Reactome | RAB7A [cytosol]

RAB7A [cytosol]

Stable Identifier

R-HSA-8870415

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ras-related protein Rab-7a, RAB7A_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Bacterial Infection Pathways (Homo sapiens)
    - Infection with Mycobacterium tuberculosis (Homo sapiens)
      - Response of Mtb to phagocytosis (Homo sapiens)
        
        Suppression of phagosomal maturation (Homo sapiens)
        
        Prevention of phagosomal-lysosomal fusion (Homo sapiens)
        
        NdkA dephosphorylates RAB5A:GTP,RAB7A:GTP (Homo sapiens)
        
        RAB5A,RAB7A:GDP [cytosol] (Homo sapiens)
        
        RAB5A,RAB7A [cytosol] (Homo sapiens)
        
        RAB7A [cytosol] (Homo sapiens)
        
        RAB5A:GTP,RAB7A:GTP [cytosol] (Homo sapiens)
        
        RAB5A,RAB7A [cytosol] (Homo sapiens)
        
        RAB7A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P51149 RAB7A

Gene Names

RAB7A, RAB7

Chain

initiator methionine:, chain:2-207

Reference Genes

BioGPS Gene:7879 RAB7A

COSMIC (genes):RAB7A RAB7A

CTD Gene:7879 RAB7A

dbSNP Gene:7879 RAB7A

ENSEMBL:ENSG00000075785 RAB7A

HGNC:9788 RAB7A

KEGG:hsa:7879 RAB7A

Monarch:7879 RAB7A

NCBI Gene:7879 RAB7A

OMIM:602298 RAB7A

UCSC:P51149 RAB7A

Reference Transcript

RefSeq:NM_004637.5 RAB7A

Other Identifiers

11722811_s_at

11722812_s_at

11753390_x_at

1570061_PM_at

1570061_at

16945241

211960_PM_s_at

211960_s_at

211961_PM_s_at

211961_s_at

2641264

2641283

2641284

2641285

2641286

2641287

2641288

2641289

2641293

2641294

2641295

2641296

2641297

2641298

2641300

2641301

2641302

2641303

2641304

2641305

2641309

2641310

2641311

2641312

2641313

2641314

45003_r_at

7879

8082431

A_14_P133140

A_24_P234572

A_33_P3361851

GE62295

GE905794

GO:0000045

GO:0000166

GO:0000421

GO:0003824

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005737

GO:0005739

GO:0005764

GO:0005765

GO:0005768

GO:0005770

GO:0005773

GO:0005794

GO:0005811

GO:0005829

GO:0005886

GO:0006622

GO:0006629

GO:0006886

GO:0006897

GO:0006914

GO:0007174

GO:0008333

GO:0009617

GO:0010008

GO:0015031

GO:0016020

GO:0016042

GO:0016192

GO:0016787

GO:0019003

GO:0019076

GO:0022615

GO:0030163

GO:0030667

GO:0030670

GO:0030672

GO:0030904

GO:0031267

GO:0031410

GO:0031902

GO:0031966

GO:0033162

GO:0034045

GO:0036466

GO:0042147

GO:0043226

GO:0043231

GO:0045022

GO:0045335

GO:0045453

GO:0045732

GO:0046907

GO:0048524

GO:0051650

GO:0061024

GO:0061724

GO:0070062

GO:0072659

GO:0090382

GO:0090383

GO:0090385

GO:0097208

GO:0098772

GO:0098830

GO:0098943

GO:0098978

GO:0099003

GO:0099638

GO:1903542

GO:1903543

GO:1905366

GO:1905394

HMNXSV003026071

Hs.237955.3.S1_3p_a_at

Hs.237955.3.S2_3p_at

Hs2.372904.1.S1_3p_at

ILMN_1716524

PH_hs_0017281

TC03000677.hg

X93499_at

Participates

as a candidate of

RABs [cytosol] (Homo sapiens)

as a member of

RAB5A,RAB7A [cytosol] (Homo sapiens)

Other forms of this molecule

RAB7A [secretory granule membrane]

RAB7A [plasma membrane]

RAB7A [phagocytic vesicle membrane]

