Reactome | Polyglutamyl-TUBAL3 [cytosol]

Polyglutamyl-TUBAL3 [cytosol]

Stable Identifier

R-HSA-8867416

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TUBAL3, Tubulin alpha chain-like 3, TBAL3_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
    - CCPs deglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBAL3 [cytosol] (Homo sapiens)
    - Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBAL3 [cytosol] (Homo sapiens)
    - TTLLs polyglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBAL3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:A6NHL2 TUBAL3

Gene Names

TUBAL3

Chain

chain:1-446

Reference Genes

BioGPS Gene:79861 TUBAL3

COSMIC (genes):TUBAL3 TUBAL3

CTD Gene:79861 TUBAL3

dbSNP Gene:79861 TUBAL3

ENSEMBL:ENSG00000178462 TUBAL3

ENSEMBL_homo_sapiens_GENE:ENSG00000178462.12 TUBAL3

HGNC:23534 TUBAL3

KEGG Gene (Homo sapiens):79861 TUBAL3

Monarch:79861 TUBAL3

NCBI Gene:79861 TUBAL3

UCSC:A6NHL2 TUBAL3

Reference Transcript

Other Identifiers

11740334_at

16711383

220310_PM_at

220310_at

3274899

3274900

3274901

3274903

3274904

3274905

3274906

7931852

79861

A_23_P95851

A_33_P3332252

GE62960

GO:0000166

GO:0000226

GO:0000278

GO:0003824

GO:0005198

GO:0005200

GO:0005525

GO:0005737

GO:0005856

GO:0005874

GO:0007010

GO:0007017

GO:0015630

GO:0016787

GO:0043226

GO:0046872

HMNXSV003050473

ILMN_1670385

PH_hs_0009873

TC10000993.hg

g13376180_3p_at

Participates

as a candidate of

Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)

Other forms of this molecule

AcK-TUBAL3 [cytosol]

TUBAL3 folding intermediate [cytosol]

TUBAL3 unfolded [cytosol]

L-isoglutamyl polyglycyl-TUBAL3 [cytosol]

TUBAL3 [cytosol]

Inferred To

Homologues of Polyglutamyl-TUBAL3 [cytosol] (Dictyostelium discoideum)

Homologues of Polyglutamyl-TUBAL3 [cytosol] (Plasmodium falciparum)

Polyglutamyl-TUBAL3 [cytosol] (Dictyostelium discoideum)

Polyglutamyl-TUBAL3 [cytosol] (Mus musculus)

Polyglutamyl-TUBAL3 [cytosol] (Plasmodium falciparum)

Polyglutamyl-TUBAL3 [cytosol] (Sus scrofa)

TUBAL3 [cytosol] (Bos taurus)

TUBAL3 [cytosol] (Canis familiaris)

Tubal3 [cytosol] (Rattus norvegicus)

Modified Residues

Name

L-isoglutamyl-polyglutamic acid at unknown position

PsiMod Name

L-isoglutamyl-polyglutamic acid

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid.

Cross References

RefSeq

NP_001165335.1, NP_079079.1

OpenTargets

ENSG00000178462

HPA

ENSG00000178462-TUBAL3

GeneCards

A6NHL2

Ensembl

ENSP00000418799, ENST00000380419, ENSG00000178462, ENST00000479328, ENSP00000369784

PRO

A6NHL2

Pharos - Targets

A6NHL2

HMDB Protein

HMDBP08600

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6