sapiens)
VTN:C5b:C6:C7 [extracellular region] (Homo sapiens)
as an input of
VTN binds collagen I, IV and VI (Homo sapiens)
VTN binds collagens I, IV and VI (Homo sapiens)
VTN binds collagens II, III and V (Homo sapiens)
VTN binds Plasminogen activator inhibitor- 1 (Homo sapiens)
VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3 (Homo sapiens)
Syndecans 1, 2 & 4 bind VTN (Homo sapiens)
VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 (Homo sapiens)
Vitronectin (VTN) binds to C5b:C6:C7 (Homo sapiens)
as a member of
Elastic fibre-asociated proteins [extracellular region] (Homo sapiens)
Inferred To
Homologues of VTN [extracellular region]
(Drosophila melanogaster)
VTN [extracellular region]
(Bos taurus)
VTN [extracellular region]
(Canis familiaris)
VTN [extracellular region]
(Gallus gallus)
VTN [extracellular region]
(Sus scrofa)
vtn [extracellular region]
(Xenopus tropicalis)
EG:8D8.2 [extracellular region]
(Drosophila melanogaster)
anon-WO0140519.208 [extracellular region]
(Drosophila melanogaster)
zgc:112277 [extracellular region]
(Danio rerio)
Vtn [extracellular region]
(Mus musculus)
Vtn [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_000629.3
OpenTargets
ENSG00000109072
HPA
ENSG00000109072-VTN
GeneCards
P04004
Ensembl
ENSG00000109072
,
ENSP00000226218
,
ENST00000226218
PRO
P04004
Pharos - Targets
P04004
PDB
1S4G
,
3BT1
,
7RJ9
,
1SSU
,
4K24
,
6O5E
,
2JQ8
,
3BT2
,
1OC0
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q07021 C1QBP
3
C1QBP [plasma membrane]
(R-HSA-158123)
C1QBP [mitochondrial matrix]
(R-HSA-9645697)
C1QBP [cytosol]
(R-HSA-9645690)
0.702
9
UniProt:Q9HD26 GOPC
3
GOPC [lysosomal membrane]
(R-HSA-5627281)
GOPC [plasma membrane]
(R-HSA-5626572)
GOPC [Golgi-associated vesicle membrane]
(R-HSA-5627067)
0.666
4
UniProt:A0A024A2C9 A0A024A2C9
0.602
7
UniProt:Q4KTX9 Q4KTX9
0.602
12
UniProt:Q92796 DLG3
2
DLG3 [plasma membrane]
(R-HSA-443609)
DLG3 [cytosol]
(R-HSA-6794232)
0.556
3
UniProt:Q15700 DLG2
2
DLG2 [plasma membrane]
(R-HSA-9610662)
DLG2 [cytosol]
(R-HSA-6794230)
0.556
3
UniProt:Q9HD26-2 GOPC
0.556
3
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
UniProt:Q9NSN8 SNTG1
0.556
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.527
8
UniProt:Q96PY6 NEK1
1
NEK1 [cytosol]
(R-HSA-9861542)
0.508
2
UniProt:C5MHM7 C5MHM7
0.462
2
UniProt:G8BA52 G8BA52
0.462
2
UniProt:G8B999 G8B999
0.462
2
UniProt:G8BCH3 G8BCH3
0.462
2
UniProt:G8BFS5 G8BFS5
0.462
2
UniProt:G8BE22 G8BE22
0.462
2
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