RAB7A [lysosomal membrane]

GGC-RAB7A [cytosol]

GGC-RAB7A [lysosomal membrane]

Inferred To

rab7a [cytosol] (Danio rerio)

rab7a [cytosol] (Xenopus tropicalis)

rab-7 [cytosol] (Caenorhabditis elegans)

RAB7A [cytosol] (Bos taurus)

RAB7A [cytosol] (Canis familiaris)

RAB7A [cytosol] (Dictyostelium discoideum)

RAB7A [cytosol] (Drosophila melanogaster)

RAB7A [cytosol] (Gallus gallus)

RAB7A [cytosol] (Mus musculus)

RAB7A [cytosol] (Plasmodium falciparum)

RAB7A [cytosol] (Rattus norvegicus)

RAB7A [cytosol] (Saccharomyces cerevisiae)

RAB7A [cytosol] (Schizosaccharomyces pombe)

RAB7A [cytosol] (Sus scrofa)

Cross References

OpenTargets

ENSG00000075785

ENSEMBL

ENST00000676214, ENST00000265062, ENSP00000501618, ENSP00000265062, ENST00000674589, ENSP00000502000, ENSP00000502088, ENSP00000502486, ENST00000675342, ENST00000675497

HPA

ENSG00000075785-RAB7A

PRO

P51149

Pharos - Targets

P51149

GlyGen

P51149

Orphanet

RAB7A

PDB

1YHN, 3LAW, 1T91, 6IYB, 6WCW, 7F6J

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96NA2 RILP	1	RILP [lysosomal membrane] (R-HSA-2213229)	0.926	11
UniProt:Q9Y4G2 PKHM1			0.803	11
UniProt:P31150 GDI1	1	GDI1 [cytosol] (R-HSA-195106)	0.725	6
UniProt:Q9BXW6 OSBPL1A	1	OSBPL1A [cytosol] (R-HSA-2213214)	0.672	5
UniProt:Q9NVJ2 ARL8B			0.597	7
UniProt:P86791 CCZ1	1	CCZ1 [cytosol] (R-HSA-8877441)	0.59	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	11
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:Q9UNS2 COPS3	2	COPS3 [nucleoplasm] (R-HSA-5697017) COPS3 [cytosol] (R-HSA-416973)	0.556	3
UniProt:Q9GZS3 SKIC8	2	WDR61 [cytosol] (R-HSA-8931534) WDR61 [nucleoplasm] (R-HSA-8866696)	0.556	3
UniProt:Q02535 ID3	1	ID3 [nucleoplasm] (R-HSA-9613379)	0.556	3
UniProt:Q6ZR37 PKHG7			0.556	3
UniProt:Q8WXF7 ATLA1			0.556	3
UniProt:O75348 ATP6V1G1	1	ATP6V1G1 [cytosol] (R-HSA-912578)	0.527	2
UniProt:P61421 ATPV0D1	3	ATP6V0D1 [endosome membrane] (R-HSA-912592) ATP6V0D1 [phagocytic vesicle membrane] (R-HSA-1222571) ATP6V0D1 [lysosomal membrane] (R-HSA-9640177)	0.527	2
UniProt:P0DTD1-PRO_0000449625 REP			0.527	2
UniProt:P61019 RAB2A	3	GGC-RAB2A [cytosol] (R-HSA-8873963) RAB2A [cytosol] (R-HSA-8873716) RAB2A [Golgi membrane] (R-HSA-2422386)	0.527	2
UniProt:P21796 VDAC1	7	p-S65-Ub:VDAC1 [mitochondrial outer membrane] (R-HSA-9834991) K63polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-9834037) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) Ub-VDAC1 [mitochondrial outer membrane] (R-HSA-9834989) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079)	0.527	2
UniProt:P21281 ATP6V1B2	1	ATP6V1B2 [cytosol] (R-HSA-912598)	0.527	2
UniProt:Q5ZU30 SETA			0.525	2
UniProt:Q96JC1 VPS39	1	VPS39 [endosome membrane] (R-HSA-2197806)	0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	6
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2
UniProt:A0A0F6B1Q8 A0A0F6B1Q8			0.462	2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2

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