K63polyUb-K164-PCNA [nucleoplasm]

Stable Identifier
R-HSA-8943000
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Proliferating cell nuclear antigen, PCNA_HUMAN
K63polyUb-K164-PCNA [nucleoplasm] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
18719106 Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks

Roest, HP, Ding, H, Motegi, A, Myung, K, Markowitz, SD, Wu, X, Liaw, HJ, Lee, KY, Moinova, H, Hoeijmakers, JH, Maas, A

Proc. Natl. Acad. Sci. U.S.A. 2008
17108083 Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen

Haracska, L, Hurwitz, J, Blastyák, A, Bermudez, V, Prakash, L, Fatyol, K, Hajdu, I, Unk, I, Szakál, B, Prakash, S

Proc. Natl. Acad. Sci. U.S.A. 2006
17130289 Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination

Motegi, A, Myung, K, Markowitz, SD, Sood, R, Liu, PP, Moinova, H

J. Cell Biol. 2006
External Reference Information
External Reference
Gene Names
PCNA
Chain
chain:1-261
Other Identifiers
11716103_a_at
16916958
1824_s_at
1884_s_at
201202_PM_at
201202_at
3896201
3896202
3896203
3896204
3896206
3896207
3896209
3896211
3896213
3896214
3896215
3896216
4006657
4006658
5111
8064844
A_23_P28886
A_33_P3258612
GE61312
GO:0000122
GO:0000228
GO:0000278
GO:0000307
GO:0000701
GO:0000781
GO:0000785
GO:0001673
GO:0003677
GO:0003682
GO:0003684
GO:0003824
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005652
GO:0005654
GO:0005657
GO:0005694
GO:0005813
GO:0005815
GO:0005856
GO:0006260
GO:0006272
GO:0006275
GO:0006281
GO:0006287
GO:0006298
GO:0006351
GO:0006355
GO:0006974
GO:0006979
GO:0007507
GO:0016604
GO:0016787
GO:0019899
GO:0019985
GO:0022414
GO:0030154
GO:0030331
GO:0030337
GO:0030855
GO:0030894
GO:0030971
GO:0031297
GO:0032077
GO:0032139
GO:0032200
GO:0032355
GO:0032405
GO:0033993
GO:0034644
GO:0035035
GO:0042802
GO:0043226
GO:0043596
GO:0043626
GO:0044849
GO:0044877
GO:0045739
GO:0045740
GO:0046686
GO:0048856
GO:0070062
GO:0070182
GO:0070301
GO:0070557
GO:0071466
GO:0071548
GO:0097421
GO:0098772
GO:0140097
GO:1900264
GO:1902065
GO:1902990
HMNXSV003000505
HMNXSV003026895
ILMN_1685682
ILMN_1694177
ILMN_1706958
J05614_at
M15796_at
PH_hs_0028994
TC20000592.hg
g4505640_3p_at
Participates
Other forms of this molecule
Inferred To
Modified Residues
Name
ubiquitinylated lysine (K63polyUb [nucleoplasm]) at 164
Coordinate
164
Modification
K63polyUb [nucleoplasm]
PsiMod Name
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
ZINC - Metabolites
GeneCards
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
Interactors (56)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P38936 CDKN1A  5 0.977 39
 UniProt:P39748 FEN1  1 0.964 22
 UniProt:P12004 PCNA  5 0.898 11
 UniProt:Q15054 POLD3  1 0.83 7
 IntAct:EBI-4399559 UBIQ      0.811 7
 UniProt:Q15004 PCLAF  2 0.8 7
 UniProt:Q13111 CAF1A      0.734 4
 UniProt:P20585 MSH3  2 0.718 6
 UniProt:P49005 POLD2  1 0.678 3
 UniProt:O95944 NCR2  1 0.672 7
 UniProt:P28340 POLD1  2 0.669 3
 UniProt:A2RU14 TM218      0.666 4
 UniProt:Q9Z111 GA45G      0.664 9
 UniProt:P24941 CDK2  5 0.643 4
 UniProt:P13569 CFTR  17 0.615 14
 UniProt:P42771 CDKN2A  20 0.61 8
 UniProt:Q5FWF4 ZRAB3      0.599 8
 UniProt:P24385 CCND1  4 0.59 2
 UniProt:P24522 GADD45A  1 0.589 3
 UniProt:Q9H063 MAF1  3 0.581 4
 UniProt:P30041 PRDX6  3 0.573 2
 UniProt:P61769 B2M  11 0.573 3
 UniProt:P68104 EEF1A1  7 0.573 2
 UniProt:P00558 PGK1  1 0.573 2
 UniProt:P07355 ANXA2  6 0.573 2
 UniProt:P04075 ALDOA  6 0.571 3
 UniProt:P04406 GAPDH  1 0.571 3
 UniProt:P06733 ENO1  1 0.571 3
 UniProt:Q14527 HLTF  1 0.564 2
 UniProt:P61970 NTF2      0.556 3
 UniProt:Q9NZD8 SPG21      0.556 3
 UniProt:Q96DZ9-2 CMTM5      0.556 3
 UniProt:Q8IWU4 SLC30A8  2 0.556 3
 UniProt:P03129 VE7      0.547 2
 UniProt:A8CG34 POM121C  1 0.547 2
 UniProt:Q8IWL3 HSCB  5 0.547 2
 UniProt:P18669 PGAM1  4 0.544 2
 UniProt:Q9H160 ING2  2 0.544 3
 UniProt:P60174 TPI1  1 0.544 2
 UniProt:P03950 ANG  2 0.537 4
 UniProt:P35249 RFC4  1 0.527 2
 UniProt:P24864 CCNE1  3 0.527 3
 UniProt:P35250 RFC2  1 0.527 2
 UniProt:O96020 CCNE2  3 0.527 3
 UniProt:Q5S007 LRRK2  1 0.527 3
 UniProt:P52701 MSH6  2 0.527 2
 UniProt:P20248 CCNA2  3 0.527 3
 UniProt:P14635 CCNB1  4 0.527 3
 UniProt:Q9HCU8 POLD4  1 0.524 4
 UniProt:B4URF7 B4URF7      0.508 2
 UniProt:Q86TU7 SETD3  1 0.508 3
 UniProt:Q1K9H5 Q1K9H5      0.508 2
 UniProt:Q9UBF6 RNF7  1 0.508 3
 UniProt:Q8TE30 Q8TE30      0.499 6
 UniProt:Q9H211 CDT1  1 0.499 2
 UniProt:P57081 WDR4  1 0.462 3
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