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HSPA4L [cytosol]
Stable Identifier
R-HSA-5251943
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Heat shock 70 kDa protein 4L, HS74L_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
HSP110s exchange ATP for ADP on HSP70s:ADP (Homo sapiens)
HSP70s:ADP [cytosol] (Homo sapiens)
HSPA4L:ADP [cytosol] (Homo sapiens)
HSPA4L [cytosol] (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA4L:ATP [cytosol] (Homo sapiens)
HSPA4L [cytosol] (Homo sapiens)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Homo sapiens)
HSP70s:ADP [cytosol] (Homo sapiens)
HSPA4L:ADP [cytosol] (Homo sapiens)
HSPA4L [cytosol] (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA4L:ATP [cytosol] (Homo sapiens)
HSPA4L [cytosol] (Homo sapiens)
Hikeshi binds HSP70s:ATP (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA4L:ATP [cytosol] (Homo sapiens)
HSPA4L [cytosol] (Homo sapiens)
Hikeshi:HSP70s:ATP [cytosol] (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA4L:ATP [cytosol] (Homo sapiens)
HSPA4L [cytosol] (Homo sapiens)
NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Homo sapiens)
Hikeshi:HSP70s:ATP [cytosol] (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA4L:ATP [cytosol] (Homo sapiens)
HSPA4L [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95757 HSPA4L
Gene Names
HSPA4L, APG1, OSP94, OSP94
Chain
chain:1-839
Reference Genes
BioGPS Gene:22824 HSPA4L
COSMIC (genes):HSPA4L HSPA4L
CTD Gene:22824 HSPA4L
dbSNP Gene:22824 HSPA4L
ENSEMBL:ENSG00000164070 HSPA4L
HGNC:17041 HSPA4L
KEGG:hsa:22824 HSPA4L
Monarch:22824 HSPA4L
NCBI Gene:22824 HSPA4L
OMIM:619077 HSPA4L
UCSC:O95757 HSPA4L
Reference Transcript
RefSeq:NM_001317382.1 HSPA4L
RefSeq:NM_014278.3 HSPA4L
RefSeq:NM_001317381.1 HSPA4L
RefSeq:NM_001317383.1 HSPA4L
Other Identifiers
11728697_a_at
11728698_at
11750627_a_at
1556194_PM_a_at
1556194_a_at
16970536
205543_PM_at
205543_at
22824
2742936
2742937
2742938
2742942
2742943
2742944
2742946
2742947
2742948
2742949
2742950
2742951
2742952
2742955
2742958
2742961
2742963
2742964
2742965
2742966
2742967
2742968
2742969
2742970
2742971
2742972
2742973
2742974
2742976
2742978
2742980
3040535
3040536
3267562
3506844
3506847
3506848
3780970
40354_at
78874_at
8097335
A_19_P00326917
A_19_P00331034
A_23_P363936
A_32_P95176
GE53659
GE540527
GE892452
GO:0000774
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0006457
GO:0006986
GO:0043226
GO:0044183
GO:0098772
GO:0140657
GO:0140662
HMNXSV003035088
Hs2.330715.1.A1_3p_s_at
ILMN_1732468
PH_hs_0022540
TC04000643.hg
TC04000644.hg
TC04002195.hg
g7656893_3p_at
p26268
Participates
as a component of
HSPA4L:ADP [cytosol] (Homo sapiens)
HSPA4L:ATP [cytosol] (Homo sapiens)
Other forms of this molecule
HSPA4L [nucleoplasm]
Inferred To
hspH [cytosol]
(Dictyostelium discoideum)
SSE1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of HSPA4L [cytosol]
(Saccharomyces cerevisiae)
hsp-110 [cytosol]
(Caenorhabditis elegans)
HSPA4L [cytosol]
(Bos taurus)
HSPA4L [cytosol]
(Canis familiaris)
HSPA4L [cytosol]
(Plasmodium falciparum)
HSPA4L [cytosol]
(Sus scrofa)
pss1 [cytosol]
(Schizosaccharomyces pombe)
SSE2 [cytosol]
(Saccharomyces cerevisiae)
Hspa4l [cytosol]
(Mus musculus)
Cross References
ENSEMBL
ENST00000508776
,
ENSP00000296464
,
ENST00000296464
,
ENSP00000422482
OpenTargets
ENSG00000164070
HPA
ENSG00000164070-HSPA4L
PRO
O95757
Pharos - Targets
O95757
GlyGen
O95757
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.569
4
UniProt:P11021 HSPA5
6
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [extracellular region]
(R-HSA-351322)
0.527
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
11
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