Reactome | ADAR [nucleoplasm]

ADAR [nucleoplasm]

Stable Identifier

R-HSA-53939

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

ADAR1 protein, P136, 136 kDa double-stranded RNA binding protein, Double-stranded RNA-specific adenosine deaminase , DRADA, Double-stranded RNA-specific adenosine deaminase , K88DSRBP, Interferon-inducible protein 4, IFI-4 protein

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External Reference Information

External Reference

UniProt:P55265 ADAR

Gene Names

ADAR, ADAR1, DSRAD, G1P1, IFI4

Chain

chain:1-1226

Reference Genes

BioGPS Gene:103 ADAR

COSMIC (genes):ADAR ADAR

CTD Gene:103 ADAR

dbSNP Gene:103 ADAR

ENSEMBL:ENSG00000160710 ADAR

HGNC:225 ADAR

KEGG:hsa:103 ADAR

Monarch:103 ADAR

NCBI Gene:103 ADAR

OMIM:146920 ADAR

UCSC:P55265 ADAR

Reference Transcript

Participates

as an input of

Formation of ADAR1 homodimer (Homo sapiens)

as a component of

ADAR1 homodimer [nucleoplasm] (Homo sapiens)

as an output of

Expression of IFN-induced genes (Homo sapiens)

Other forms of this molecule

ADAR1 [cytosol]

Inferred To

ADAR1 [nucleoplasm] (Gallus gallus)

ADAR [nucleoplasm] (Bos taurus)

ADAR [nucleoplasm] (Canis familiaris)

ADAR [nucleoplasm] (Mus musculus)

ADAR [nucleoplasm] (Rattus norvegicus)

ADAR [nucleoplasm] (Sus scrofa)

Cross References

OpenTargets

ENSG00000160710

ENSEMBL

ENSP00000506234, ENST00000681056, ENST00000649022, ENST00000649042, ENST00000529168, ENSP00000497210, ENSP00000497555, ENSP00000497790, ENSP00000357459, ENSP00000357456, ENSP00000431794, ENST00000368474, ENST00000368471, ENSP00000496896, ENST00000649749, ENSG00000160710, ENST00000681683, ENST00000649724, ENSP00000498137, ENST00000648231, ENSP00000497932, ENST00000680270, ENSP00000505532, ENSP00000506666, ENST00000648311

HPA

ENSG00000160710-ADAR

GeneCards

ADAR

PRO

P55265

Pharos - Targets

P55265

GlyGen

P55265

Orphanet

ADAR

PDB

7C0I, 5ZUP, 5ZU1, 1XMK, 8GBD, 2ACJ, 3F21, 1QGP, 2MDR, 8GBC, 1QBJ, 3F22, 7ZLQ, 7ZJ1, 5ZUO, 3IRQ, 3F23, 2L54, 2GXB, 3IRR

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03496 NS	2	NS1 [nucleoplasm] (R-FLU-169113) NS1 [cytosol] (R-FLU-169118)	0.655	8
UniProt:Q13148 TADBP			0.556	3
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.527	2
UniProt:P19525 EIF2AK2	5	EIF2AK2 [cytosol] (R-HSA-168699) p-EIF2AK2 [cytosol] (R-HSA-9833834) ISG15-EIF2AK2 [cytosol] (R-HSA-9833968) SUMO-EIF2AK2 [cytosol] (R-HSA-9834829) p-EIF2AK2 [nucleoplasm] (R-HSA-9836332)	0.527	2
UniProt:Q13618 CUL3	3	CUL3 [cytosol] (R-HSA-975979) CUL3 [nucleoplasm] (R-HSA-5635033) G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516)	0.527	2
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.524	3
UniProt:P14340-PRO_0000037965			0.508	2
UniProt:Q99IB8-PRO_0000045599			0.488	3
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	14

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